3EMY
 
 | | Crystal structure of Trichoderma reesei aspartic proteinase complexed with pepstatin A | | Descriptor: | Pepstatin, Trichoderma reesei Aspartic protease | | Authors: | Nascimento, A.S, Krauchenco, S, Golubev, A.M, Gustchina, A, Wlodawer, A, Polikarpov, I. | | Deposit date: | 2008-09-25 | | Release date: | 2008-10-07 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Statistical coupling analysis of aspartic proteinases based on crystal
structures of the Trichoderma reesei enzyme and its complex with pepstatin A.
J.Mol.Biol., 382, 2008
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3EXD
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3GWS
 | | Crystal Structure of T3-Bound Thyroid Hormone Receptor | | Descriptor: | 3,5,3'TRIIODOTHYRONINE, Thyroid hormone receptor beta | | Authors: | Nascimento, A.S, Dias, S.M.G, Nunes, F.M, Aparicio, R, Polikarpov, I, Baxter, J.D, Webb, P. | | Deposit date: | 2009-04-01 | | Release date: | 2009-04-28 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function
J.Mol.Biol., 360, 2006
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3ILN
 | | X-ray structure of the laminarinase from Rhodothermus marinus | | Descriptor: | CALCIUM ION, GLYCEROL, Laminarinase | | Authors: | Bleicher, L, Golubev, A, Rojas, A.L, Nascimento, A.S, Polikarpov, I. | | Deposit date: | 2009-08-07 | | Release date: | 2010-08-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Molecular basis of the thermostability and thermophilicity of laminarinases: X-ray structure of the hyperthermostable laminarinase from Rhodothermus marinus and molecular dynamics simulations.
J.Phys.Chem.B, 115, 2011
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3I36
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3HZF
 | | Structure of TR-alfa bound to selective thyromimetic GC-1 in C2 space group | | Descriptor: | Thyroid hormone receptor, alpha isoform 1 variant, {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid | | Authors: | Aparicio, R, Bleicher, L, Polikarpov, I. | | Deposit date: | 2009-06-23 | | Release date: | 2009-07-21 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.
Bmc Struct.Biol., 8, 2008
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3HDL
 | | Crystal Structure of Highly Glycosylated Peroxidase from Royal Palm Tree | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Watanabe, L, Moura, P.R, Bleicher, L, Nascimento, A.S, Zamorano, L.S, Calvete, J.J, Bursakov, S, Roig, M.G, Shnyrov, V.L, Polikarpov, I. | | Deposit date: | 2009-05-07 | | Release date: | 2009-11-24 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure and statistical coupling analysis of highly glycosylated peroxidase from royal palm tree (Roystonea regia).
J.Struct.Biol., 169, 2010
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3KGU
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3KGT
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3KGS
 | | V30M mutant human transthyretin (TTR) (apoV30M) pH 7.5 | | Descriptor: | Transthyretin | | Authors: | Trivella, D.B, Polikarpov, I. | | Deposit date: | 2009-10-29 | | Release date: | 2010-03-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding.
J.Struct.Biol., 170, 2010
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4DEU
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4DER
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4DEW
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4EMA
 | | Human peroxisome proliferator-activated receptor gamma in complex with rosiglitazone | | Descriptor: | 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), Peroxisome proliferator-activated receptor gamma | | Authors: | Liberato, M.V, Nascimento, A.S, Polikarpov, I. | | Deposit date: | 2012-04-11 | | Release date: | 2013-03-06 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.545 Å) | | Cite: | Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists
Plos One, 7, 2012
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4CI4
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4DET
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4EM9
 | | Human PPAR gamma in complex with nonanoic acids | | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma, ... | | Authors: | Liberato, M.V, Nascimento, A.S, Polikarpov, I. | | Deposit date: | 2012-04-11 | | Release date: | 2013-03-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists
Plos One, 7, 2012
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4CI5
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4CVU
 | | Structure of Fungal beta-mannosidase from Glycoside Hydrolase Family 2 of Trichoderma harzianum | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-MANNOSIDASE, CADMIUM ION, ... | | Authors: | Muniz, J.R.C, Aparicio, R, Santos, J.C, Nascimento, A.S, Golubev, A.M, Polikarpov, I. | | Deposit date: | 2014-03-31 | | Release date: | 2014-07-09 | | Last modified: | 2023-07-05 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Insights into the structure and function of fungal beta-mannosidases from glycoside hydrolase family 2 based on multiple crystal structures of the Trichoderma harzianum enzyme.
FEBS J., 281, 2014
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4DES
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4BCR
 | | Structure of PPARalpha in complex with WY14643 | | Descriptor: | 1,2-ETHANEDIOL, 2-({4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]PYRIMIDIN-2-YL}SULFANYL)ACETIC ACID, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA | | Authors: | Bernardes, A, Muniz, J.R.C, Polikarpov, I. | | Deposit date: | 2012-10-02 | | Release date: | 2013-05-29 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.497 Å) | | Cite: | Molecular Mechanism of Peroxisome Proliferator-Activated Receptor Alpha Activation by Wy14643: A New Mode of Ligand Recognition and Receptor Stabilization
J.Mol.Biol., 425, 2013
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1QLL
 | | Piratoxin-II (Prtx-II) - a K49 PLA2 from Bothrops pirajai | | Descriptor: | N-TRIDECANOIC ACID, PHOSPHOLIPASE A2 | | Authors: | Lee, W.-H, Polikarpov, I. | | Deposit date: | 1999-09-01 | | Release date: | 2000-09-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Structural Basis for Low Catalytic Activity in Lys49 Phospholipases A2-A Hypothesis: The Crystal Structure of Piratoxin II Complexed to Fatty Acid
Biochemistry, 40, 2001
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7K1R
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7KN8
 | | Crystal structure of the GH74 xyloglucanase from Xanthomonas campestris (Xcc1752) | | Descriptor: | 1,2-ETHANEDIOL, Cellulase, IODIDE ION, ... | | Authors: | Araujo, E.A, Vieira, P.S, Murakami, M.T, Polikarpov, I. | | Deposit date: | 2020-11-04 | | Release date: | 2021-05-26 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Xyloglucan processing machinery in Xanthomonas pathogens and its role in the transcriptional activation of virulence factors
Nature Communications, 12, 2021
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7L1W
 | | Unlocking the structural features for the exo-xylobiosidase activity of an unusual GH11 member identified in a compost-derived consortium | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Exo-B-1,4-beta-xylanase | | Authors: | Kadowaki, M.A.S, Polikarpov, I, Briganti, L, Evangelista, D.E. | | Deposit date: | 2020-12-15 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Unlocking the structural features for the xylobiohydrolase activity of an unusual GH11 member identified in a compost-derived consortium.
Biotechnol.Bioeng., 118, 2021
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