6P38
| Crystal Structure Analysis of TAF1 Bromodomain | 分子名称: | 4-{[(3R)-4-cyclopentyl-1,3-dimethyl-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl]amino}-N-(1-methylpiperidin-4-yl)-3-[(propan-2-yl)oxy]benzamide, Transcription initiation factor TFIID subunit 1 | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2019-05-23 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold. Acs Med.Chem.Lett., 10, 2019
|
|
6MBW
| Structure of Transcription Factor | 分子名称: | Signal transducer and activator of transcription 5B | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2018-08-30 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | Structural and functional consequences of the STAT5BN642H driver mutation. Nat Commun, 10, 2019
|
|
7KMR
| |
7SZC
| |
7SZD
| |
7SZB
| |
7SZA
| |
2QGX
| Ubiquitin-conjugating enzyme E2Q | 分子名称: | Ubiquitin-conjugating enzyme E2 Q1 | 著者 | Neculai, D, Avvakumov, G.V, Xue, S, Walker, J.R, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Sicheri, F, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-06-29 | 公開日 | 2008-03-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11, 2012
|
|
6P3A
| Crystal Structure Analysis of TAF1 Bromodomain | 分子名称: | 4-{[(3R)-1-(but-3-en-1-yl)-3-methyl-4-(oxan-4-yl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Transcription initiation factor TFIID subunit 1 | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2019-05-23 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Crystal Structure Analysis of TAF1 Bromodomain To Be Published
|
|
7TUO
| |
6P39
| Crystal Structure Analysis of TAF1 Bromodomain | 分子名称: | 3-methoxy-4-{[(6aR)-5-methyl-6-oxo-6,6a,7,8,9,10-hexahydro-5H-dipyrido[1,2-a:3',2'-e]pyrazin-2-yl]amino}-N-(1-methylpiperidin-4-yl)benzamide, Transcription initiation factor TFIID subunit 1 | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2019-05-23 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.941 Å) | 主引用文献 | Crystal Structure Analysis of TAF1 Bromodomain To Be Published
|
|
3N3K
| The catalytic domain of USP8 in complex with a USP8 specific inhibitor | 分子名称: | Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 8, ZINC ION | 著者 | Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Allali-Hassani, A, Lam, R, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | 登録日 | 2010-05-20 | 公開日 | 2010-06-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A strategy for modulation of enzymes in the ubiquitin system. Science, 339, 2013
|
|
1QQG
| |
7TUN
| |
7U5W
| |
7U5X
| |
1Q2H
| Phenylalanine Zipper Mediates APS Dimerization | 分子名称: | adaptor protein with pleckstrin homology and src homology 2 domains | 著者 | Dhe-Paganon, S, Werner, E.D, Nishi, M, Chi, Y.-I, Shoelson, S.E. | 登録日 | 2003-07-24 | 公開日 | 2004-08-03 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A phenylalanine zipper mediates APS dimerization. Nat.Struct.Mol.Biol., 11, 2004
|
|
6O34
| |
6O33
| |
2R2Q
| Crystal structure of human Gamma-Aminobutyric Acid Receptor-Associated Protein-like 1 (GABARAP1), Isoform CRA_a | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Gamma-aminobutyric acid receptor-associated protein-like 1, UNKNOWN ATOM OR ION | 著者 | Tempel, W, Paramanathan, R, Davis, T, Mujib, S, Butler-Cole, C, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2007-08-27 | 公開日 | 2007-09-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structure of human Gamma-Aminobutyric Acid Receptor-Associated Protein-like 1 (GABARAP1), Isoform CRA_a. To be Published
|
|
1IFR
| |
7S7G
| Crystal Structure Analysis of Human VLCAD | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | 著者 | Seo, H.-S, Dhe-Paganon, S. | 登録日 | 2021-09-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun, 13, 2022
|
|
1IC8
| HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT | 分子名称: | 5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3', HEPATOCYTE NUCLEAR FACTOR 1-ALPHA | 著者 | Chi, Y.-I, Frantz, J.D, Oh, B.-C, Hansen, L, Dhe-Paganon, S, Shoelson, S.E. | 登録日 | 2001-03-30 | 公開日 | 2002-11-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Diabetes mutations delineate an
atypical POU domains in HNF1-Alpha Mol.Cell, 10, 2002
|
|
1M7W
| HNF4a ligand binding domain with bound fatty acid | 分子名称: | Hepatocyte nuclear factor 4-alpha, LAURIC ACID | 著者 | Dhe-Paganon, S, Duda, K, Iwamoto, M, Chi, Y.I, Shoelson, S.E. | 登録日 | 2002-07-22 | 公開日 | 2003-07-01 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand J.Biol.Chem., 277, 2002
|
|
2QFE
| Distal C2-Like Domain of Human Calpain-7 | 分子名称: | BROMIDE ION, Calpain-7 | 著者 | Walker, J.R, Cuerrier, D, Ravulapalli, R, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S. | 登録日 | 2007-06-27 | 公開日 | 2007-07-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure of the C2 Domain of Human Calpain-7 To be Published
|
|