7K2X
Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase
Summary for 7K2X
| Entry DOI | 10.2210/pdb7k2x/pdb |
| Descriptor | Beta-lactamase, GLYCEROL (3 entities in total) |
| Functional Keywords | antibiotic resistance, ctx-m-14, hydrolase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 8 |
| Total formula weight | 221393.44 |
| Authors | Lu, S.,Palzkill, T.,Sankaran, B.,Hu, L.,Soeung, V.,Prasad, B.V.V. (deposition date: 2020-09-09, release date: 2020-11-04, Last modification date: 2023-10-18) |
| Primary citation | Soeung, V.,Lu, S.,Hu, L.,Judge, A.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. A drug-resistant beta-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J.Biol.Chem., 295:18239-18255, 2020 Cited by PubMed: 33109613DOI: 10.1074/jbc.RA120.016103 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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