6N7Y
 
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6N83
 | | Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037 | | Descriptor: | CHLORIDE ION, Farnesyl pyrophosphate synthase, PHOSPHATE ION, ... | | Authors: | Park, J, Schilling, M.A, Berghuis, A.M. | | Deposit date: | 2018-11-28 | | Release date: | 2019-11-06 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
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6N7Z
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6OAH
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8IS8
 | | CrtMLIKE with two GsPP molecules | | Descriptor: | CrtM, GERANYL S-THIOLODIPHOSPHATE, MAGNESIUM ION | | Authors: | Park, J.y. | | Deposit date: | 2023-03-20 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | CrtMLIKE with two GsPP molecules
To Be Published
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8IS6
 | | Apo-CrtMLIKE | | Descriptor: | CrtM | | Authors: | Park, J.Y. | | Deposit date: | 2023-03-20 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | CrtMKLIKE Apo structure
To Be Published
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7SVU
 | | TnsBctd-TnsC-TniQ complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (28-MER), DNA (29-MER), ... | | Authors: | Park, J, Tsai, A.W.T, Kellogg, E.H. | | Deposit date: | 2021-11-19 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of the holo CRISPR RNA-guided transposon integration complex
Nature, 613, 2023
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4QXS
 | | Crystal structure of human FPPS in complex with WC01088 | | Descriptor: | (2-{2-[(2S)-3-methylbutan-2-yl]-5-phenyl-1H-indol-3-yl}ethane-1,1-diyl)bis(phosphonic acid), Farnesyl pyrophosphate synthase, GLYCEROL, ... | | Authors: | Park, J, Zielinski, M, Weiling, C, Tsantrizos, Y.S, Berghuis, A.M. | | Deposit date: | 2014-07-21 | | Release date: | 2015-02-25 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.
Bioorg.Med.Chem.Lett., 25, 2015
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4QY5
 | | Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations | | Descriptor: | Beta-lactamase TEM,Beta-lactamase PSE-4, CHLORIDE ION, MAGNESIUM ION | | Authors: | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | | Deposit date: | 2014-07-23 | | Release date: | 2015-08-12 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.501 Å) | | Cite: | Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations
To be Published
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6WJZ
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6WK0
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5TUF
 | | Crystal structure of tetracycline destructase Tet(50) in complex with anhydrotetracycline | | Descriptor: | 5A,6-ANHYDROTETRACYCLINE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... | | Authors: | Park, J, Tolia, N.H. | | Deposit date: | 2016-11-06 | | Release date: | 2017-05-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
Nat. Chem. Biol., 13, 2017
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4DEM
 | | Crystal structure of human FPPS in complex with YS_04_70 | | Descriptor: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid) | | Authors: | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | | Deposit date: | 2012-01-20 | | Release date: | 2012-03-21 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells.
J.Med.Chem., 55, 2012
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5TUK
 | | Crystal structure of tetracycline destructase Tet(51) | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Tetracycline destructase Tet(51) | | Authors: | Park, J, Tolia, N.H. | | Deposit date: | 2016-11-06 | | Release date: | 2017-05-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
Nat. Chem. Biol., 13, 2017
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5TUI
 | | Crystal structure of tetracycline destructase Tet(50) in complex with chlortetracycline | | Descriptor: | 7-CHLOROTETRACYCLINE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... | | Authors: | Park, J, Tolia, N.H. | | Deposit date: | 2016-11-06 | | Release date: | 2017-05-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
Nat. Chem. Biol., 13, 2017
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5TUE
 | | Crystal structure of tetracycline destructase Tet(50) | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, Tetracycline destructase Tet(50) | | Authors: | Park, J, Tolia, N.H. | | Deposit date: | 2016-11-05 | | Release date: | 2017-05-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
Nat. Chem. Biol., 13, 2017
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5JA0
 | | Crystal structure of human FPPS with allosterically bound FPP | | Descriptor: | FARNESYL DIPHOSPHATE, Farnesyl pyrophosphate synthase, PHOSPHATE ION | | Authors: | Park, J, Zielinski, M, Tsantrizos, Y.S, Berghuis, A.M. | | Deposit date: | 2016-04-11 | | Release date: | 2017-01-25 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.
Nat Commun, 8, 2017
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5TUM
 | | Crystal structure of tetracycline destructase Tet(56) | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, tetracycline destructase Tet(56) | | Authors: | Park, J, Tolia, N.H. | | Deposit date: | 2016-11-06 | | Release date: | 2017-05-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.299 Å) | | Cite: | Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
Nat. Chem. Biol., 13, 2017
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5TUL
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6C57
 | | Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with bisphosphonate inhibitor FV0109 | | Descriptor: | Geranylgeranyl pyrophosphate synthase, {[(2-{3-[(4-fluorobenzene-1-carbonyl)amino]phenyl}thieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic acid) | | Authors: | Park, J, Bin, X, Vincent, F, Tsantrizos, Y.S, Berghuis, A.M. | | Deposit date: | 2018-01-15 | | Release date: | 2018-09-05 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
J. Med. Chem., 61, 2018
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6C56
 | | Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in its Apo form | | Descriptor: | Geranylgeranyl pyrophosphate synthase, {[(2-phenylthieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic acid) | | Authors: | Park, J, Ta, V, Tsantrizos, Y.S, Berghuis, A.M. | | Deposit date: | 2018-01-15 | | Release date: | 2018-09-05 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
J. Med. Chem., 61, 2018
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8UDK
 | | Human Mitochondrial DNA Polymerase gamma R853A Ternary Complex | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (24-MER), DNA (28-MER), ... | | Authors: | Park, J, Herrmann, G.K, Yin, Y.W. | | Deposit date: | 2023-09-28 | | Release date: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (3.43 Å) | | Cite: | An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in Pol gamma.
Sci Adv, 10, 2024
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8UDL
 | | Human Mitochondrial DNA Polymerase Gamma Binary Complex | | Descriptor: | DNA (5'-D(P*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*TP*AP*C)-3'), DNA (5'-D(P*AP*GP*GP*TP*AP*TP*GP*GP*CP*AP*CP*TP*GP*GP*CP*CP*GP*TP*CP*GP*TP*TP*TP*T)-3'), DNA polymerase subunit gamma-1, ... | | Authors: | Park, J, Yin, Y.W. | | Deposit date: | 2023-09-28 | | Release date: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.37 Å) | | Cite: | An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in Pol gamma.
Sci Adv, 10, 2024
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8IS7
 | | CrtMLIKE with two FsPP molecules. | | Descriptor: | CrtM, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE | | Authors: | Park, J.Y. | | Deposit date: | 2023-03-20 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | CrtMLIKE with two FsPP molecules.
To Be Published
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8ISA
 | | CrtMLIKE with one GsPP molecule | | Descriptor: | CrtM, GERANYL S-THIOLODIPHOSPHATE | | Authors: | Park, J.Y. | | Deposit date: | 2023-03-20 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | CrtMLIKE with one GsPP molecule
To Be Published
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