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PDB: 44 results

6UMQ
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BU of 6umq by Molmil
Structure of DUF89
Descriptor: Damage-control phosphatase DUF89, MAGNESIUM ION
Authors:Perry, J.J, Kenjic, N, Dennis, T.N.
Deposit date:2019-10-10
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Human ARMT1 structure and substrate specificity indicates that it is a DUF89 family damage-control phosphatase.
J.Struct.Biol., 212, 2020
6UMR
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BU of 6umr by Molmil
Structure of DUF89 - D291A mutant
Descriptor: Damage-control phosphatase DUF89, MAGNESIUM ION
Authors:Perry, J.J, Kenjic, N, Dennis, T.N.
Deposit date:2019-10-10
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Human ARMT1 structure and substrate specificity indicates that it is a DUF89 family damage-control phosphatase.
J.Struct.Biol., 212, 2020
2FBX
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BU of 2fbx by Molmil
WRN exonuclease, Mg complex
Descriptor: MAGNESIUM ION, Werner syndrome helicase
Authors:Perry, J.J.
Deposit date:2005-12-10
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Nat.Struct.Mol.Biol., 13, 2006
2FC0
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BU of 2fc0 by Molmil
WRN exonuclease, Mn dGMP complex
Descriptor: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, Werner syndrome helicase
Authors:Perry, J.J, Tainer, J.A.
Deposit date:2005-12-10
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Nat.Struct.Mol.Biol., 13, 2006
2FBY
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BU of 2fby by Molmil
WRN exonuclease, Eu complex
Descriptor: EUROPIUM (III) ION, Werner syndrome helicase
Authors:Perry, J.J.
Deposit date:2005-12-10
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Nat.Struct.Mol.Biol., 13, 2006
2P4K
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BU of 2p4k by Molmil
Contribution to Structure and Catalysis of Tyrosine 34 in Human Manganese Superoxide Dismutase
Descriptor: MANGANESE (II) ION, Superoxide dismutase
Authors:Perry, J.J.
Deposit date:2007-03-12
Release date:2007-04-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.
Biochemistry, 48, 2009
3GOE
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BU of 3goe by Molmil
Molecular Mimicry of SUMO promotes DNA repair
Descriptor: CALCIUM ION, DNA repair protein rad60
Authors:Perry, J.J.P.
Deposit date:2009-03-19
Release date:2009-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Molecular mimicry of SUMO promotes DNA repair.
Nat.Struct.Mol.Biol., 16, 2009
3HVC
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BU of 3hvc by Molmil
Crystal structure of human p38alpha MAP kinase
Descriptor: 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, Mitogen-activated protein kinase 14
Authors:Perry, J.J, Tainer, J.A.
Deposit date:2009-06-15
Release date:2009-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses.
J.Mol.Biol., 391, 2009
3RD2
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BU of 3rd2 by Molmil
NIP45 SUMO-like Domain 2
Descriptor: NFATC2-interacting protein
Authors:Perry, J.J.P, Arvai, A.S, Tainer, J.A.
Deposit date:2011-03-31
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.
Mol.Cell.Biol., 31, 2011
3RCZ
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BU of 3rcz by Molmil
Rad60 SLD2 Ubc9 Complex
Descriptor: DNA repair protein rad60, SUMO-conjugating enzyme ubc9
Authors:Perry, J.J.P, Arvai, A.S, Tainer, J.A.
Deposit date:2011-03-31
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.
Mol.Cell.Biol., 31, 2011
4PPE
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BU of 4ppe by Molmil
human RNF4 RING domain
Descriptor: E3 ubiquitin-protein ligase RNF4, ZINC ION
Authors:Perry, J.J, Arvai, A.S, Hitomi, C, Tainer, J.A.
Deposit date:2014-02-26
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response.
Embo Rep., 15, 2014
2FBV
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BU of 2fbv by Molmil
WRN exonuclease, Mn complex
Descriptor: MANGANESE (II) ION, Werner syndrome helicase
Authors:Perry, J.J.
Deposit date:2005-12-10
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Nat.Struct.Mol.Biol., 13, 2006
2FBT
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BU of 2fbt by Molmil
WRN exonuclease
Descriptor: ACETIC ACID, Werner syndrome helicase
Authors:Perry, J.J.
Deposit date:2005-12-10
Release date:2006-04-25
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Nat.Struct.Mol.Biol., 13, 2006
2GDS
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BU of 2gds by Molmil
Interrupting the Hydrogen Bonding Network at the Active Site of Human Manganese Superoxide Dismutase
Descriptor: MANGANESE (II) ION, Superoxide dismutase
Authors:Perry, J.J.
Deposit date:2006-03-16
Release date:2006-03-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Interrupting the Hydrogen Bond Network at the Active Site of Human Manganese Superoxide Dismutase
J.Biol.Chem., 274, 1999
8GL9
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BU of 8gl9 by Molmil
Co-crystal structure of caPCNA bound to AOH1160 derivative 1LE
Descriptor: CHLORIDE ION, N~2~-(naphthalene-1-carbonyl)-N-(2-phenoxyphenyl)-L-alpha-glutamine, Proliferating cell nuclear antigen
Authors:Jossart, J, Kenjic, N, Malkas, L.H, Hickey, R.J, Perry, J.J.
Deposit date:2023-03-21
Release date:2023-07-26
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Small molecule targeting of transcription-replication conflict for selective chemotherapy.
Cell Chem Biol, 30, 2023
8GLA
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BU of 8gla by Molmil
Co-crystal structure of caPCNA bound to the AOH1996 derivative, AOH1996-1LE
Descriptor: CHLORIDE ION, N-[2-(3-methoxyphenoxy)phenyl]-N~2~-(naphthalene-1-carbonyl)-L-alpha-glutamine, Proliferating cell nuclear antigen
Authors:Jossart, J, Perry, J.J.
Deposit date:2023-03-21
Release date:2023-07-26
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:Small molecule targeting of transcription-replication conflict for selective chemotherapy.
Cell Chem Biol, 30, 2023
3MML
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BU of 3mml by Molmil
Allophanate Hydrolase Complex from Mycobacterium smegmatis, Msmeg0435-Msmeg0436
Descriptor: Allophanate hydrolase subunit 1, Allophanate hydrolase subunit 2, CHLORIDE ION
Authors:Kaufmann, M, Chernishof, I, Shin, A, Germano, D, Sawaya, M.R, Waldo, G.S, Arbing, M.A, Perry, J, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-04-20
Release date:2010-04-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Allphanate Hydrolase Complex from M. smegmatis, Msmeg0435-Msmeg0436
To be Published
6RJP
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BU of 6rjp by Molmil
Bfl-1 in complex with alpha helical peptide
Descriptor: Bcl-2-like protein 11, Bcl-2-related protein A1
Authors:Baggio, C, Gambini, L, Udompholkul, P, Salem, A.F, Hakansson, M, Jossart, J, Perry, J, Pellecchia, M.
Deposit date:2019-04-29
Release date:2019-10-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists.
Chem.Biol.Drug Des., 95, 2020
6VBX
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BU of 6vbx by Molmil
Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist
Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, Synthetic peptide
Authors:Pellecchia, M, Perry, J.J, Kenjic, N, Assar, Z.
Deposit date:2019-12-19
Release date:2020-12-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1.
J.Med.Chem., 64, 2021
6WML
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BU of 6wml by Molmil
Human TLR8 bound to the potent agonist, GS-9688 (Selgantolimod)
Descriptor: (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ...
Authors:Appleby, T.C, Perry, J.K, Mish, M, Villasenor, A.G, Mackman, R.L.
Deposit date:2020-04-21
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
J.Med.Chem., 63, 2020
7UO4
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BU of 7uo4 by Molmil
SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A.
Deposit date:2022-04-12
Release date:2022-11-30
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Structural basis for substrate selection by the SARS-CoV-2 replicase.
Nature, 614, 2023
7UOB
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BU of 7uob by Molmil
SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state
Descriptor: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A.
Deposit date:2022-04-12
Release date:2022-11-30
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Structural basis for substrate selection by the SARS-CoV-2 replicase.
Nature, 614, 2023
7UO9
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BU of 7uo9 by Molmil
SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A.
Deposit date:2022-04-12
Release date:2022-11-30
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structural basis for substrate selection by the SARS-CoV-2 replicase.
Nature, 614, 2023
7UO7
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BU of 7uo7 by Molmil
SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-structural protein 7, ...
Authors:Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A.
Deposit date:2022-04-12
Release date:2022-11-30
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Structural basis for substrate selection by the SARS-CoV-2 replicase.
Nature, 614, 2023
7UOE
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BU of 7uoe by Molmil
SARS-CoV-2 replication-transcription complex bound to CTP, in a pre-catalytic state
Descriptor: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A.
Deposit date:2022-04-12
Release date:2022-11-30
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.67 Å)
Cite:Structural basis for substrate selection by the SARS-CoV-2 replicase.
Nature, 614, 2023

 

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