4D7D

Cytochrome P450 3A4 bound to an inhibitor

Summary for 4D7D

Entry DOI	10.2210/pdb4d7d/pdb
Related	4D6Z 4D75 4D78
Descriptor	CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-(1H-indol-3-yl)-3-({3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl}sulfanyl)propan-2-yl]carbamate, ... (4 entities in total)
Functional Keywords	oxidoreductase, monooxygenase, human cyp3a4, inhibitory complex
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	56842.91
Authors	Sevrioukova, I.,Poulos, T. (deposition date: 2014-11-22, release date: 2015-09-23, Last modification date: 2023-12-20)
Primary citation	Kaur, P.,Chamberlin, R.,Poulos, T.L.,Sevrioukova, I.F. Structure-Based Inhibitor Design for Evaluation of a Cyp3A4 Pharmacophore Model. J.Med.Chem., 59:4210-, 2016 Cited by PubMed: 26371436 DOI: 10.1021/ACS.JMEDCHEM.5B01146 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.76 Å)

Structure validation