7M7I
 
 | | 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2 (TE-free) | | Descriptor: | 1B2 (heavy chain), 1B2 (light chain), EryAI, ... | | Authors: | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | | Deposit date: | 2021-03-28 | | Release date: | 2021-11-17 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
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7M7F
 | | 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1 | | Descriptor: | 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ... | | Authors: | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | | Deposit date: | 2021-03-28 | | Release date: | 2021-11-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
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1GU9
 | | Crystal Structure of Mycobacterium tuberculosis Alkylperoxidase AhpD | | Descriptor: | ALKYLHYDROPEROXIDASE D | | Authors: | Nunn, C.M, Djordjevic, S, Hillas, P.J, Nishida, C, Ortiz de Montellano, P.R. | | Deposit date: | 2002-01-24 | | Release date: | 2002-02-14 | | Last modified: | 2018-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Crystal Structure of Mycobacterium Tuberculosis Alkylhydroperoxidase Ahpd, a Potential Target for Antitubercular Drug Design
J.Biol.Chem., 277, 2002
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1GUW
 | | STRUCTURE OF THE CHROMODOMAIN FROM MOUSE HP1beta IN COMPLEX WITH THE LYSINE 9-METHYL HISTONE H3 N-TERMINAL PEPTIDE, NMR, 25 STRUCTURES | | Descriptor: | CHROMOBOX PROTEIN HOMOLOG 1, HISTONE H3.1 | | Authors: | Nielsen, P.R, Nietlispach, D, Mott, H.R, Callaghan, J.M, Bannister, A, Kouzarides, T, Murzin, A.G, Murzina, N.V, Laue, E.D. | | Deposit date: | 2002-02-01 | | Release date: | 2002-03-12 | | Last modified: | 2018-01-17 | | Method: | SOLUTION NMR | | Cite: | Structure of the Hp1 Chromodomain Bound to Histone H3 Methylated at Lysine 9
Nature, 416, 2002
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1TC8
 | | Crystal structure of Krait-venom phospholipase A2 in a complex with a natural fatty acid tridecanoic acid | | Descriptor: | N-TRIDECANOIC ACID, SODIUM ION, phospholipase A2 isoform 1 | | Authors: | Singh, G, Jasti, J, Saravanan, K, Sharma, S, Kaur, P, Srinivasan, A, Singh, T.P. | | Deposit date: | 2004-05-21 | | Release date: | 2004-06-08 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the complex formed between a group I phospholipase A2 and a naturally occurring fatty acid at 2.7 A resolution
PROTEIN SCI., 14, 2005
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4C1N
 | | Corrinoid protein reactivation complex with activator | | Descriptor: | CARBON MONOXIDE DEHYDROGENASE CORRINOID/IRON-SULFUR PROTEIN, GAMMA SUBUNIT, CO DEHYDROGENASE/ACETYL-COA SYNTHASE, ... | | Authors: | Hennig, S.E, Goetzl, S, Jeoung, J.H, Bommer, M, Lendzian, F, Hildebrandt, P, Dobbek, H. | | Deposit date: | 2013-08-13 | | Release date: | 2014-08-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | ATP-Induced Electron Transfer by Redox-Selective Partner Recognition
Nat.Commun., 5, 2014
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1XIY
 | | Crystal Structure of Plasmodium falciparum antioxidant protein (1-Cys peroxiredoxin) | | Descriptor: | peroxiredoxin | | Authors: | Sarma, G.N, Fischer, M, Nickel, C, Becker, K, Karplus, P.A. | | Deposit date: | 2004-09-22 | | Release date: | 2005-02-15 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin.
J.Mol.Biol., 346, 2005
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1TFV
 | | CRYSTAL STRUCTURE OF A BUFFALO SIGNALING GLYCOPROTEIN (SPB-40) SECRETED DURING INVOLUTION | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, mammary gland protein 40 | | Authors: | Bilgrami, S, Saravanan, K, Yadav, S, Kaur, P, Srinivasan, A, Singh, T.P. | | Deposit date: | 2004-05-27 | | Release date: | 2004-07-13 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | CRYSTAL STRUCTURE OF A BUFFALO SIGNALING GLYCOPROTEIN (SPB-40)
SECRETED DURING INVOLUTION
To be Published
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4TN8
 | | Crystal structure of Thermus Thermophilus thioredoxin solved by sulfur SAD using Swiss Light Source data | | Descriptor: | CHLORIDE ION, Thioredoxin | | Authors: | Weinert, T, Waltersperger, S, Olieric, V, Panepucci, E, Chen, L, Rose, J.P, Wang, M, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2014-06-03 | | Release date: | 2014-12-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
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1L9Y
 | | FEZ-1-Y228A, A Mutant of the Metallo-beta-lactamase from Legionella gormanii | | Descriptor: | CHLORIDE ION, FEZ-1 b-lactamase, GLYCEROL, ... | | Authors: | Garcia-Saez, I, Mercuri, P.S, Galleni, M, Dideberg, O. | | Deposit date: | 2002-03-27 | | Release date: | 2003-07-01 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Three-dimensional Structure of FEZ-1, a Monomeric Subclass B3 Metallo-beta-lactamase
from Fluoribacter gormanii, in Native Form and in Complex with -Captopril
J.Mol.Biol., 325, 2003
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1QAN
 | | THE STRUCTURE OF THE RRNA METHYLTRANSFERASE ERMC': IMPLICATIONS FOR THE REACTION MECHANISM | | Descriptor: | ACETATE ION, ERMC' METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Schluckebier, G, Zhong, P, Stewart, K.D, Kavanaugh, T.J, Abad-Zapatero, C. | | Deposit date: | 1999-03-26 | | Release date: | 2000-03-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.
J.Mol.Biol., 289, 1999
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7M74
 | | ATP-bound AMP-activated protein kinase | | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | | Authors: | Yan, Y, Mukherjee, S, Harikumar, K.G, Strutzenberg, T, Zhou, X.E, Powell, S.K, Xu, T, Sheldon, R, Lamp, J, Brunzelle, J.S, Radziwon, K, Ellis, A, Novick, S.J, Vega, I.E, Jones, R, Miller, L.J, Xu, H.E, Griffin, P.R, Kossiakoff, A.A, Melcher, K. | | Deposit date: | 2021-03-26 | | Release date: | 2021-12-15 | | Last modified: | 2021-12-22 | | Method: | ELECTRON MICROSCOPY (3.93 Å) | | Cite: | Structure of an AMPK complex in an inactive, ATP-bound state.
Science, 373, 2021
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4BV6
 | | Refined crystal structure of the human Apoptosis inducing factor | | Descriptor: | APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Martinez-Julvez, M, Herguedas, B, Hermoso, J.A, Ferreira, P, Villanueva, R, Medina, M. | | Deposit date: | 2013-06-25 | | Release date: | 2014-09-17 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Insights Into the Coenzyme Mediated Monomer-Dimer Transition of the Pro-Apoptotic Apoptosis Inducing Factor.
Biochemistry, 53, 2014
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1XFA
 | | Structure of NBD1 from murine CFTR- F508R mutant | | Descriptor: | ACETIC ACID, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | | Authors: | Thibodeau, P.H, Brautigam, C.A, Machius, M, Thomas, P.J. | | Deposit date: | 2004-09-14 | | Release date: | 2004-12-28 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Side chain and backbone contributions of Phe508 to CFTR folding.
Nat.Struct.Mol.Biol., 12, 2005
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1GS4
 | | Structural basis for the glucocorticoid response in a mutant human androgen receptor (ARccr) derived from an androgen-independent prostate cancer | | Descriptor: | 9ALPHA-FLUOROCORTISOL, ANDROGEN RECEPTOR, PHOSPHATE ION | | Authors: | Matias, P.M, Carrondo, M.A, Coelho, R, Thomaz, M, Zhao, X.-Y, Wegg, A, Crusius, K, Egner, U, Donner, P. | | Deposit date: | 2001-12-27 | | Release date: | 2003-01-16 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural Basis for the Glucocorticoid Response in a Mutant Human Androgen Receptor (Ar(Ccr)) Derived from an Androgen-Independent Prostate Cancer
J.Med.Chem., 45, 2002
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1TBC
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4BL4
 | | Further structural insights into the binding of complement factor H by complement regulator acquiring surface protein 1, CspA (BbCRASP-1), of Borrelia burgdorferi. | | Descriptor: | COMPLEMENT REGULATOR-ACQUIRING SURFACE PROTEIN 1 (CRASP-1) | | Authors: | Caesar, J.J.E, Wallich, R, Kraiczy, P, Zipfel, P.F, Lea, S.M. | | Deposit date: | 2013-05-01 | | Release date: | 2013-06-05 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (4.06 Å) | | Cite: | Further Structural Insights Into the Binding of Complement Factor H by Complement Regulator-Acquiring Surface Protein 1 (CspA) of Borrelia Burgdorferi.
Acta Crystallogr.,Sect.F, 69, 2013
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2Q1C
 | | 2-keto-3-deoxy-D-arabinonate dehydratase complexed with calcium and 2-oxobutyrate | | Descriptor: | 2-KETOBUTYRIC ACID, 2-keto-3-deoxy-D-arabinonate dehydratase, CALCIUM ION | | Authors: | Barends, T, Brouns, S, Worm, P, Akerboom, J, Turnbull, A, Salmon, L. | | Deposit date: | 2007-05-24 | | Release date: | 2008-04-08 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural insight into substrate binding and catalysis of a novel 2-keto-3-deoxy-D-arabinonate dehydratase illustrates common mechanistic features of the FAH superfamily.
J.Mol.Biol., 379, 2008
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1HL4
 | | The Structure of Apo Type Human Cu, Zn Superoxide Dismutase | | Descriptor: | SUPEROXIDE DISMUTASE, ZINC ION | | Authors: | Strange, R.W, Antonyuk, S, Hough, M.A, Doucette, P, Rodriguez, J, Hart, P.J, Hayward, L.J, Valentine, J.S, Hasnain, S.S. | | Deposit date: | 2003-03-13 | | Release date: | 2003-05-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | The Structure of Holo and Metal-Deficient Wild-Type Human Cu, Zn Superoxide Dismutase and its Relevance to Familial Amyotrophic Lateral Sclerosis
J.Mol.Biol., 328, 2003
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1HK8
 | | STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DGTP | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE, MANGANESE (II) ION, ... | | Authors: | Larsson, K.-M, Andersson, J, Sjoeberg, B.-M, Nordlund, P, Logan, D.T. | | Deposit date: | 2003-03-06 | | Release date: | 2003-03-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | A Metal-Binding Site in the Catalytic Subunit of Anaerobic Ribonucleotide Reductase.
Proc.Natl.Acad.Sci.USA, 100, 2003
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2JPJ
 | | Lactococcin G-a in DPC | | Descriptor: | Bacteriocin lactococcin-G subunit alpha | | Authors: | Rogne, P, Fimland, G, Nissen-Meyer, J, Kristiansen, P.E. | | Deposit date: | 2007-05-15 | | Release date: | 2008-02-19 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional structure of the two peptides that constitute the two-peptide bacteriocin lactococcin G
Biochim.Biophys.Acta, 1784, 2008
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4FXF
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4LUK
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3QK0
 | | Crystal structure of PI3K-gamma in complex with benzothiazole 82 | | Descriptor: | N-[6-(6-chloro-5-{[(4-fluorophenyl)sulfonyl]amino}pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | Authors: | Whittington, D.A, Tang, J, Yakowec, P. | | Deposit date: | 2011-01-31 | | Release date: | 2011-03-30 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors.
J.Med.Chem., 54, 2011
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1XPE
 | | HIV-1 subtype B genomic RNA Dimerization Initiation Site | | Descriptor: | 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3', CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Ennifar, E, Dumas, P. | | Deposit date: | 2004-10-08 | | Release date: | 2005-10-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Polymorphism of Bulged-out Residues in HIV-1 RNA DIS Kissing Complex and Structure Comparison with Solution Studies
J.Mol.Biol., 356, 2006
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