4D6Z

Cytochrome P450 3A4 bound to imidazole and an inhibitor

Summary for 4D6Z

• Entry DOI: 10.2210/pdb4d6z/pdb
• Related: 4D75
• Descriptor: CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl {6-oxo-6-[(pyridin-3-ylmethyl)amino]hexyl}carbamate, ... (6 entities in total)
• Functional Keywords: oxidoreductase, monooxygenase, cytochrome p450, human cyp3a4, imidazole, inhibitory complex
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Endoplasmic reticulum membrane; Single-pass membrane protein: P08684
• Total number of polymer chains: 1
• Total formula weight: 57017.04

Authors

Sevrioukova, I.,Poulos, T. (deposition date: 2014-11-19, release date: 2015-09-23, Last modification date: 2023-12-20)

• Primary citation: Kaur, P.,Chamberlin, R.,Poulos, T.L.,Sevrioukova, I.F.; Structure-Based Inhibitor Design for Evaluation of a Cyp3A4 Pharmacophore Model.; J.Med.Chem., 59:4210-, 2016; PubMed: 26371436; DOI: 10.1021/ACS.JMEDCHEM.5B01146

Experimental method

X-RAY DIFFRACTION (1.93 Å)