6VIY

BRD2_Bromodomain2 complex with pyrrolopyridone compound 27

Summary for 6VIY

Entry DOI	10.2210/pdb6viy/pdb
Descriptor	Bromodomain-containing protein 2, 4-[2-(2,6-dimethylphenoxy)-5-(ethylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (3 entities in total)
Functional Keywords	bromodomain, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	26875.88
Authors	Longenecker, K.L.,Park, C.H.,Qiu, W. (deposition date: 2020-01-14, release date: 2020-05-06, Last modification date: 2023-10-11)
Primary citation	Sheppard, G.S.,Wang, L.,Fidanze, S.D.,Hasvold, L.A.,Liu, D.,Pratt, J.K.,Park, C.H.,Longenecker, K.,Qiu, W.,Torrent, M.,Kovar, P.J.,Bui, M.,Faivre, E.,Huang, X.,Lin, X.,Wilcox, D.,Zhang, L.,Shen, Y.,Albert, D.H.,Magoc, T.J.,Rajaraman, G.,Kati, W.M.,McDaniel, K.F. Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63:5585-5623, 2020 Cited by PubMed: 32324999 DOI: 10.1021/acs.jmedchem.0c00628 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.904 Å)

Structure validation