7PBD
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![BU of 7pbd by Molmil](/molmil-images/mine/7pbd) | a1b3 GABA-A receptor + GABA | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | Authors: | Miller, P.S, Kasaragod, V.B. | Deposit date: | 2021-08-02 | Release date: | 2022-02-09 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors. Nature, 602, 2022
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7OQH
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![BU of 7oqh by Molmil](/molmil-images/mine/7oqh) | CryoEM structure of the transcription termination factor Rho from Mycobacterium tuberculosis | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Transcription termination factor Rho | Authors: | Saridakis, E, Vishwakarma, R, Lai Kee Him, J, Martin, K, Simon, I, Cohen-Gonsaud, M, Coste, F, Bron, P, Margeat, E, Boudvillain, M. | Deposit date: | 2021-06-03 | Release date: | 2022-02-09 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism. Commun Biol, 5, 2022
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7OON
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![BU of 7oon by Molmil](/molmil-images/mine/7oon) | The X-ray structure of heme-bound murine HEBP1 | Descriptor: | Heme-binding protein 1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | McEwen, A.G, Poussin-Courmontagne, P, Birck, C, Goodfellow, B.J. | Deposit date: | 2021-05-28 | Release date: | 2022-01-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The SOUL family of heme-binding proteins: Structure and function 15 years later Coord. Chem. Rev, 448, 2021
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7OPO
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![BU of 7opo by Molmil](/molmil-images/mine/7opo) | RSK2 N-terminal kinase domain in complex with ORF45 | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein ORF45, Ribosomal protein S6 kinase alpha-3 | Authors: | Sok, P, Remenyi, A, Alexa, A, Poti, A. | Deposit date: | 2021-06-01 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host. Nat Commun, 13, 2022
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6IQ4
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![BU of 6iq4 by Molmil](/molmil-images/mine/6iq4) | Nucleosome core particle cross-linked with a hetero-binuclear molecule possessing RAPTA and gold(I) 4-(diphenylphosphino)benzoic acid groups. | Descriptor: | 4-diphenylphosphanylbenzoic acid, DNA (145-MER), GOLD ION, ... | Authors: | DeFalco, L, Batchelor, L.K, Adhireksan, Z, Dyson, P.J, Davey, C.A. | Deposit date: | 2018-11-06 | Release date: | 2019-10-30 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crosslinking Allosteric Sites on the Nucleosome. Angew.Chem.Int.Ed.Engl., 58, 2019
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6RT5
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![BU of 6rt5 by Molmil](/molmil-images/mine/6rt5) | |
6UM5
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![BU of 6um5 by Molmil](/molmil-images/mine/6um5) | Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Acharya, P, Henderson, R.C, Saunders, K.O, Haynes, B.F. | Deposit date: | 2019-10-09 | Release date: | 2019-12-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Science, 366, 2019
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6RZ7
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![BU of 6rz7 by Molmil](/molmil-images/mine/6rz7) | Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2570366 (F222 space group) | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2~{S})-8-[[4-[4-(2-chloranyl-5-fluoranyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3- dihydro-1,4-benzoxazine-2-carboxylic acid, CHOLESTEROL, ... | Authors: | Gusach, A, Luginina, A, Marin, E, Brouillette, R.L, Besserer-Offroy, E, Longpre, J.M, Ishchenko, A, Popov, P, Fujimoto, T, Maruyama, T, Stauch, B, Ergasheva, M, Romanovskaya, D, Stepko, A, Kovalev, K, Shevtsov, M, Gordeliy, V, Han, G.W, Sarret, P, Katritch, V, Borshchevskiy, V, Mishin, A, Cherezov, V. | Deposit date: | 2019-06-12 | Release date: | 2019-12-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nat Commun, 10, 2019
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6S0L
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![BU of 6s0l by Molmil](/molmil-images/mine/6s0l) | Structure of the A2A adenosine receptor determined at SwissFEL using native-SAD at 4.57 keV from all available diffraction patterns | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... | Authors: | Nass, K, Cheng, R, Vera, L, Mozzanica, A, Redford, S, Ozerov, D, Basu, S, James, D, Knopp, G, Cirelli, C, Martiel, I, Casadei, C, Weinert, T, Nogly, P, Skopintsev, P, Usov, I, Leonarski, F, Geng, T, Rappas, M, Dore, A.S, Cooke, R, Nasrollahi Shirazi, S, Dworkowski, F, Sharpe, M, Olieric, N, Steinmetz, M.O, Schertler, G, Abela, R, Patthey, L, Schmitt, B, Hennig, M, Standfuss, J, Wang, M, Milne, J.C. | Deposit date: | 2019-06-17 | Release date: | 2020-07-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Advances in long-wavelength native phasing at X-ray free-electron lasers. Iucrj, 7, 2020
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5HNR
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![BU of 5hnr by Molmil](/molmil-images/mine/5hnr) | The X-ray structure of octameric human native 5-aminolaevulinic acid dehydratase. | Descriptor: | DELTA-AMINO VALERIC ACID, Delta-aminolevulinic acid dehydratase, SULFATE ION, ... | Authors: | Mills-Davies, N.L, Thompson, D, Shoolingin-Jordan, P.M, Erskine, P.T, Cooper, J.B. | Deposit date: | 2016-01-18 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Structural studies of substrate and product complexes of 5-aminolaevulinic acid dehydratase from humans, Escherichia coli and the hyperthermophile Pyrobaculum calidifontis. Acta Crystallogr D Struct Biol, 73, 2017
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6E62
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![BU of 6e62 by Molmil](/molmil-images/mine/6e62) | Crystal structure of malaria transmission-blocking antigen Pfs48/45 6C in complex with antibody 85RF45.1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 85RF45.1 Fab heavy chain, 85RF45.1 Fab light chain, ... | Authors: | Kundu, P, Semesi, A, Julien, J.P. | Deposit date: | 2018-07-23 | Release date: | 2018-11-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45. Nat Commun, 9, 2018
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7SB8
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![BU of 7sb8 by Molmil](/molmil-images/mine/7sb8) | d(GA(CGA)5) parallel-stranded homo-duplex | Descriptor: | COBALT HEXAMMINE(III), GA(CGA)5, SODIUM ION, ... | Authors: | Luteran, E.M, Paukstelis, P.J. | Deposit date: | 2021-09-24 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.317 Å) | Cite: | The parallel-stranded d(CGA) duplex is a highly predictable structural motif with two conformationally distinct strands. Acta Crystallogr D Struct Biol, 78, 2022
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5LBM
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![BU of 5lbm by Molmil](/molmil-images/mine/5lbm) | The asymmetric tetrameric structure of the formaldehyde sensing transcriptional repressor FrmR from Escherichia coli | Descriptor: | FORMYL GROUP, Transcriptional repressor FrmR | Authors: | Bisson, C, Baker, P.J, Green, J, Chivers, P.T. | Deposit date: | 2016-06-16 | Release date: | 2016-12-21 | Last modified: | 2017-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The mechanism of a formaldehyde-sensing transcriptional regulator. Sci Rep, 6, 2016
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6RO4
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![BU of 6ro4 by Molmil](/molmil-images/mine/6ro4) | Structure of the core TFIIH-XPA-DNA complex | Descriptor: | DNA repair protein complementing XP-A cells, DNA1, DNA2, ... | Authors: | Kokic, G, Chernev, A, Tegunov, D, Dienemann, C, Urlaub, H, Cramer, P. | Deposit date: | 2019-05-10 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of TFIIH activation for nucleotide excision repair. Nat Commun, 10, 2019
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6RPH
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![BU of 6rph by Molmil](/molmil-images/mine/6rph) | TR-SMX open state structure (10-15ms) of bacteriorhodopsin | Descriptor: | Bacteriorhodopsin, RETINAL | Authors: | Weinert, T, Skopintsev, P, James, D, Kekilli, D, Furrer, A, Bruenle, S, Mous, S, Nogly, P, Standfuss, J. | Deposit date: | 2019-05-14 | Release date: | 2019-07-17 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Proton uptake mechanism in bacteriorhodopsin captured by serial synchrotron crystallography. Science, 365, 2019
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6I47
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![BU of 6i47 by Molmil](/molmil-images/mine/6i47) | Structure of P. aeruginosa LpxC with compound 10: (2RS)-4-(5-(2-Fluoro-4-methoxyphenyl)-1-oxoisoindolin-2-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide | Descriptor: | (2~{R})-4-[6-(2-fluoranyl-4-methoxy-phenyl)-3-oxidanylidene-1~{H}-isoindol-2-yl]-2-methyl-2-methylsulfonyl-~{N}-oxidanyl-butanamide, (2~{S})-4-[6-(2-fluoranyl-4-methoxy-phenyl)-3-oxidanylidene-1~{H}-isoindol-2-yl]-2-methyl-2-methylsulfonyl-~{N}-oxidanyl-butanamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ... | Authors: | Surivet, J.-P, Panchaud, P, Specklin, J.-L, Diethelm, S, Blumstein, A.-C, Gauvin, J.-C, Jacob, L, Masse, F, Mathieu, G, Mirre, A, Schmitt, C, Enderlin-Paput, M, Lange, R, Bur, D, Tidten-Luksch, N, Gnerre, C, Seeland, S, Hermann, C, Locher, H.H, Seiler, P, Mac Sweeney, A, Hubschwerlen, C, Ritz, D, Rueedi, G. | Deposit date: | 2018-11-09 | Release date: | 2019-12-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria. J.Med.Chem., 63, 2020
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8F2A
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![BU of 8f2a by Molmil](/molmil-images/mine/8f2a) | Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 (Cluster 5 conformation) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Cao, J, Sexton, P.M, Wootten, D.L, Radostin, D. | Deposit date: | 2022-11-07 | Release date: | 2023-08-02 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Structural insight into selectivity of amylin and calcitonin receptor agonists. Nat.Chem.Biol., 20, 2024
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8TL0
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![BU of 8tl0 by Molmil](/molmil-images/mine/8tl0) | |
6UFE
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![BU of 6ufe by Molmil](/molmil-images/mine/6ufe) | The structure of a potassium selective ion channel at atomic resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Transporter | Authors: | Langan, P.S, Vandavasi, V.G, Sullivan, B, Afonine, P.V, Weiss, K.L. | Deposit date: | 2019-09-24 | Release date: | 2020-08-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | The structure of a potassium-selective ion channel reveals a hydrophobic gate regulating ion permeation. Iucrj, 7, 2020
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7A52
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![BU of 7a52 by Molmil](/molmil-images/mine/7a52) | Structure of DYRK1A in complex with compound 6 | Descriptor: | 3-phenyl-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ... | Authors: | Dokurno, P, Surgenor, A.E, Hubbard, R.E. | Deposit date: | 2020-08-20 | Release date: | 2021-06-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
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7ZAV
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![BU of 7zav by Molmil](/molmil-images/mine/7zav) | GPC3-Unc5D octamer structure and role in cell migration | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glypican-3 | Authors: | Akkermans, O, Delloye-Bourgeois, C, Peregrina, C, Carrasquero, M, Kokolaki, M, Berbeira-Santana, M, Chavent, M, Reynaud, F, Ritu, R, Agirre, J, Aksu, M, White, E, Lowe, E, Ben Amar, D, Zaballa, S, Huo, J, Pakos, I, McCubbin, P, Comoletti, D, Owens, R, Robinson, C, Castellani, V, del Toro, D, Seiradake, E. | Deposit date: | 2022-03-22 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | GPC3-Unc5 receptor complex structure and role in cell migration. Cell, 185, 2022
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6KW4
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![BU of 6kw4 by Molmil](/molmil-images/mine/6kw4) | The ClassB RSC-Nucleosome Complex | Descriptor: | Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... | Authors: | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | Deposit date: | 2019-09-06 | Release date: | 2019-11-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (7.55 Å) | Cite: | Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
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6EGU
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![BU of 6egu by Molmil](/molmil-images/mine/6egu) | |
7S11
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![BU of 7s11 by Molmil](/molmil-images/mine/7s11) | Crystal structure of Fab in complex with mouse CD96 monomer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... | Authors: | Lee, P.S, Chau, B, Strop, P. | Deposit date: | 2021-08-31 | Release date: | 2021-11-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Antibody blockade of CD96 by distinct molecular mechanisms. Mabs, 13, 2021
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3I03
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![BU of 3i03 by Molmil](/molmil-images/mine/3i03) | Crystal structure of bothropstoxin-I chemically modified by p-bromophenacyl bromide (BPB) - monomeric form at a high resolution | Descriptor: | ISOPROPYL ALCOHOL, Phospholipase A2 homolog bothropstoxin-1, p-Bromophenacyl bromide | Authors: | Marchi-Salvador, D.P, Fernandes, C.A.H, Soares, A.M, Fontes, M.R.M. | Deposit date: | 2009-06-24 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca(2+)-binding loop region for the catalytically inactive Lys49-PLA(2)s. J.Struct.Biol., 171, 2010
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