3KGT

V30M mutant human transthyretin (TTR) complexed with genistein (V30M:GEN) pH 7.5

Summary for 3KGT

Related3KGS 3KGU
DescriptorTransthyretin, GENISTEIN (3 entities in total)
Functional Keywordstransport protein, ttr, transthyretin, amyloid, amyloidosis, cytoplasm, disease mutation, hormone, neuropathy, polymorphism, secreted, thyroid hormone, transport
Biological sourceHomo sapiens (human)
Cellular locationSecreted P02766
Total number of polymer chains2
Total molecular weight28159.33
Authors
Trivella, D.B.,Polikarpov, I. (deposition date: 2009-10-29, release date: 2010-03-23, Last modification date: 2011-07-13)
Primary citation
Trivella, D.B.,Bleicher, L.,Palmieri, L.C.,Wiggers, H.J.,Montanari, C.A.,Kelly, J.W.,Lima, L.M.,Foguel, D.,Polikarpov, I.
Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding.
J.Struct.Biol., 170:522-531, 2010
PubMed: 20211733 (PDB entries with the same primary citation)
DOI: 10.1016/j.jsb.2010.03.002
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.245500.5%6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution