7ZSQ

human purine nucleoside phosphorylase in complex with JS-555

Summary for 7ZSQ

• Entry DOI: 10.2210/pdb7zsq/pdb
• Descriptor: Purine nucleoside phosphorylase, [2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenoxy]methylphosphonic acid, 6-tungstotellurate(VI), ... (8 entities in total)
• Functional Keywords: pnp-inhibitor complex, transferase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 3
• Total formula weight: 86771.33

Authors

Djukic, S.,Pachl, P.,Rezacova, P. (deposition date: 2022-05-08, release date: 2023-05-17, Last modification date: 2024-02-07)

• Primary citation: Skacel, J.,Djukic, S.,Baszczynski, O.,Kalcic, F.,Bilek, T.,Chalupsky, K.,Kozak, J.,Dvorakova, A.,Tloust'ova, E.,Kral'ova, Z.,Smidkova, M.,Voldrich, J.,Rumlova, M.,Pachl, P.,Brynda, J.,Vuckova, T.,Fabry, M.,Snasel, J.,Pichova, I.,Rezacova, P.,Mertlikova-Kaiserova, H.,Janeba, Z.; Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.; J.Med.Chem., 66:6652-6681, 2023; PubMed: 37134237; DOI: 10.1021/acs.jmedchem.2c02097

Experimental method

X-RAY DIFFRACTION (1.77 Å)