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3S0N

Crystal Structure of Human Chymase with Benzimidazolone Inhibitor

Summary for 3S0N
Entry DOI10.2210/pdb3s0n/pdb
DescriptorChymase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
Functional Keywordsserine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight25880.14
Authors
Qian, K.C.,Farrow, N.A.,Padyana, A.K. (deposition date: 2011-05-13, release date: 2011-07-20, Last modification date: 2023-09-13)
Primary citationLo, H.Y.,Nemoto, P.A.,Kim, J.M.,Hao, M.H.,Qian, K.C.,Farrow, N.A.,Albaugh, D.R.,Fowler, D.M.,Schneiderman, R.D.,Michael August, E.,Martin, L.,Hill-Drzewi, M.,Pullen, S.S.,Takahashi, H.,De Lombaert, S.
Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P(1)) region.
Bioorg.Med.Chem.Lett., 21:4533-4539, 2011
Cited by
PubMed: 21733690
DOI: 10.1016/j.bmcl.2011.05.126
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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