6VIZ
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![BU of 6viz by Molmil](/molmil-images/mine/6viz) | BRD4_Bromodomain1 complex with pyrrolopyridone compound 27 | Descriptor: | 4-[2-(2,6-dimethylphenoxy)-5-(ethylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, Bromodomain-containing protein 4 | Authors: | Longenecker, K.L, Park, C.H, Qiu, W. | Deposit date: | 2020-01-14 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.391 Å) | Cite: | Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63, 2020
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6VIW
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![BU of 6viw by Molmil](/molmil-images/mine/6viw) | BRD4_Bromodomain1 complex with pyrrolopyridone compound 18 | Descriptor: | 4-[2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, Bromodomain-containing protein 4 | Authors: | Longenecker, K.L, Park, C.H, Qiu, W. | Deposit date: | 2020-01-14 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.429 Å) | Cite: | Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63, 2020
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6VIX
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![BU of 6vix by Molmil](/molmil-images/mine/6vix) | BRD4_Bromodomain2 complex with pyrrolopyridone compound 18 | Descriptor: | 4-[2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, Bromodomain-containing protein 4 | Authors: | Longenecker, K.L, Park, C.H, Qiu, W. | Deposit date: | 2020-01-14 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.116 Å) | Cite: | Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63, 2020
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4ZZ7
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![BU of 4zz7 by Molmil](/molmil-images/mine/4zz7) | Crystal structure of methylmalonate-semialdehyde dehydrogenase (DddC) from Oceanimonas doudoroffii | Descriptor: | Methylmalonate-semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Do, H, Lee, C.W, Lee, S.G, Kang, H, Park, C.M, Kim, H.J, Park, H, Park, H, Lee, J.H. | Deposit date: | 2015-05-22 | Release date: | 2016-04-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure and modeling of the tetrahedral intermediate state of methylmalonate-semialdehyde dehydrogenase (MMSDH) from Oceanimonas doudoroffii. J. Microbiol., 54, 2016
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6VIY
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![BU of 6viy by Molmil](/molmil-images/mine/6viy) | BRD2_Bromodomain2 complex with pyrrolopyridone compound 27 | Descriptor: | 4-[2-(2,6-dimethylphenoxy)-5-(ethylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, Bromodomain-containing protein 2 | Authors: | Longenecker, K.L, Park, C.H, Qiu, W. | Deposit date: | 2020-01-14 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.904 Å) | Cite: | Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63, 2020
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1OQN
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![BU of 1oqn by Molmil](/molmil-images/mine/1oqn) | Crystal structure of the phosphotyrosine binding domain (PTB) of mouse Disabled 1 (Dab1) | Descriptor: | Alzheimer's disease amyloid A4 protein homolog, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Disabled homolog 1 | Authors: | Yun, M, Keshvara, L, Park, C.-G, Zhang, Y.-M, Dickerson, J.B, Zheng, J, Rock, C.O, Curran, T, Park, H.-W. | Deposit date: | 2003-03-10 | Release date: | 2003-08-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of the Dab homology domains of mouse disabled 1 and 2 J.Biol.Chem., 278, 2003
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1M7E
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![BU of 1m7e by Molmil](/molmil-images/mine/1m7e) | Crystal structure of the phosphotyrosine binding domain(PTB) of mouse Disabled 2(Dab2):implications for Reeling signaling | Descriptor: | Disabled homolog 2, NGYENPTYK peptide | Authors: | Yun, M, Keshvara, L, Park, C.-G, Zhang, Y.-M, Dickerson, J.B, Zheng, J, Rock, C.O, Curran, T, Park, H.-W. | Deposit date: | 2002-07-19 | Release date: | 2003-08-05 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structures of the Dab homology domains of mouse disabled 1 and 2 J.Biol.Chem., 278, 2003
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2VQY
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![BU of 2vqy by Molmil](/molmil-images/mine/2vqy) | Structure of AAC(6')-Ib in complex with Parmomycin and AcetylCoA. | Descriptor: | AAC(6')-IB, ACETYL COENZYME *A, CALCIUM ION, ... | Authors: | Vetting, M.W, Park, C.H, Hedge, S.S, Hooper, D.C, Blanchard, J.S. | Deposit date: | 2008-03-20 | Release date: | 2008-09-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant. Biochemistry, 47, 2008
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1N6M
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![BU of 1n6m by Molmil](/molmil-images/mine/1n6m) | Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Claret segregational protein, MAGNESIUM ION | Authors: | Yun, M, Bronner, C.E, Park, C.-G, Cha, S.-S, Park, H.-W, Endow, S.A. | Deposit date: | 2002-11-11 | Release date: | 2003-10-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd EMBO J., 22, 2003
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1P3R
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![BU of 1p3r by Molmil](/molmil-images/mine/1p3r) | Crystal structure of the phosphotyrosin binding domain(PTB) of mouse Disabled 1(Dab1) | Descriptor: | Disabled homolog 2 | Authors: | Yun, M, Keshvara, L, Park, C.G, Zhang, Y.M, Dickerson, J.B, Zheng, J, Rock, C.O, Curran, T, Park, H.W. | Deposit date: | 2003-04-18 | Release date: | 2003-08-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J.Biol.Chem., 278, 2003
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1F9T
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![BU of 1f9t by Molmil](/molmil-images/mine/1f9t) | CRYSTAL STRUCTURES OF KINESIN MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE MOTOR ATPASE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | Authors: | Yun, M, Zhang, X, Park, C.-G, Park, H.-W, Endow, S.A. | Deposit date: | 2000-07-11 | Release date: | 2001-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A structural pathway for activation of the kinesin motor ATPase. EMBO J., 20, 2001
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7XX9
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![BU of 7xx9 by Molmil](/molmil-images/mine/7xx9) | |
7XX8
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![BU of 7xx8 by Molmil](/molmil-images/mine/7xx8) | |
4C3G
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![BU of 4c3g by Molmil](/molmil-images/mine/4c3g) | cryo-EM structure of activated and oligomeric restriction endonuclease SgrAI | Descriptor: | 5'-D(*CP*CP*GP*GP*TP*GP*TP*GP*AP*AP*GP*AP*CP*CP *CP*AP*CP*GP*CP*AP*TP*CP)-3', 5'-D(*GP*AP*TP*GP*CP*GP*TP*GP*GP*GP*TP*CP*TP*TP *CP*AP*CP*AP)-3', SGRAIR RESTRICTION ENZYME | Authors: | Lyumkis, D, Talley, H, Stewart, A, Shah, S, Park, C.K, Tama, F, Potter, C.S, Carragher, B, Horton, N.C. | Deposit date: | 2013-08-23 | Release date: | 2013-09-11 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (8.6 Å) | Cite: | Allosteric Regulation of DNA Cleavage and Sequence-Specificity Through Run-on Oligomerization. Structure, 21, 2013
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1ESN
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![BU of 1esn by Molmil](/molmil-images/mine/1esn) | STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A | Descriptor: | MAGNESIUM ION, PANTOTHENATE KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Yun, M, Park, C.G, Kim, J.Y, Rock, C.O, Jackowski, S, Park, H.W. | Deposit date: | 2000-04-10 | Release date: | 2000-11-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A. J.Biol.Chem., 275, 2000
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1ESM
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![BU of 1esm by Molmil](/molmil-images/mine/1esm) | STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A | Descriptor: | COENZYME A, PANTOTHENATE KINASE | Authors: | Yun, M, Park, C.G, Kim, J.Y, Rock, C.O, Jackowski, S, Park, H.W. | Deposit date: | 2000-04-10 | Release date: | 2000-09-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A. J.Biol.Chem., 275, 2000
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4C9F
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![BU of 4c9f by Molmil](/molmil-images/mine/4c9f) | Structure of SIGN-R1 in complex with Sulfodextran | Descriptor: | 4-O-sulfo-alpha-D-glucopyranose, CALCIUM ION, CD209 ANTIGEN-LIKE PROTEIN B, ... | Authors: | Silva-Martin, N, Bartual, S.G, Rodriguez, A, Ramirez, E, Chacon, P, Anthony, R.M, Park, C.G, Hermoso, J.A. | Deposit date: | 2013-10-02 | Release date: | 2014-10-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Basis for Selective Recognition of Endogenous and Microbial Polysaccharides by Macrophage Receptor Sign-R1 Structure, 22, 2014
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1F9W
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![BU of 1f9w by Molmil](/molmil-images/mine/1f9w) | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | Authors: | Yun, M, Zhang, X, Park, C.G, Park, H.W, Endow, S.A. | Deposit date: | 2000-07-11 | Release date: | 2001-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A structural pathway for activation of the kinesin motor ATPase. EMBO J., 20, 2001
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1F9U
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![BU of 1f9u by Molmil](/molmil-images/mine/1f9u) | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | Authors: | Yun, M, Zhang, X, Park, C.G, Park, H.W, Endow, S.A. | Deposit date: | 2000-07-11 | Release date: | 2001-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A structural pathway for activation of the kinesin motor ATPase. EMBO J., 20, 2001
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1F9V
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![BU of 1f9v by Molmil](/molmil-images/mine/1f9v) | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | Authors: | Yun, M, Zhang, X, Park, C.G, Park, H.W, Endow, S.A. | Deposit date: | 2000-07-11 | Release date: | 2001-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | A structural pathway for activation of the kinesin motor ATPase. EMBO J., 20, 2001
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1JLK
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![BU of 1jlk by Molmil](/molmil-images/mine/1jlk) | Crystal structure of the Mn(2+)-bound form of response regulator Rcp1 | Descriptor: | MANGANESE (II) ION, Response regulator RCP1, SULFATE ION | Authors: | Im, Y.J, Rho, S.-H, Park, C.-M, Yang, S.-S, Kang, J.-G, Lee, J.Y, Song, P.-S, Eom, S.H. | Deposit date: | 2001-07-16 | Release date: | 2002-03-13 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of a cyanobacterial phytochrome response regulator. Protein Sci., 11, 2002
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7WCG
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![BU of 7wcg by Molmil](/molmil-images/mine/7wcg) | |
1MFY
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![BU of 1mfy by Molmil](/molmil-images/mine/1mfy) | SOLUTION STRUCTURE OF INFLUENZA A VIRUS C4 PROMOTER | Descriptor: | C4 promoter of influneza A virus | Authors: | Lee, M.-K, Bae, S.-H, Park, C.-J, Cheong, H.-K, Cheong, C, Choi, B.-S. | Deposit date: | 2002-08-14 | Release date: | 2002-09-18 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A single-nucleotide natural variation (U4 to C4) in an influenza A virus promoter exhibits a large structural change: implications for differential viral RNA synthesis by RNA-dependent RNA polymerase. Nucleic Acids Res., 31, 2003
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4N8M
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![BU of 4n8m by Molmil](/molmil-images/mine/4n8m) | Structural polymorphism in the N-terminal oligomerization domain of NPM1 | Descriptor: | COBALT (II) ION, Nucleophosmin | Authors: | Mitrea, D, Royappa, G, Buljan, M, Yun, M, Pytel, N, Satumba, J, Nourse, A, Park, C, Babu, M.M, White, S.W, Kriwacki, R.W. | Deposit date: | 2013-10-17 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Structural polymorphism in the N-terminal oligomerization domain of NPM1. Proc.Natl.Acad.Sci.USA, 111, 2014
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1GUB
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![BU of 1gub by Molmil](/molmil-images/mine/1gub) | Hinge-bending motion of D-allose binding protein from Escherichia coli: three open conformations | Descriptor: | D-ALLOSE-BINDING PERIPLASMIC PROTEIN, NICKEL (II) ION | Authors: | Magnusson, U, Chaudhuri, B.N, Ko, J, Park, C, Jones, T.A, Mowbray, S.L. | Deposit date: | 2002-01-24 | Release date: | 2003-03-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of D-Allose Binding Protein from Escherichia Coli Bound to D-Allose at 1.8 A Resolution J.Mol.Biol., 286, 1999
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