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PDB: 14 件
1DMK
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BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 4-AMINO-6-PHENYL-TETRAHYDROPTERIDINE
分子名称: 2,4-DIAMINO-6-PHENYL-5,6,7,8,-TETRAHYDROPTERIDINE, ACETATE ION, CACODYLATE ION, ...
著者Kotsonis, P, Frohlich, L.G, Raman, C.S, Li, H, Berg, M, Gerwig, R, Groehn, V, Kang, Y, Al-Masoudi, N, Taghavi-Moghadam, S, Mohr, D, Munch, U, Schnabel, J, Martasek, P, Masters, B.S, Strobel, H, Poulos, T, Matter, H, Pfleiderer, W, Schmidt, H.H.
登録日1999-12-14
公開日2000-12-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin
J.Biol.Chem., 276, 2001
1DMJ
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BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 5,6-CYCLIC-TETRAHYDROPTERIDINE
分子名称: 7-AMINO-3,3A,4,5-TETRAHYDRO-8H-2-OXA-5,6,8,9B-TETRAAZA-CYCLOPENTA[A]NAPHTHALENE-1,9-DIONE, ACETATE ION, CACODYLATE ION, ...
著者Kotsonis, P, Frohlich, L.G, Raman, C.S, Li, H, Berg, M, Gerwig, R, Groehn, V, Kang, Y, Al-Masoudi, N, Taghavi-Moghadam, S, Mohr, D, Munch, U, Schnabel, J, Martasek, P, Masters, B.S, Strobel, H, Poulos, T, Matter, H, Pfleiderer, W, Schmidt, H.H.
登録日1999-12-14
公開日2000-12-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin
J.Biol.Chem., 276, 2001
5TE8
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BU of 5te8 by Molmil
Crystal structure of the midazolam-bound human CYP3A4
分子名称: 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
著者Sevrioukova, I, Poulos, T.
登録日2016-09-20
公開日2016-12-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5A1P
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Crystal structure of cytochrome P450 3A4 bound to progesterone and citrate
分子名称: CITRIC ACID, CYTOCHROME P450 3A4, PROGESTERONE, ...
著者Sevrioukova, I, Poulos, T.
登録日2015-05-04
公開日2015-06-24
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Anion-Dependent Stimulation of Cyp3A4 Monooxygenase.
Biochemistry, 54, 2015
4D78
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Cytochrome P450 3A4 bound to an inhibitor
分子名称: CYTOCHROME P450 3A4, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Sevrioukova, I, Poulos, T.
登録日2014-11-21
公開日2015-09-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-Based Inhibitor Design for Evaluation of a Cyp3A4 Pharmacophore Model.
J.Med.Chem., 59, 2016
4C9P
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Structure of camphor bound T260A mutant of CYP101D1
分子名称: CAMPHOR, CYTOCHROME P450, GLYCEROL, ...
著者Batabyal, D, L Poulos, T.
登録日2013-10-02
公開日2013-12-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.799 Å)
主引用文献Crystal Structures and Functional Characterization of Wild Type and Active Sites Mutants of Cyp101D1.
Biochemistry, 52, 2013
4C9L
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Structure of Cyanide and Camphor bound wild type CYP101D1
分子名称: CAMPHOR, CYANIDE ION, CYTOCHROME P450, ...
著者Batabyal, D, L Poulos, T.
登録日2013-10-02
公開日2013-12-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Crystal Structures and Functional Characterization of Wild Type and Active Sites Mutants of Cyp101D1.
Biochemistry, 52, 2013
4C9M
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Structure of substrate free, glycerol bound wild type CYP101D1
分子名称: CYTOCHROME P450, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE
著者Batabyal, D, L Poulos, T.
登録日2013-10-02
公開日2013-12-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Crystal Structures and Functional Characterization of Wild Type and Active Sites Mutants of Cyp101D1.
Biochemistry, 52, 2013
4C9K
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Structure of Camphor and Hydroxycamphor bound wild type CYP101D1
分子名称: 5-EXO-HYDROXYCAMPHOR, CAMPHOR, CYTOCHROME P450, ...
著者Batabyal, D, L Poulos, T.
登録日2013-10-02
公開日2013-12-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Crystal Structures and Functional Characterization of Wild-Type Cyp101D1 and its Active Site Mutants.
Biochemistry, 52, 2013
4C9O
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Structure of Cyanide and Camphor bound D259N mutant of CYP101D1
分子名称: CAMPHOR, CYANIDE ION, CYTOCHROME P450, ...
著者Batabyal, D, L Poulos, T.
登録日2013-10-02
公開日2013-12-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.977 Å)
主引用文献Crystal Structures and Functional Characterization of Wild-Type Cyp101D1 and its Active Site Mutants.
Biochemistry, 52, 2013
4C9N
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Structure of camphor and hydroxycamphor bound D259N mutant of CYP101D1
分子名称: 5-EXO-HYDROXYCAMPHOR, CAMPHOR, CYTOCHROME P450, ...
著者Batabyal, D, L Poulos, T.
登録日2013-10-02
公開日2013-12-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structures and Functional Characterization of Wild Type and Active Sites Mutants of Cyp101D1.
Biochemistry, 52, 2013
4D6Z
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Cytochrome P450 3A4 bound to imidazole and an inhibitor
分子名称: CYTOCHROME P450 3A4, GLYCEROL, IMIDAZOLE, ...
著者Sevrioukova, I, Poulos, T.
登録日2014-11-19
公開日2015-09-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structure-Based Inhibitor Design for Evaluation of a Cyp3A4 Pharmacophore Model.
J.Med.Chem., 59, 2016
4D7D
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BU of 4d7d by Molmil
Cytochrome P450 3A4 bound to an inhibitor
分子名称: CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-(1H-indol-3-yl)-3-({3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl}sulfanyl)propan-2-yl]carbamate
著者Sevrioukova, I, Poulos, T.
登録日2014-11-22
公開日2015-09-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Structure-Based Inhibitor Design for Evaluation of a Cyp3A4 Pharmacophore Model.
J.Med.Chem., 59, 2016
4D75
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Cytochrome P450 3A4 bound to an inhibitor
分子名称: CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl {6-oxo-6-[(pyridin-3-ylmethyl)amino]hexyl}carbamate
著者Sevrioukova, I, Poulos, T.
登録日2014-11-19
公開日2015-09-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure-Based Inhibitor Design for Evaluation of a Cyp3A4 Pharmacophore Model.
J.Med.Chem., 59, 2016

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件を2024-11-13に公開中

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