4LAP
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4L6B
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8VDY
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![BU of 8vdy by Molmil](/molmil-images/mine/8vdy) | Crystal Structure of Delta 114-117 D-Dopachrome Tautomerase (D-DT) | 分子名称: | D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8VFL
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![BU of 8vfl by Molmil](/molmil-images/mine/8vfl) | Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 290K | 分子名称: | D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-21 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8VFK
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![BU of 8vfk by Molmil](/molmil-images/mine/8vfk) | Crystal Structure of Delta 109-117 D-Dopachrome Tautomerase (D-DT) | 分子名称: | CITRATE ANION, D-dopachrome decarboxylase, SODIUM ION | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-21 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8VG8
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![BU of 8vg8 by Molmil](/molmil-images/mine/8vg8) | Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT) Bound to 4CPPC | 分子名称: | 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-23 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8VFN
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![BU of 8vfn by Molmil](/molmil-images/mine/8vfn) | Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 310K | 分子名称: | D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-21 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8VG7
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![BU of 8vg7 by Molmil](/molmil-images/mine/8vg7) | Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT) | 分子名称: | D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-23 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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6RPN
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![BU of 6rpn by Molmil](/molmil-images/mine/6rpn) | Structure of metallo beta lactamase VIM-2 with cyclic boronate APC308. | 分子名称: | (3~{R})-2,2-bis(oxidanyl)-3-(phenylmethylsulfanyl)-3,4-dihydro-1,2-benzoxaborinin-2-ium-8-carboxylic acid, (3~{S})-2,2-bis(oxidanyl)-3-(phenylmethylsulfanyl)-3,4-dihydro-1,2-benzoxaborinin-2-ium-8-carboxylic acid, Beta-lactamase VIM-2, ... | 著者 | Parkova, A, Lucic, A, Brem, J, McDonough, M.A, Langley, G.W, Schofield, C.J. | 登録日 | 2019-05-14 | 公開日 | 2020-03-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.409 Å) | 主引用文献 | Broad Spectrum beta-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate. Acs Infect Dis., 6, 2020
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8VG5
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![BU of 8vg5 by Molmil](/molmil-images/mine/8vg5) | Crystal Structure of V113N Variant of D-Dopachrome Tautomerase (D-DT) Bound with 4CPPC | 分子名称: | 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, CITRIC ACID, D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-22 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8VFO
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![BU of 8vfo by Molmil](/molmil-images/mine/8vfo) | Crystal Structure of L117G Variant of D-Dopachrome Tautomerase (D-DT) | 分子名称: | CITRIC ACID, D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-21 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8VFW
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![BU of 8vfw by Molmil](/molmil-images/mine/8vfw) | Crystal Structure of V113N D-Dopachrome Tautomerase (D-DT) | 分子名称: | CITRIC ACID, D-dopachrome decarboxylase | 著者 | Parkins, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-22 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8DBB
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![BU of 8dbb by Molmil](/molmil-images/mine/8dbb) | Crystal structure of DDT with the selective inhibitor 2,5-Pyridinedicarboxylic Acid | 分子名称: | CITRIC ACID, D-dopachrome decarboxylase, pyridine-2,5-dicarboxylic acid | 著者 | Parkins, A, Banumathi, S, Pantouris, G. | 登録日 | 2022-06-14 | 公開日 | 2023-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | 2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase. Structure, 31, 2023
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4R3R
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![BU of 4r3r by Molmil](/molmil-images/mine/4r3r) | Crystal structures of EGFR in complex with Mig6 | 分子名称: | Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1' | 著者 | Park, E, Kim, N, Yi, Z, Cho, A, Kim, K, Ficarro, S.B, Park, A, Park, W.Y, Murray, B, Meyerson, M, Beroukim, R, Marto, J.A, Cho, J, Eck, M.J. | 登録日 | 2014-08-17 | 公開日 | 2015-08-12 | 最終更新日 | 2015-09-16 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat.Struct.Mol.Biol., 22, 2015
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4R3P
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![BU of 4r3p by Molmil](/molmil-images/mine/4r3p) | Crystal structures of EGFR in complex with Mig6 | 分子名称: | Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1 | 著者 | Park, E, Kim, N, Yi, Z, Cho, A, Kim, K, Ficarro, S.B, Park, A, Park, W.Y, Murray, B, Meyerson, M, Beroukim, R, Marto, J.A, Cho, J, Eck, M.J. | 登録日 | 2014-08-17 | 公開日 | 2015-08-12 | 最終更新日 | 2015-09-16 | 実験手法 | X-RAY DIFFRACTION (2.905 Å) | 主引用文献 | Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat.Struct.Mol.Biol., 22, 2015
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1XGK
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![BU of 1xgk by Molmil](/molmil-images/mine/1xgk) | CRYSTAL STRUCTURE OF N12G AND A18G MUTANT NMRA | 分子名称: | CHLORIDE ION, GLYCEROL, NITROGEN METABOLITE REPRESSION REGULATOR NMRA, ... | 著者 | Lamb, H.K, Ren, J, Park, A, Johnson, C, Leslie, K, Cocklin, S, Thompson, P, Mee, C, Cooper, A, Stammers, D.K, Hawkins, A.R. | 登録日 | 2004-09-17 | 公開日 | 2004-12-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis Protein Sci., 13, 2004
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7TOQ
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![BU of 7toq by Molmil](/molmil-images/mine/7toq) | Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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7TOP
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![BU of 7top by Molmil](/molmil-images/mine/7top) | Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein PR20 | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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7TOS
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![BU of 7tos by Molmil](/molmil-images/mine/7tos) | E. coli 70S ribosomes bound with the ALS/FTD-associated dipeptide repeat protein PR20 | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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7TOR
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![BU of 7tor by Molmil](/molmil-images/mine/7tor) | Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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7TOO
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![BU of 7too by Molmil](/molmil-images/mine/7too) | Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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4ZMS
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![BU of 4zms by Molmil](/molmil-images/mine/4zms) | Structure of the full-length response regulator spr1814 in complex with a phosphate analogue and B3C | 分子名称: | 5-amino-2,4,6-tribromobenzene-1,3-diyl dihydroperoxide, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | 著者 | Chi, Y.M, Park, A. | 登録日 | 2015-05-04 | 公開日 | 2016-04-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural characterization of the full-length response regulator spr1814 in complex with a phosphate analogue reveals a novel conformational plasticity of the linker region Biochem.Biophys.Res.Commun., 473, 2016
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4ZMR
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7V0J
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![BU of 7v0j by Molmil](/molmil-images/mine/7v0j) | Crystal structure of a CelR catalytic domain active site mutant with bound cellobiose product | 分子名称: | CALCIUM ION, Glucanase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | 著者 | Bingman, C.A, Kuch, N, Kutsche, M.E, Parker, A, Smith, R.W, Fox, B.G. | 登録日 | 2022-05-10 | 公開日 | 2023-04-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Contribution of calcium ligands in substrate binding and product release in the Acetovibrio thermocellus glycoside hydrolase family 9 cellulase CelR. J.Biol.Chem., 299, 2023
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7UNP
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![BU of 7unp by Molmil](/molmil-images/mine/7unp) | Crystal structure of the CelR catalytic domain and CBM3c | 分子名称: | CALCIUM ION, Glucanase | 著者 | Bingman, C.A, Kuch, N, Kutsche, M.E, Parker, A, Smith, R.W, Fox, B.G. | 登録日 | 2022-04-11 | 公開日 | 2023-04-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Contribution of calcium ligands in substrate binding and product release in the Acetovibrio thermocellus glycoside hydrolase family 9 cellulase CelR. J.Biol.Chem., 299, 2023
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