3CTQ
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![BU of 3ctq by Molmil](/molmil-images/mine/3ctq) | Structure of MAP kinase p38 in complex with a 1-o-tolyl-1,2,3-triazole-4-carboxamide | 分子名称: | Mitogen-activated protein kinase 14, N-benzyl-1-[5-({5-tert-butyl-2-methoxy-3-[(methylsulfonyl)amino]phenyl}carbamoyl)-2-methylphenyl]-1H-1,2,3-triazole-4-carboxamide | 著者 | Qian, K. | 登録日 | 2008-04-14 | 公開日 | 2008-05-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-based design and subsequent optimization of 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) inhibitors of p38 MAP kinase. Bioorg.Med.Chem.Lett., 18, 2008
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1XQZ
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![BU of 1xqz by Molmil](/molmil-images/mine/1xqz) | Crystal Structure of hPim-1 kinase at 2.1 A resolution | 分子名称: | Proto-oncogene serine/threonine-protein kinase Pim-1 | 著者 | Qian, K.C, Wang, L, Hickey, E.R, Studts, J, Barringer, K, Peng, C, Kronkaitis, A, Li, J, White, A, Mische, S, Farmer, B. | 登録日 | 2004-10-13 | 公開日 | 2004-11-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase. J.Biol.Chem., 280, 2005
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3S0N
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![BU of 3s0n by Molmil](/molmil-images/mine/3s0n) | Crystal Structure of Human Chymase with Benzimidazolone Inhibitor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-{3-[(4-methyl-1-benzothiophen-3-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}butanoic acid, Chymase, ... | 著者 | Qian, K.C, Farrow, N.A, Padyana, A.K. | 登録日 | 2011-05-13 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P(1)) region. Bioorg.Med.Chem.Lett., 21, 2011
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7VI6
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![BU of 7vi6 by Molmil](/molmil-images/mine/7vi6) | Crystal structure of GH3 beta-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila | 分子名称: | Beta-N-acetylhexosaminidase, CHLORIDE ION, MAGNESIUM ION | 著者 | Qian, K, Yang, W, Chen, X, Wang, Y, Zhang, M, Wang, M. | 登録日 | 2021-09-26 | 公開日 | 2021-12-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Functional and structural characterization of a GH3 beta-N-acetylhexosaminidase from Akkermansia muciniphila involved in mucin degradation Biochem.Biophys.Res.Commun., 589, 2022
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7VI7
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![BU of 7vi7 by Molmil](/molmil-images/mine/7vi7) | Crystal structure of GH3 beta-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila in complex with GlcNAc | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | 著者 | Qian, K, Yang, W, Chen, X, Wang, Y, Zhang, M, Wang, M. | 登録日 | 2021-09-26 | 公開日 | 2021-12-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Functional and structural characterization of a GH3 beta-N-acetylhexosaminidase from Akkermansia muciniphila involved in mucin degradation Biochem.Biophys.Res.Commun., 589, 2022
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1XR1
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![BU of 1xr1 by Molmil](/molmil-images/mine/1xr1) | Crystal structure of hPim-1 kinase in complex with AMP-PNP at 2.1 A Resolution | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proto-oncogene serine/threonine-protein kinase Pim-1 | 著者 | Qian, K.C, Wang, L, Hickey, E.R, Studts, J, Barringer, K, Peng, C, Kronkaitis, A, Li, J, White, A, Mische, S, Farmer, B. | 登録日 | 2004-10-13 | 公開日 | 2004-11-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase. J.Biol.Chem., 280, 2005
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2PUU
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![BU of 2puu by Molmil](/molmil-images/mine/2puu) | |
3F2A
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![BU of 3f2a by Molmil](/molmil-images/mine/3f2a) | Crystal structure of human Pim-1 in complex with DAPPA | 分子名称: | (2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid, MAGNESIUM ION, Proto-oncogene serine/threonine-protein kinase Pim-1 | 著者 | Qian, K. | 登録日 | 2008-10-29 | 公開日 | 2009-03-10 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. J.Med.Chem., 52, 2009
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3GI3
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![BU of 3gi3 by Molmil](/molmil-images/mine/3gi3) | |
6JVX
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![BU of 6jvx by Molmil](/molmil-images/mine/6jvx) | Crystal structure of RBM38 in complex with RNA | 分子名称: | RNA (5'-R(*UP*GP*UP*GP*UP*GP*UP*GP*UP*GP*UP*G)-3'), RNA-binding protein 38, SULFATE ION | 著者 | Qian, K, Li, M, Wang, J, Zhang, M, Wang, M. | 登録日 | 2019-04-17 | 公開日 | 2020-01-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | 主引用文献 | Structural basis for mRNA recognition by human RBM38. Biochem.J., 477, 2020
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6JVY
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![BU of 6jvy by Molmil](/molmil-images/mine/6jvy) | Crystal structure of RBM38 in complex with single-stranded DNA | 分子名称: | DNA (5'-D(*TP*GP*TP*GP*TP*GP*TP*GP*TP*GP*TP*G)-3'), RNA-binding protein 38, SULFATE ION | 著者 | Qian, K, Li, M, Wang, J, Zhang, M, Wang, M. | 登録日 | 2019-04-17 | 公開日 | 2020-01-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | 主引用文献 | Structural basis for mRNA recognition by human RBM38. Biochem.J., 477, 2020
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4G1N
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![BU of 4g1n by Molmil](/molmil-images/mine/4g1n) | PKM2 in complex with an activator | 分子名称: | MAGNESIUM ION, N-(4-{[4-(pyrazin-2-yl)piperazin-1-yl]carbonyl}phenyl)quinoline-8-sulfonamide, OXALATE ION, ... | 著者 | Kung, C, Hixon, J, Dang, L, DeLaBarre, B, Qian, K.C. | 登録日 | 2012-07-10 | 公開日 | 2012-10-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy. Chem.Biol., 19, 2012
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6A4I
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![BU of 6a4i by Molmil](/molmil-images/mine/6a4i) | Crystal Structure of human TDO inhibitor complex | 分子名称: | 1-(6-chloro-1H-indazol-4-yl)cyclohexan-1-ol, CITRIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Fu, G, Wang, J, Luo, G, Wu, G, Qian, K. | 登録日 | 2018-06-20 | 公開日 | 2018-07-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Crystal Structure of human TDO inhibitor complex To Be Published
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4JA8
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![BU of 4ja8 by Molmil](/molmil-images/mine/4ja8) | Complex of Mitochondrial Isocitrate Dehydrogenase R140Q Mutant with AGI-6780 Inhibitor | 分子名称: | 1-[5-(cyclopropylsulfamoyl)-2-thiophen-3-yl-phenyl]-3-[3-(trifluoromethyl)phenyl]urea, CALCIUM ION, GLYCEROL, ... | 著者 | Wei, W, Chen, L, Wu, M, Jiang, F, Travins, J, Qian, K, DeLaBarre, B. | 登録日 | 2013-02-18 | 公開日 | 2013-04-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science, 340, 2013
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