4D6Z
Cytochrome P450 3A4 bound to imidazole and an inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | CYTOCHROME P450 3A4 | polymer | 487 | 55641.7 | 1 | UniProt (P08684) Pfam (PF00067) In PDB | HOMO SAPIENS (HUMAN) | 1,8-CINEOLE 2-EXO-MONOOXYGENASE, ALBENDAZOLE MONOOXYGENASE, ALBENDAZOLE SULFOXIDASE, CYPIIIA3, CYPIIIA4, CYTOCHROME P450 3A3, CYTOCHROME P450 HLP, CYTOCHROME P450 NF-25, CYTOCHROME P450-PCN1, NIFEDIPINE OXIDASE, QUININE 3-MONOOXYGENASE, TAUROCHENODEOXYCHOLATE 6-ALPHA-HYDROXYLASE |
2 | A | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
3 | A | tert-butyl {6-oxo-6-[(pyridin-3-ylmethyl)amino]hexyl}carbamate | non-polymer | 321.4 | 1 | Chemie (PK9) | |||
4 | A | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
6 | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A: 23 - 503 (UniProt: P08684)
PDB | External Database | Details |
---|---|---|
Met 21 | - | expression tag |
Ala 22 | - | expression tag |
His 504 | - | expression tag |
His 505 | - | expression tag |
His 506 | - | expression tag |
His 507 | - | expression tag |
Ala 282 | Lys 282 | engineered mutation |
Ala 285 | Glu 285 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 55641.7 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1375.4 | |
All* | Total formula weight | 57017.0 |