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PDB: 55 件
1FJ8
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THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN
分子名称: (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I
著者Price, A.C, Choi, K, Heath, R.J, Li, Z, White, S.W, Rock, C.O.
登録日2000-08-07
公開日2000-08-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.
J.Biol.Chem., 276, 2001
1FJ4
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THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH THIOLACTOMYCIN, IMPLICATIONS FOR DRUG DESIGN
分子名称: BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I, THIOLACTOMYCIN
著者Price, A.C, Choi, K, Heath, R.J, Li, Z, White, S.W, Rock, C.O.
登録日2000-08-07
公開日2000-08-23
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.
J.Biol.Chem., 276, 2001
1OXH
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The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus Pneumoniae, Triclinic form
分子名称: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
著者Price, A.C, Rock, C.O, White, S.W.
登録日2003-04-02
公開日2003-04-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
4LQW
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Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin
分子名称: Capsid protein p24, E3 SUMO-protein ligase RanBP2
著者Price, A.J, James, L.C.
登録日2013-07-19
公開日2013-08-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358.
Retrovirology, 10, 2013
2X82
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Evolutionary basis of HIV restriction by the antiretroviral TRIMCyp
分子名称: CAPSID PROTEIN P24
著者Price, A.J, James, L.C.
登録日2010-03-05
公開日2010-09-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Conformational Adaptation of Asian Macaque Trimcyp Directs Lineage Specific Antiviral Activity.
Plos Pathog., 6, 2010
2X83
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Evolutionary basis of HIV restriction by the antiretroviral TRIMCyp
分子名称: HIV-1 CAPSID, TRIM5/CypA fusion protein
著者Price, A.J, James, L.C.
登録日2010-03-05
公開日2010-09-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.
Plos Pathog., 6, 2010
2WLV
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BU of 2wlv by Molmil
Structure of the N-terminal capsid domain of HIV-2
分子名称: GAG POLYPROTEIN
著者Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C.
登録日2009-06-26
公開日2009-09-22
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp
Nat.Struct.Mol.Biol., 16, 2009
2WLW
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Structure of the N-terminal capsid domain of HIV-2
分子名称: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
著者Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C.
登録日2009-06-26
公開日2009-09-22
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp
Nat.Struct.Mol.Biol., 16, 2009
4IPZ
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SmBz bound to Cyclophilin A
分子名称: CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase A, cyclosporine SmBz-CsA
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2013-01-10
公開日2013-11-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献HIV-1 evades innate immune recognition through specific cofactor recruitment.
Nature, 503, 2013
4B4N
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CPSF6 defines a conserved capsid interface that modulates HIV-1 replication
分子名称: CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6, GAG PROTEIN
著者Price, A.J, James, L.C.
登録日2012-07-31
公開日2012-09-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.813 Å)
主引用文献Cpsf6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication.
Plos Pathog., 8, 2012
4XRO
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Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I)
分子名称: Capsid protein p24
著者Price, A.J, James, L.C.
登録日2015-01-21
公開日2015-07-15
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
J.Virol., 89, 2015
1OX0
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The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae
分子名称: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION
著者Price, A.C, Rock, C.O, White, S.W.
登録日2003-03-31
公開日2003-04-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
J.Bacteriol., 185, 2003
4XRQ
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Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) in complex with PF-3450074
分子名称: Capsid protein p24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE
著者Price, A.J, James, L.C.
登録日2015-01-21
公開日2015-07-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
J.Virol., 89, 2015
1I01
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BU of 1i01 by Molmil
CRYSTAL STRUCTURE OF BETA-KETOACYL [ACYL CARRIER PROTEIN] REDUCTASE FROM E. COLI.
分子名称: BETA-KETOACYL [ACP] REDUCTASE
著者Price, A.C, Rock, C.O, White, S.W.
登録日2001-01-27
公開日2001-02-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis.
Biochemistry, 40, 2001
1Q7C
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BU of 1q7c by Molmil
The structure of betaketoacyl-[ACP] reductase Y151F mutant in complex with NADPH fragment
分子名称: 3-oxoacyl-[acyl-carrier protein] reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Price, A.C, Zhang, Y.-M, Rock, C.O, White, S.M.
登録日2003-08-17
公開日2004-02-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Cofactor-Induced Conformational Rearrangements Establish a Catalytically Competent Active Site and a Proton Relay Conduit in FabG
Structure, 12, 2004
5HGL
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Hexameric HIV-1 CA, open conformation
分子名称: CHLORIDE ION, Capsid protein P24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2016-01-08
公開日2016-08-10
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.
Nature, 536, 2016
1Q7B
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The structure of betaketoacyl-[ACP] reductase from E. coli in complex with NADP+
分子名称: 3-oxoacyl-[acyl-carrier protein] reductase, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Price, A.C, Zhang, Y.-M, Rock, C.O, White, S.M.
登録日2003-08-17
公開日2004-02-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Cofactor-Induced Conformational Rearrangements Establish a Catalytically Competent Active Site and a Proton Relay Conduit in FabG
Structure, 12, 2004
4U0F
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Hexameric HIV-1 CA in Complex with BI-2
分子名称: (4S)-4-(4-hydroxyphenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one, 1,2-ETHANEDIOL, Capsid protein p24
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0D
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Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form
分子名称: CHLORIDE ION, Gag polyprotein, Nuclear pore complex protein Nup153
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0C
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Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form
分子名称: Capsid protein p24, Nuclear pore complex protein Nup153
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0B
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Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form
分子名称: Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0A
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Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form
分子名称: CHLORIDE ION, Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0E
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Hexameric HIV-1 CA in complex with PF3450074
分子名称: CHLORIDE ION, Capsid protein p24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.043 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
3GLK
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The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2)
分子名称: Acetyl-CoA carboxylase 2
著者Price, A, Kulathila, R.
登録日2009-03-12
公開日2009-03-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase.
Bioorg.Med.Chem.Lett., 19, 2009
3GID
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The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2) in complex with Soraphen A
分子名称: Acetyl-CoA carboxylase 2, SORAPHEN A
著者Price, A, Kulathila, R.
登録日2009-03-05
公開日2009-03-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase.
Bioorg.Med.Chem.Lett., 19, 2009

 

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