6UP7
 
 | | neurotensin receptor and arrestin2 complex | | Descriptor: | ARG-ARG-PRO-TYR-ILE-LEU, Beta-arrestin-1, Neurotensin receptor type 1, ... | | Authors: | Qu, Q.H, Huang, W, Masureel, M, Janetzko, J, Kobilka, B.K, Skiniotis, G. | | Deposit date: | 2019-10-16 | | Release date: | 2020-02-26 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of the neurotensin receptor 1 in complex with beta-arrestin 1.
Nature, 579, 2020
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4F42
 | | Neurotrophin p75NTR intracellular domain | | Descriptor: | 5-MERCAPTO-2-NITRO-BENZOIC ACID, Tumor necrosis factor receptor superfamily member 16 | | Authors: | Qu, Q, Jiang, T. | | Deposit date: | 2012-05-09 | | Release date: | 2013-05-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Structural insights into the allosteric activation mechanism of p75NTR
To be Published
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4F44
 | | Neurotrophin p75NTR intracellular domain | | Descriptor: | 5-MERCAPTO-2-NITRO-BENZOIC ACID, Tumor necrosis factor receptor superfamily member 16 | | Authors: | Qu, Q, Jiang, T. | | Deposit date: | 2012-05-10 | | Release date: | 2013-05-15 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural insights into the allosteric activation mechanism of p75NTR
To be Published
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8XMA
 | | Cryo-EM structure of human ZnT1 WT, in the presence of zinc, determined in an outward-facing conformation | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, Proton-coupled zinc antiporter SLC30A1, ... | | Authors: | Qu, Q, Long, Y, Zhou, Z. | | Deposit date: | 2023-12-27 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Structural insights into human zinc transporter ZnT1 mediated Zn 2+ efflux.
Embo Rep., 2024
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8XMJ
 | | Cryo-EM structure of human ZnT1 WT, in the presence of zinc, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, Proton-coupled zinc antiporter SLC30A1, ... | | Authors: | Qu, Q, Long, Y, Zhou, Z. | | Deposit date: | 2023-12-27 | | Release date: | 2024-10-30 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4.18 Å) | | Cite: | Structural insights into human zinc transporter ZnT1 mediated Zn 2+ efflux.
Embo Rep., 2024
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8XMF
 | | Cryo-EM structure of human ZnT1 WT at a low PH, in the presence of zinc, determined in an inward-facing conformation. | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, Proton-coupled zinc antiporter SLC30A1, ... | | Authors: | Qu, Q, Long, Y, Zhou, Z. | | Deposit date: | 2023-12-27 | | Release date: | 2024-10-30 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | Structural insights into human zinc transporter ZnT1 mediated Zn 2+ efflux.
Embo Rep., 2024
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8XM6
 | | Cryo-EM structure of human ZnT1 WT, in the absence of zinc, determined in an outward-facing conformation | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, Proton-coupled zinc antiporter SLC30A1, ... | | Authors: | Qu, Q, Long, Y, Zhou, Z. | | Deposit date: | 2023-12-27 | | Release date: | 2024-10-30 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structural insights into human zinc transporter ZnT1 mediated Zn 2+ efflux.
Embo Rep., 2024
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7SL8
 | | CryoEM structure of SGLT1 at 3.4 A resolution | | Descriptor: | CHOLESTEROL, Sodium/glucose cotransporter 1, nanobody Nb1 | | Authors: | Qu, Q, Han, L, Panova, O, Feng, L, Skiniotis, G. | | Deposit date: | 2021-10-23 | | Release date: | 2021-12-15 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure and mechanism of the SGLT family of glucose transporters.
Nature, 601, 2022
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7SL9
 | | CryoEM structure of SMCT1 | | Descriptor: | Sodium-coupled monocarboxylate transporter 1, butanoic acid, nanobody Nb2 | | Authors: | Qu, Q, Han, L, Panova, O, Feng, L, Skiniotis, G. | | Deposit date: | 2021-10-23 | | Release date: | 2021-12-15 | | Last modified: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure and mechanism of the SGLT family of glucose transporters.
Nature, 601, 2022
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7SLA
 | | CryoEM structure of SGLT1 at 3.15 Angstrom resolution | | Descriptor: | CHOLESTEROL HEMISUCCINATE, Sodium/glucose cotransporter 1, nanobody Nb1 | | Authors: | Qu, Q, Han, L, Panova, O, Feng, L, Skiniotis, G. | | Deposit date: | 2021-10-23 | | Release date: | 2021-12-15 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Structure and mechanism of the SGLT family of glucose transporters.
Nature, 601, 2022
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8WLL
 | | Cryo-EM structure of human VMAT2 Y422C, in the presence of reserpine, determined in an inward-facing conformation | | Descriptor: | Synaptic vesicular amine transporter, reserpine | | Authors: | Qu, Q, Wang, Y, Zhou, Z. | | Deposit date: | 2023-09-30 | | Release date: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.74 Å) | | Cite: | Cryo-EM structure of human VMAT2 Y422C, in the presence of reserpine, determined in an inward-facing conformation
To Be Published
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8WLJ
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8WLK
 | | Cryo-EM structure of human VMAT2 in presence of Tetrabenazine, determined in an outward-facing conformation | | Descriptor: | (3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one, Synaptic vesicular amine transporter | | Authors: | Qu, Q, Wang, Y, Zhou, Z. | | Deposit date: | 2023-09-30 | | Release date: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Cryo-EM structure of human apo VMAT2 in an outward-facing conformation
To Be Published
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8WLM
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8YF0
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8YF1
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6KZF
 | | Racemic X-ray Structure of Calcicludine | | Descriptor: | D-calcicludine, Kunitz-type serine protease inhibitor homolog calcicludine | | Authors: | Qu, Q, Gao, S, Liu, L. | | Deposit date: | 2019-09-24 | | Release date: | 2019-11-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy
Angew.Chem.Int.Ed.Engl., 59, 2020
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7RKN
 | | Structure of CX3CL1-US28-Gi-scFv16 in OC-state | | Descriptor: | Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ... | | Authors: | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | | Deposit date: | 2021-07-22 | | Release date: | 2022-01-26 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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7RKF
 | | Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ... | | Authors: | Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C. | | Deposit date: | 2021-07-22 | | Release date: | 2022-01-26 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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7RKM
 | | Structure of CX3CL1-US28-Gi-scFv16 in C-state | | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ... | | Authors: | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | | Deposit date: | 2021-07-22 | | Release date: | 2022-01-26 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
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8IMX
 | | Cryo-EM structure of GPI-T with a chimeric GPI-anchored protein | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Xu, Y, Li, T, Qu, Q, Li, D. | | Deposit date: | 2023-03-07 | | Release date: | 2023-08-16 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis.
Nat Commun, 14, 2023
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8IMY
 | | Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Li, T, Xu, Y, Qu, Q, Li, D. | | Deposit date: | 2023-03-07 | | Release date: | 2023-08-16 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis.
Nat Commun, 14, 2023
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7JHJ
 | | Structure of the Epstein-Barr virus GPCR BILF1 in complex with human Gi | | Descriptor: | Antibody fragment scFv16, BILF1, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Tsutsumi, N, Qu, Q.H, Skiniotis, G, Garcia, K.C. | | Deposit date: | 2020-07-20 | | Release date: | 2021-07-07 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1.
Immunity, 54, 2021
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6BX3
 | | Structure of histone H3k4 methyltransferase | | Descriptor: | COMPASS component BRE2, COMPASS component SDC1, COMPASS component SPP1, ... | | Authors: | Skiniotis, G, Qu, Q.H. | | Deposit date: | 2017-12-16 | | Release date: | 2018-09-05 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
Cell, 174, 2018
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3QD7
 | | Crystal structure of YdaL, a stand-alone small MutS-related protein from Escherichia coli | | Descriptor: | Uncharacterized protein ydaL | | Authors: | Gui, W.J, Qu, Q.H, Chen, Y.Y, Wang, M, Zhang, X.E, Bi, L.J, Jiang, T. | | Deposit date: | 2011-01-18 | | Release date: | 2011-06-22 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of YdaL, a stand-alone small MutS-related protein from Escherichia coli.
J.Struct.Biol., 174, 2011
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