6FFW
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![BU of 6ffw by Molmil](/molmil-images/mine/6ffw) | Phosphotriesterase PTE_A53_5 | Descriptor: | (4~{S},6~{R})-2,2,6-trimethyl-1,3-dioxan-4-ol, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Dym, O, Aggarwal, N, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Leader, H, Ashani, Y, Goldsmith, M, Greisen, P, Tawfik, D, Sussman, L.J. | Deposit date: | 2018-01-09 | Release date: | 2019-03-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.495 Å) | Cite: | Phosphotriesterase
PTE_A53_5 To Be Published
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6QF7
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![BU of 6qf7 by Molmil](/molmil-images/mine/6qf7) | Crystal structures of the recombinant beta-Factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XII, ... | Authors: | Pathak, M, Mannal, R, Li, C, Bubacarr, G.K, Badraldin, K.H, Belviso, B.D, Camila, R.B, Dreveny, I, Fischer, P.M, Dekker, L.V, Oliva, M.L.V, Emsley, J. | Deposit date: | 2019-01-09 | Release date: | 2019-06-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystal structures of the recombinant beta-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics. Acta Crystallogr D Struct Biol, 75, 2019
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6FJF
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![BU of 6fjf by Molmil](/molmil-images/mine/6fjf) | Tubulin-FcMaytansine complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Menchon, G, Prota, A.E, Lucena Angell, D, Bucher, P, Mueller, R, Paterson, I, Diaz, J.F, Altmann, K.-H, Steinmetz, M.O. | Deposit date: | 2018-01-22 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin. Nat Commun, 9, 2018
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4BSA
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![BU of 4bsa by Molmil](/molmil-images/mine/4bsa) | Crystal Structure of the Haemagglutinin (with Asn-133 Glycosylation) from an H7N9 Influenza Virus Isolated from Humans | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, ... | Authors: | Xiong, X, Haire, L.F, Martin, S.R, Wharton, S.A, Daniels, R.S, Bennett, M.S, McCauley, J.W, Collins, P.J, Walker, P.A, Skehel, J.J, Gamblin, S.J. | Deposit date: | 2013-06-10 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Receptor Binding by an H7N9 Influenza Virus from Humans Nature, 499, 2013
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6PTL
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![BU of 6ptl by Molmil](/molmil-images/mine/6ptl) | |
1I6L
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![BU of 1i6l by Molmil](/molmil-images/mine/1i6l) | |
6STV
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![BU of 6stv by Molmil](/molmil-images/mine/6stv) | Adenovirus 29 Fiber Knob protein | Descriptor: | Fiber, GLYCEROL, PHOSPHATE ION | Authors: | Mundy, R.M, Baker, A.T, Rizkallah, P.J, Parker, A.L. | Deposit date: | 2019-09-11 | Release date: | 2021-03-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Broad sialic acid usage amongst species D human adenovirus npj Viruses, 1, 2023
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4BTI
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![BU of 4bti by Molmil](/molmil-images/mine/4bti) | factor Xa in complex with the dual thrombin-FXa inhibitor 58. | Descriptor: | 5-Chloro-thiophene-2-carboxylic acid [(S)-2-[2-difluoromethoxy-3-(2-oxo-piperidin-1-yl)-benzenesulfonylamino]-3-((S)-3-dimethylamino-pyrrolidin-1-yl)-3-oxo-propyl]-amide, CALCIUM ION, COAGULATION FACTOR X HEAVY CHAIN, ... | Authors: | Meneyrol, J, Follmann, M, Lassalle, G, Wehner, V, Barre, G, Rousseaux, T, Altenburger, J.M, Petit, F, Bocskei, Z, Stehlin-Gaon, C, Schreuder, H, Alet, N, Herault, J.-P, Millet, L, Dol, F, Hasbrand, C, Schaeffer, P, Sadoun, F, Klieber, S, Briot, C, Bono, F, Herbert, J.-M. | Deposit date: | 2013-06-18 | Release date: | 2013-12-25 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | 5-Chlorothiophene-2-Carboxylic Acid [(S)-2-[2-Methyl-3-(2-Oxopyrrolidin-1-Yl)Benzenesulfonylamino]-3-(4-Methylpiperazin-1-Yl)-3-Oxopropyl]Amide (Sar107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor. J.Med.Chem., 56, 2013
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6VAX
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![BU of 6vax by Molmil](/molmil-images/mine/6vax) | Crystal structure of human SDHA-SDHAF2 assembly intermediate | Descriptor: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Sharma, P, Maklashina, E, Cecchini, G, Iverson, T.M. | Deposit date: | 2019-12-18 | Release date: | 2020-08-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein. Proc.Natl.Acad.Sci.USA, 117, 2020
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2JLW
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![BU of 2jlw by Molmil](/molmil-images/mine/2jlw) | Dengue virus 4 NS3 helicase in complex with ssRNA2 | Descriptor: | 5'-R(*UP*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', GLYCEROL, PHOSPHATE ION, ... | Authors: | Luo, D.H, Xu, T, Watson, R.P, Becker, D.S, Sampath, A, Jahnke, W, Yeong, S.S, Wang, C.H, Lim, S.P, Vasudevan, S.G, Lescar, J. | Deposit date: | 2008-09-15 | Release date: | 2008-11-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein Embo J., 27, 2008
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6Q0X
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2JCM
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![BU of 2jcm by Molmil](/molmil-images/mine/2jcm) | Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with beryllium trifluoride | Descriptor: | CYTOSOLIC PURINE 5'-NUCLEOTIDASE, MAGNESIUM ION, SULFATE ION, ... | Authors: | Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P. | Deposit date: | 2006-12-27 | Release date: | 2007-01-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition J.Biol.Chem., 282, 2007
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2JC3
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![BU of 2jc3 by Molmil](/molmil-images/mine/2jc3) | Structure of O-Acetylserine Sulfhydrylase B from Salmonella Typhimurium | Descriptor: | O-ACETYLSERINE SULFHYDRYLASE B, PYRIDOXAL-5'-PHOSPHATE | Authors: | Chattopadhyay, A, Rabeh, W.M, Speroni, F, Meier, M, Ivaninskii, S, Mozzarelli, A, Burkhard, P, Cook, P.F. | Deposit date: | 2006-12-19 | Release date: | 2007-01-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure, Mechanism, and Conformational Dynamics of O-Acetylserine Sulfhydrylase from Salmonella Typhimurium: Comparison of a and B Isozymes. Biochemistry, 46, 2007
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8HYL
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![BU of 8hyl by Molmil](/molmil-images/mine/8hyl) | Crystal structure of DO1 Fv-clasp fragment | Descriptor: | VH-SARAH, VL-SARAH | Authors: | Anan, Y, Lu, P, Nagata, K, Itakura, M, Uchida, K. | Deposit date: | 2023-01-06 | Release date: | 2024-02-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular and structural basis of anti-DNA antibody specificity for pyrrolated proteins. Commun Biol, 7, 2024
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4BQP
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![BU of 4bqp by Molmil](/molmil-images/mine/4bqp) | Mtb InhA complex with Methyl-thiazole compound 7 | Descriptor: | (1S)-1-(5-{[1-(2,6-DIFLUOROBENZYL)-1H-PYRAZOL-3-YL]AMINO}-1,3,4-THIADIAZOL-2-YL)-1-(4-METHYL-1,3-THIAZOL-2-YL)ETHANOL, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Read, J.A, Gingell, H, Madhavapeddi, P, Shirude, P.S. | Deposit date: | 2013-05-31 | Release date: | 2013-12-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting Inha in Mycobacterium Tuberculosis. J.Med.Chem., 56, 2013
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7A3Z
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![BU of 7a3z by Molmil](/molmil-images/mine/7a3z) | OSM-3 kinesin motor domain complexed with Mg.ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Osmotic avoidance abnormal protein 3 | Authors: | Varela, F.P, Menetrey, J, Gigant, B. | Deposit date: | 2020-08-19 | Release date: | 2021-02-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.095 Å) | Cite: | Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism. Febs Open Bio, 11, 2021
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6Q0B
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![BU of 6q0b by Molmil](/molmil-images/mine/6q0b) | Poliovirus (Type 1 Mahoney), receptor-catalysed 135S particle incubated with anti-VP1 mAb at RT for 1 hr | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | Authors: | Hogle, J.M, Filman, D.J, Shah, P.N.M. | Deposit date: | 2019-08-01 | Release date: | 2020-08-05 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate. Plos Pathog., 16, 2020
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2PCV
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![BU of 2pcv by Molmil](/molmil-images/mine/2pcv) | |
7A5R
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![BU of 7a5r by Molmil](/molmil-images/mine/7a5r) | Complex of SARS-CoV-2 spike and CR3022 Fab (Non-Uniform Refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 Fab Heavy Chain, CR3022 Fab Light Chain, ... | Authors: | Wrobel, A.G, Benton, D.J, Rosenthal, P.B, Gamblin, S.J. | Deposit date: | 2020-08-21 | Release date: | 2020-09-16 | Last modified: | 2020-11-04 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein. Nat Commun, 11, 2020
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6SSO
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![BU of 6sso by Molmil](/molmil-images/mine/6sso) | EDN mutant L45H | Descriptor: | ACETATE ION, Non-secretory ribonuclease | Authors: | Fernandez-Millan, P, Prats-Ejarque, G, Vazquez-Monteagudo, S, Boix, E. | Deposit date: | 2019-09-08 | Release date: | 2021-10-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.211 Å) | Cite: | Structural and functional characterization of new family enzymes derivates from human RNase 1 and 3 with antimicrobial and ribonuclease activity To Be Published
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4BSH
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![BU of 4bsh by Molmil](/molmil-images/mine/4bsh) | H7N3 Avian Influenza Virus Haemagglutinin in Complex with Human Receptor Analogue 6'-SLN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, ... | Authors: | Xiong, X, Haire, L.F, Martin, S.R, Wharton, S.A, Daniels, R.S, Bennett, M.S, McCauley, J.W, Collins, P.J, Walker, P.A, Skehel, J.J, Gamblin, S.J. | Deposit date: | 2013-06-10 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Receptor Binding by an H7N9 Influenza Virus from Humans Nature, 499, 2013
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7A6U
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![BU of 7a6u by Molmil](/molmil-images/mine/7a6u) | Cryo-EM structure of the cytoplasmic domain of human TRPC6 | Descriptor: | Short transient receptor potential channel 6, UNKNOWN ATOM OR ION | Authors: | Grieben, M, Pike, A.C.W, Wang, D, Mukhopadhyay, S.M.M, Chalk, R, Marsden, B.D, Burgess-Brown, N.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2020-08-26 | Release date: | 2020-09-30 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Cryo-EM structure of the cytoplasmic domain of human TRPC6 TO BE PUBLISHED
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6FRC
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![BU of 6frc by Molmil](/molmil-images/mine/6frc) | |
4C6S
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![BU of 4c6s by Molmil](/molmil-images/mine/4c6s) | Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RRS1 | Descriptor: | GLYCEROL, PROBABLE WRKY TRANSCRIPTION FACTOR 52, SODIUM ION, ... | Authors: | Wan, L, Williams, S.J, Sohn, K.H, Bernoux, M, Ma, Y, Segonzac, C, Ve, T, Sarris, P, Ericsson, D.J, Saucet, S.B, Zhang, X, Parker, J, Dodds, P.N, Jones, J.D.G, Kobe, B. | Deposit date: | 2013-09-19 | Release date: | 2014-05-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor. Science, 344, 2014
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7INS
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![BU of 7ins by Molmil](/molmil-images/mine/7ins) | STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z | Descriptor: | GENERAL PROTAMINE CHAIN, INSULIN (CHAIN A), INSULIN (CHAIN B), ... | Authors: | Balschmidt, P, Hansen, F.B, Dodson, E, Dodson, G, Korber, F. | Deposit date: | 1991-09-03 | Release date: | 1994-01-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of porcine insulin cocrystallized with clupeine Z. Acta Crystallogr.,Sect.B, 47, 1991
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