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8WLK

Cryo-EM structure of human VMAT2 in presence of Tetrabenazine, determined in an outward-facing conformation

Summary for 8WLK
Entry DOI10.2210/pdb8wlk/pdb
EMDB information37622
DescriptorSynaptic vesicular amine transporter, (3S,5R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one (2 entities in total)
Functional Keywordshuman vmat2, tetrabenazine, outward-facing conformation, transport protein
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight54140.61
Authors
Qu, Q.,Wang, Y.,Zhou, Z. (deposition date: 2023-09-30, release date: 2024-06-12)
Primary citationQu, Q.,Wang, Y.,Zhou, Z.
Cryo-EM structure of human apo VMAT2 in an outward-facing conformation
To Be Published,
Experimental method
Structure validation

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