7K2X

Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030655	biological_process	beta-lactam antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0030655	biological_process	beta-lactam antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0030655	biological_process	beta-lactam antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0030655	biological_process	beta-lactam antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding
E	0008800	molecular_function	beta-lactamase activity
E	0016787	molecular_function	hydrolase activity
E	0017001	biological_process	antibiotic catabolic process
E	0030655	biological_process	beta-lactam antibiotic catabolic process
E	0046677	biological_process	response to antibiotic
E	0046872	molecular_function	metal ion binding
F	0008800	molecular_function	beta-lactamase activity
F	0016787	molecular_function	hydrolase activity
F	0017001	biological_process	antibiotic catabolic process
F	0030655	biological_process	beta-lactam antibiotic catabolic process
F	0046677	biological_process	response to antibiotic
F	0046872	molecular_function	metal ion binding
G	0008800	molecular_function	beta-lactamase activity
G	0016787	molecular_function	hydrolase activity
G	0017001	biological_process	antibiotic catabolic process
G	0030655	biological_process	beta-lactam antibiotic catabolic process
G	0046677	biological_process	response to antibiotic
G	0046872	molecular_function	metal ion binding
H	0008800	molecular_function	beta-lactamase activity
H	0016787	molecular_function	hydrolase activity
H	0017001	biological_process	antibiotic catabolic process
H	0030655	biological_process	beta-lactam antibiotic catabolic process
H	0046677	biological_process	response to antibiotic
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL A 301

Chain	Residue
A	THR202
A	ALA205
A	GLN206
A	THR209
A	HOH462
A	HOH518
C	TYR241
C	GLN270

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site_id	AC2
Number of Residues	7
Details	binding site for residue GOL B 301

Chain	Residue
B	ALA205
B	THR209
B	HOH436
B	HOH502
D	TYR241
D	GLN270
B	THR202

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site_id	AC3
Number of Residues	7
Details	binding site for residue GOL E 301

Chain	Residue
E	TYR241
E	GLN270
E	HOH413
E	HOH502
G	THR202
G	ALA205
G	THR209

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site_id	AC4
Number of Residues	7
Details	binding site for residue GOL F 301

Chain	Residue
F	TYR241
F	GLN270
F	HOH423
F	HOH503
H	THR202
H	GLN206
H	THR209

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Functional Information from PROSITE/UniProt

site_id	PS00146
Number of Residues	16
Details	BETA_LACTAMASE_A Beta-lactamase class-A active site. FpMCSTsKvmaAAAVL

Chain	Residue	Details
A	PHE66-LEU81

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