7A5R

Complex of SARS-CoV-2 spike and CR3022 Fab (Non-Uniform Refinement)

Summary for 7A5R

• Entry DOI: 10.2210/pdb7a5r/pdb
• EMDB information: 11648
• Descriptor: CR3022 Fab Heavy Chain, CR3022 Fab Light Chain, Spike glycoprotein, ... (4 entities in total)
• Functional Keywords: sars-cov-2, antibody, viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 393233.51

Authors

Wrobel, A.G.,Benton, D.J.,Rosenthal, P.B.,Gamblin, S.J. (deposition date: 2020-08-21, release date: 2020-09-16, Last modification date: 2024-11-20)

Primary citation

Wrobel, A.G.,Benton, D.J.,Hussain, S.,Harvey, R.,Martin, S.R.,Roustan, C.,Rosenthal, P.B.,Skehel, J.J.,Gamblin, S.J.
Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.
Nat Commun, 11:5337-5337, 2020

PubMed Abstract: The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.

PubMed: 33087721
DOI: 10.1038/s41467-020-19146-5

Experimental method

ELECTRON MICROSCOPY (3.7 Å)