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PDB: 66 results

8C25
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BU of 8c25 by Molmil
purine nucleoside phosphorylase in complex with JS-375
Descriptor: CHLORIDE ION, GLYCEROL, Purine nucleoside phosphorylase, ...
Authors:Djukic, S, Pachl, P, Rezacova, P.
Deposit date:2022-12-21
Release date:2023-05-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
J.Med.Chem., 66, 2023
6YI7
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BU of 6yi7 by Molmil
Structure of cathepsin B1 from Schistosoma mansoni (SmCB1) in complex with an azanitrile inhibitor
Descriptor: 1-[(2~{S})-1-[[iminomethyl(methyl)amino]-methyl-amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-3-(phenylmethyl)urea, ACETATE ION, Cathepsin B-like peptidase (C01 family)
Authors:Jilkova, A, Rezacova, P, Pachl, P, Fanfrlik, J, Rubesova, P, Guetschow, M, Mares, M.
Deposit date:2020-04-01
Release date:2020-12-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni : Structural and Mechanistic Insights into Chemotype Reactivity.
Acs Infect Dis., 7, 2021
4NGS
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BU of 4ngs by Molmil
Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Tykvart, J, Pachl, P.
Deposit date:2013-11-02
Release date:2014-06-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.
Bioorg.Med.Chem., 22, 2014
4NGR
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BU of 4ngr by Molmil
Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Tykvart, J, Pachl, P.
Deposit date:2013-11-02
Release date:2014-06-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.
Bioorg.Med.Chem., 22, 2014
4NGM
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BU of 4ngm by Molmil
Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Tykvart, J, Pachl, P.
Deposit date:2013-11-02
Release date:2014-06-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.
Bioorg.Med.Chem., 22, 2014
4NGT
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BU of 4ngt by Molmil
Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Tykvart, J, Pachl, P.
Deposit date:2013-11-02
Release date:2014-06-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.
Bioorg.Med.Chem., 22, 2014
5OPK
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BU of 5opk by Molmil
Crystal structure of D52N/R367Q cN-II mutant bound to dATP and free phosphate
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, GLYCEROL, ...
Authors:Hnizda, A, Pachl, P, Rezacova, P.
Deposit date:2017-08-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
5OPP
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BU of 5opp by Molmil
Crystal structure of S408R cN-II mutant
Descriptor: BROMIDE ION, Cytosolic purine 5'-nucleotidase, GLYCEROL, ...
Authors:Hnizda, A, Pachl, P, Rezacova, P.
Deposit date:2017-08-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
5OPN
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BU of 5opn by Molmil
Crystal structure of R39Q cN-II mutant
Descriptor: Cytosolic purine 5'-nucleotidase, GLYCEROL
Authors:Hnizda, A, Pachl, P, Rezacova, P.
Deposit date:2017-08-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
5OPO
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BU of 5opo by Molmil
Crystal structure of R238G cN-II mutant
Descriptor: Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION
Authors:Hnizda, A, Pachl, P, Rezacova, P.
Deposit date:2017-08-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Leukemia, 32, 2018
7ACK
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BU of 7ack by Molmil
CDK2/cyclin A2 in complex with an imidazo[1,2-c]pyrimidin-5-one inhibitor
Descriptor: 1,2-ETHANEDIOL, 8-cyclohexyl-6~{H}-imidazo[1,2-c]pyrimidin-5-one, Cyclin-A2, ...
Authors:Skerlova, J, Pachl, P, Rezacova, P.
Deposit date:2020-09-11
Release date:2021-03-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure.
Eur.J.Med.Chem., 216, 2021
5K7Y
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BU of 5k7y by Molmil
Crystal structure of enzyme in purine metabolism
Descriptor: Cytosolic purine 5'-nucleotidase, GLYCEROL
Authors:Skerlova, J, Hnizda, A, Pachl, P, Rezacova, P.
Deposit date:2016-05-27
Release date:2016-09-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia.
Bmc Biol., 14, 2016
5L4Z
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BU of 5l4z by Molmil
Crystal structure of enzyme in purine metabolism
Descriptor: Cytosolic purine 5'-nucleotidase, GLYCEROL
Authors:Hnizda, A, Pachl, P, Rezacova, P.
Deposit date:2016-05-27
Release date:2016-09-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia.
Bmc Biol., 14, 2016
5L50
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BU of 5l50 by Molmil
Crystal structure of enzyme in purine metabolism
Descriptor: Cytosolic purine 5'-nucleotidase, GLYCEROL
Authors:Hnizda, A, Pachl, P, Rezacova, P.
Deposit date:2016-05-27
Release date:2016-09-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.643 Å)
Cite:Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia.
Bmc Biol., 14, 2016
6SYI
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BU of 6syi by Molmil
C-TERMINAL DOMAIN OF INFLUENZA POLYMERASE PA SUBUNIT AND OPTIMIZED SMALL PEPTIDE INHIBITOR
Descriptor: 1,2-ETHANEDIOL, PB1-11, Polymerase acidic protein, ...
Authors:Hejdanek, J, Pachl, P.
Deposit date:2019-09-30
Release date:2020-11-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor.
Antiviral Res., 185, 2020
6IAH
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BU of 6iah by Molmil
Phosphatase Tt82 from Thermococcus thioreducens
Descriptor: CHLORIDE ION, Hydrolase, MAGNESIUM ION
Authors:Havlickova, P, Brinsa, V, Brynda, J, Pachl, P, Prudnikova, T, Mesters, J.R, Kascakova, B, Kuty, M, Pusey, M.L, Ng, J.D, Rezacova, P, Smatanova, I.K.
Deposit date:2018-11-26
Release date:2019-08-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A novel structurally characterized haloacid dehalogenase superfamily phosphatase from Thermococcus thioreducens with diverse substrate specificity.
Acta Crystallogr D Struct Biol, 75, 2019
5I67
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BU of 5i67 by Molmil
Crystal Structure Analysis of MTB PEPCK mutant C273S
Descriptor: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Dostal, J, Pachl, P, Machova, I, Pichova, I, Snasel, J.
Deposit date:2016-02-16
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Crystal Structure Analysis of MTB PEPCK mutant C273S
To Be Published
5F09
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BU of 5f09 by Molmil
Structure of inactive GCPII mutant in complex with beta-citryl glutamate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Tykvart, J, Navratil, M, Pachl, P, Konvalinka, J.
Deposit date:2015-11-27
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Comparison of human glutamate carboxypeptidases II and III reveals their divergent substrate specificities.
Febs J., 283, 2016
6I1M
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BU of 6i1m by Molmil
Secreted type 1 cystatin from Fasciola hepatica
Descriptor: Cystatin, IODIDE ION
Authors:Busa, M, Rezacova, P, Pachl, P, Stefanic, S, Mares, M.
Deposit date:2018-10-29
Release date:2020-08-26
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily.
J.Biol.Chem., 299, 2023
4NGN
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BU of 4ngn by Molmil
Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Tykvart, J, Pachl, P.
Deposit date:2013-11-02
Release date:2014-06-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.
Bioorg.Med.Chem., 22, 2014
4NGQ
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BU of 4ngq by Molmil
Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Tykvart, J, Pachl, P.
Deposit date:2013-11-02
Release date:2014-06-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.
Bioorg.Med.Chem., 22, 2014
4NGP
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BU of 4ngp by Molmil
Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Tykvart, J, Pachl, P.
Deposit date:2013-11-02
Release date:2014-06-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.
Bioorg.Med.Chem., 22, 2014
7KB0
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BU of 7kb0 by Molmil
O-acety-L-homoserine aminocarboxypropyltransferase (MetY) from Thermotoga maritima with pyridoxal-5-phosphate (PLP) bound in the internal aldimine state
Descriptor: O-acetyl-L-homoserine sulfhydrylase
Authors:Brewster, J.L, Pachl, P, Squire, C, Selmer, M, Patrick, W.M.
Deposit date:2020-10-01
Release date:2021-06-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis.
J.Biol.Chem., 296, 2021
7KB1
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BU of 7kb1 by Molmil
Complex of O-acety-L-homoserine aminocarboxypropyltransferase (MetY) from Thermotoga maritima and a key reaction intermediate
Descriptor: (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid, MAGNESIUM ION, O-acetyl-L-homoserine sulfhydrylase, ...
Authors:Brewster, J.L, Pachl, P, Squire, C, Selmer, M, Patrick, W.M.
Deposit date:2020-10-01
Release date:2021-06-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis.
J.Biol.Chem., 296, 2021
7ZSM
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BU of 7zsm by Molmil
human purine nucleoside phosphorylase in complex with JS-375
Descriptor: CHLORIDE ION, Purine nucleoside phosphorylase, SULFATE ION, ...
Authors:Djukic, S, Pachl, P, Rezacova, P.
Deposit date:2022-05-07
Release date:2023-05-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
J.Med.Chem., 66, 2023

221051

数据于2024-06-12公开中

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