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PDB: 66 件
4INH
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Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus
分子名称: DIMETHYL SULFOXIDE, Genome polyprotein, peptide inhibitor, ...
著者Prasad, B.V.V, Muhaxhiri, Z, Deng, L, Shanker, S, Sankaran, B, Estes, M.K, Palzkill, T, Song, Y.
登録日2013-01-04
公開日2013-02-20
最終更新日2013-04-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis of substrate specificity and protease inhibition in norwalk virus.
J.Virol., 87, 2013
4PM5
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BU of 4pm5 by Molmil
Crystal structure of CTX-M-14 S70G beta-lactamase in complex with cefotaxime at 1.26 Angstroms resolution
分子名称: (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid, Beta-lactamase CTX-M-14, SULFATE ION
著者Adamski, C.J, Cardenas, A.M, Sankaran, B, Palzkill, T.
登録日2014-05-20
公開日2014-12-31
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.261 Å)
主引用文献Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum beta-Lactamases.
Biochemistry, 54, 2015
8SJ3
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Beta-lactamase CTX-M-14 E166Y/N170G
分子名称: Beta-lactamase CTX-M-14
著者Judge, A, Palzkill, T, Sankaran, B, Prasad, B.V.V, Hu, L.
登録日2023-04-17
公開日2024-02-21
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of CTX-M-14 E166Y/N170G at 1.5 Angstroms resolution
To Be Published
4PM8
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Crystal structure of CTX-M-14 S70G:S237A beta-lactamase at 1.17 Angstroms resolution
分子名称: Beta-lactamase CTX-M-14, SULFATE ION
著者Adamski, C.J, Cardenas, A.M, Sankaran, B, Palzkill, T.
登録日2014-05-20
公開日2014-12-31
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.169 Å)
主引用文献Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum beta-Lactamases.
Biochemistry, 54, 2015
4PMA
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Crystal structure of CTX-M-14 S70G:S237A:R276A beta-lactamase at 1.39 Angstroms resolution
分子名称: Beta-lactamase CTX-M-14, SULFATE ION
著者Cardenas, A.M, Adamski, C.J, Brown, N.G, Horton, L.B, Sankaran, B, Palzkill, T.
登録日2014-05-20
公開日2014-12-31
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.399 Å)
主引用文献Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum beta-Lactamases.
Biochemistry, 54, 2015
4PM9
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BU of 4pm9 by Molmil
Crystal structure of CTX-M-14 S70G:S237A:R276A beta-lactamase in complex with cefotaxime at 1.45 Angstroms resolution
分子名称: (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid, Beta-lactamase CTX-M-14
著者Cardenas, A.M, Adamski, C.J, Sankaran, B, Brown, N.G, Horton, L.B, Palzkill, T.
登録日2014-05-20
公開日2014-12-31
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.454 Å)
主引用文献Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum beta-Lactamases.
Biochemistry, 54, 2015
4PM7
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Crystal structure of CTX-M-14 S70G:S237A in complex with cefotaxime at 1.29 Angstroms resolution
分子名称: (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid, Beta-lactamase CTX-M-14
著者Adamski, C.J, Cardenas, A.M, Sankaran, B, Palzkill, T.
登録日2014-05-20
公開日2014-12-31
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum beta-Lactamases.
Biochemistry, 54, 2015
4PM6
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Crystal structure of CTX-M-14 S70G beta-lactamase at 1.56 Angstroms resolution
分子名称: Beta-lactamase CTX-M-14, SULFATE ION
著者Adamski, C.J, Cardenas, A.M, Sankaran, B, Palzkill, T.
登録日2014-05-20
公開日2014-12-31
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum beta-Lactamases.
Biochemistry, 54, 2015
4RVA
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A triple mutant in the omega-loop of TEM-1 beta-lactamase changes the substrate profile via a large conformational change and an altered general base for deacylation
分子名称: BICARBONATE ION, Beta-lactamase TEM
著者Stojanoski, V, Chow, D.-C, Hu, L, Sankaran, B, Gilbert, H, Prasad, B.V.V, Palzkill, T.
登録日2014-11-25
公開日2015-03-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4397 Å)
主引用文献A Triple Mutant in the Omega-loop of TEM-1 beta-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis.
J.Biol.Chem., 290, 2015
4RX3
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A triple mutant in the omega-loop of TEM-1 beta-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis
分子名称: Beta-lactamase TEM, CITRATE ANION
著者Stojanoski, V, Chow, D, Hu, L, Sankaran, B, Gilbert, H, Prasad, B.V.V, Palzkill, T.
登録日2014-12-08
公開日2015-03-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献A Triple Mutant in the Omega-loop of TEM-1 beta-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis.
J.Biol.Chem., 290, 2015
7JHQ
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BU of 7jhq by Molmil
OXA-48 bound by Compound 2.3
分子名称: 1,2-ETHANEDIOL, Beta-lactamase OXA-48, CHLORIDE ION, ...
著者Taylor, D.M, Hu, L, Prasad, B.V.V, Palzkill, T.
登録日2020-07-21
公開日2021-12-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48.
Acs Infect Dis., 7, 2021
7K5V
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OXA-48 bound by Compound 3.1
分子名称: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ...
著者Taylor, D.M, Hu, L, Prasad, B.V.V, Palzkill, T.
登録日2020-09-17
公開日2021-12-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48.
Acs Infect Dis., 7, 2021
7K2W
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Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase in complex with hydrolyzed cefotaxime
分子名称: Beta-lactamase, CEFOTAXIME, C3' cleaved, ...
著者Lu, S, Palzkill, T, Sankaran, B, Hu, L, Soeung, V, Prasad, B.V.V.
登録日2020-09-09
公開日2020-11-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A drug-resistant beta-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency.
J.Biol.Chem., 295, 2020
7K2Y
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Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase in complex with hydrolyzed ampicillin
分子名称: (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase
著者Lu, S, Palzkill, T, Sankaran, B, Hu, L, Soeung, V, Prasad, B.V.V.
登録日2020-09-09
公開日2020-11-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献A drug-resistant beta-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency.
J.Biol.Chem., 295, 2020
7K2X
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Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase
分子名称: Beta-lactamase, GLYCEROL
著者Lu, S, Palzkill, T, Sankaran, B, Hu, L, Soeung, V, Prasad, B.V.V.
登録日2020-09-09
公開日2020-11-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A drug-resistant beta-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency.
J.Biol.Chem., 295, 2020
7L8O
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OXA-48 bound by Compound 4.3
分子名称: 1,2-ETHANEDIOL, 9H-fluorene-2,7-disulfonate, Beta-lactamase, ...
著者Taylor, D.M, Hu, L, Prasad, B.V.V, Palzkill, T.
登録日2020-12-31
公開日2021-12-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48.
Acs Infect Dis., 7, 2021
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