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PDB: 56 results

1IK9
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CRYSTAL STRUCTURE OF A XRCC4-DNA LIGASE IV COMPLEX
Descriptor: DNA LIGASE IV, DNA REPAIR PROTEIN XRCC4
Authors:Sibanda, B.L, Critchlow, S.E, Begun, J, Pei, X.Y, Jackson, S.P, Blundell, T.L, Pellegrini, L.
Deposit date:2001-05-03
Release date:2001-11-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of an Xrcc4-DNA ligase IV complex.
Nat.Struct.Biol., 8, 2001
1PWA
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Crystal structure of Fibroblast Growth Factor 19
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Fibroblast growth factor-19, GLYCEROL, ...
Authors:Harmer, N.J, Pellegrini, L, Chirgadze, D, Fernandez-Recio, J, Blundell, T.L.
Deposit date:2003-07-01
Release date:2004-01-27
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity.
Biochemistry, 43, 2004
1Z56
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BU of 1z56 by Molmil
Co-Crystal Structure of Lif1p-Lig4p
Descriptor: DNA ligase IV, Ligase interacting factor 1
Authors:Dore, A.S, Furnham, N, Davies, O.R, Sibanda, B.L, Chirgadze, D.Y, Jackson, S.P, Pellegrini, L, Blundell, T.L.
Deposit date:2005-03-17
Release date:2006-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA REPAIR, 5, 2006
1ZT2
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BU of 1zt2 by Molmil
Heterodimeric structure of the core primase.
Descriptor: DNA primase large subunit, DNA primase small subunit, SULFATE ION, ...
Authors:Lao-Sirieix, S.H, Nookala, R.K, Roversi, P, Bell, S.D, Pellegrini, L.
Deposit date:2005-05-26
Release date:2005-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Structure of the heterodimeric core primase.
Nat.Struct.Mol.Biol., 12, 2005
8QJ7
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BU of 8qj7 by Molmil
Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ...
Authors:Yin, Z, Pellegrini, L.
Deposit date:2023-09-12
Release date:2024-02-21
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:CryoEM insights into RNA primer synthesis by the human primosome.
Febs J., 291, 2024
6XTX
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CryoEM structure of human CMG bound to ATPgammaS and DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45 homolog, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ...
Authors:Rzechorzek, N.J, Pellegrini, L.
Deposit date:2020-01-16
Release date:2020-05-27
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes.
Nucleic Acids Res., 48, 2020
6XTY
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CryoEM structure of human CMG bound to AND-1 (CMGA)
Descriptor: Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Rzechorzek, N.J, Pellegrini, L, Chirgadze, D.Y, Hardwick, S.W.
Deposit date:2020-01-16
Release date:2020-05-27
Last modified:2024-09-25
Method:ELECTRON MICROSCOPY (6.77 Å)
Cite:CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes.
Nucleic Acids Res., 48, 2020
5NXQ
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Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to a stapled Sld5 CIP
Descriptor: DNA polymerase alpha-binding protein, GLYCEROL, MET-ASP-ILE-UA1-ILE-ASP-ASP-ILE-LEU-UA2-GLU-LEU-ASP-LYS-GLU
Authors:Wu, Y, Pellegrini, L.
Deposit date:2017-05-10
Release date:2017-08-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.413 Å)
Cite:Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
Angew. Chem. Int. Ed. Engl., 56, 2017
4FVM
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Crystal structure of yeast DNA polymerase alpha
Descriptor: DNA polymerase alpha catalytic subunit A
Authors:Perera, R.L, Pellegrini, L.
Deposit date:2012-06-29
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
eLife, 2, 2013
4FXD
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BU of 4fxd by Molmil
Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA
Descriptor: DNA (5'-D(*TP*TP*TP*TP*CP*GP*CP*TP*GP*CP*CP*CP*GP*CP*CP*T)-3'), DNA polymerase alpha catalytic subunit A, RNA (5'-R(*AP*GP*GP*CP*GP*GP*GP*CP*AP*G)-3')
Authors:Perera, R.L, Torella, R, Klinge, S, Kilkenny, M.L, Maman, J.D, Pellegrini, L.
Deposit date:2012-07-03
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
eLife, 2, 2013
4FYD
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Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA and dGTP
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*GP*AP*GP*CP*GP*TP*G*TP*GP*TP*AP*CP*CP*CP*CP*TP*GP*CP*CP*CP*GP*CP*CP*G)-3'), DNA polymerase alpha catalytic subunit A, ...
Authors:Perera, R.L, Pellegrini, L.
Deposit date:2012-07-04
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
eLife, 2, 2013
5DGO
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BU of 5dgo by Molmil
Crystal structure of cell division cycle protein 45 (Cdc45)
Descriptor: 1,2-ETHANEDIOL, Cell division control protein 45 homolog, SULFATE ION
Authors:Simon, A.C, Pellegrini, L.
Deposit date:2015-08-28
Release date:2016-05-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of human Cdc45 and implications for CMG helicase function.
Nat Commun, 7, 2016
6TAZ
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BU of 6taz by Molmil
Timeless couples G quadruplex detection with processing by DDX11 during DNA replication
Descriptor: Protein timeless homolog
Authors:Lerner Koch, L, Holzer, S, Kilkenny, M.L, Murat, P, Svikovic, S, Schiavone, D, Bittleston, A, Maman, J.D, Branzei, D, Stott, K, Pellegrini, L, Sale, E.J.
Deposit date:2019-10-31
Release date:2020-07-01
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
Embo J., 39, 2020
6R4T
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BU of 6r4t by Molmil
Crystal structure of the Pri1 subunit of human primase bound to vidarabine triphosphate
Descriptor: 1,2-ETHANEDIOL, 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-amine, DNA primase small subunit, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-03-24
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R5E
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BU of 6r5e by Molmil
Crystal structure of the Pri1 subunit of human primase bound to 2F-ATP
Descriptor: 1,2-ETHANEDIOL, 2-fluoro-ATP, DNA primase small subunit, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-03-24
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R4U
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BU of 6r4u by Molmil
Crystal structure of the Pri1 subunit of human primase bound to fludarabine triphosphate
Descriptor: 1,2-ETHANEDIOL, 2-fluoro-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-a mine, DNA primase small subunit, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-03-24
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
4C8H
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BU of 4c8h by Molmil
Crystal structure of the C-terminal region of yeast Ctf4, selenomethionine protein.
Descriptor: CTF4
Authors:Simon, A.C, Pellegrini, L.
Deposit date:2013-10-01
Release date:2014-04-30
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.691 Å)
Cite:A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase Alpha in the Eukaryotic Replisome
Nature, 510, 2014
4C93
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BU of 4c93 by Molmil
Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Pol alpha.
Descriptor: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A, DNA POLYMERASE ALPHA-BINDING PROTEIN
Authors:Simon, A.C, Pellegrini, L.
Deposit date:2013-10-02
Release date:2014-04-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.694 Å)
Cite:A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
4C95
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Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Sld5
Descriptor: DNA POLYMERASE ALPHA-BINDING PROTEIN, DNA REPLICATION COMPLEX GINS PROTEIN SLD5
Authors:Simon, A.C, Pellegrini, L.
Deposit date:2013-10-02
Release date:2014-04-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.694 Å)
Cite:A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
4C8S
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BU of 4c8s by Molmil
Crystal structure of the C-terminal region of yeast Ctf4
Descriptor: DNA POLYMERASE ALPHA-BINDING PROTEIN
Authors:Simon, A.C, Pellegrini, L.
Deposit date:2013-10-01
Release date:2014-04-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
6RB4
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BU of 6rb4 by Molmil
Crystal structure of the Pri1 subunit of human primase
Descriptor: 1,2-ETHANEDIOL, DNA primase small subunit, ZINC ION
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-04-09
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R5D
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BU of 6r5d by Molmil
Crystal structure of the Pri1 subunit of human primase bound to dATP
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA primase small subunit, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-03-24
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R4S
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BU of 6r4s by Molmil
Crystal structure of the Pri1 subunit of human primase bound to ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA primase small subunit, MANGANESE (II) ION, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-03-24
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
5MQI
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BU of 5mqi by Molmil
Crystal structure of the N-terminal domain of human Timeless
Descriptor: Protein timeless homolog,Protein timeless homolog, SULFATE ION
Authors:Holzer, S, Kilkenny, M.L, Pellegrini, L.
Deposit date:2016-12-20
Release date:2017-03-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.847 Å)
Cite:Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.
Nucleic Acids Res., 45, 2017
4B08
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Yeast DNA polymerase alpha, Selenomethionine protein
Descriptor: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A
Authors:Perera, R.L, Torella, R, Klinge, S, Kilkenny, M.L, Maman, J.D, Pellegrini, L.
Deposit date:2012-06-29
Release date:2013-02-27
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Mechanism for Priming DNA Synthesis by Yeast DNA Polymerase Alpha
Elife, 2, 2013

226707

数据于2024-10-30公开中

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