6NM4
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![BU of 6nm4 by Molmil](/molmil-images/mine/6nm4) | Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor | Descriptor: | 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane, Histone-lysine N-methyltransferase PRDM9, S-ADENOSYLMETHIONINE, ... | Authors: | Ivanochko, D, Halabelian, L, Fischer, C, Sanders, J.M, Kattar, S.D, Brown, P.J, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | Deposit date: | 2019-01-10 | Release date: | 2019-02-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Discovery of a chemical probe for PRDM9. Nat Commun, 10, 2019
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7U3P
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![BU of 7u3p by Molmil](/molmil-images/mine/7u3p) | [3T7] Self-assembling tensegrity triangle with three turns of DNA per axis with R3 symmetry | Descriptor: | DNA (31-MER), DNA (5'-D(P*CP*CP*GP*TP*AP*CP*A)-3'), DNA (5'-D(P*GP*GP*CP*TP*GP*C)-3'), ... | Authors: | Woloszyn, K, Vecchioni, S, Lu, B, Ma, Y, Seeman, N.C, Sha, R, Ohayon, Y.P. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (6.06 Å) | Cite: | Augmented DNA Nanoarchitectures: A Structural Library of 3D Self-Assembling Tensegrity Triangle Variants. Adv Mater, 34, 2022
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7U3T
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![BU of 7u3t by Molmil](/molmil-images/mine/7u3t) | [F223] Self-assembling tensegrity triangle with two turns, two turns and three turns of DNA per axis by extension with P1 symmetry | Descriptor: | DNA (31-MER), DNA (5'-D(*AP*AP*CP*CP*TP*AP*CP*CP*TP*GP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*T)-3'), DNA (5'-D(*CP*AP*CP*GP*AP*GP*CP*CP*TP*GP*AP*TP*CP*GP*GP*AP*CP*AP*AP*GP*A)-3'), ... | Authors: | Woloszyn, K, Vecchioni, S, Seeman, N.C, Sha, R, Ohayon, Y.P, Zhu, E. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (4.69 Å) | Cite: | Augmented DNA Nanoarchitectures: A Structural Library of 3D Self-Assembling Tensegrity Triangle Variants. Adv Mater, 34, 2022
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7U3U
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![BU of 7u3u by Molmil](/molmil-images/mine/7u3u) | [L223] Self-assembling tensegrity triangle with two turns, two turns and three turns of DNA per axis by linker addition with P1 symmetry | Descriptor: | DNA (5'-D(*AP*AP*CP*CP*TP*AP*CP*TP*TP*GP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*T)-3'), DNA (5'-D(*AP*CP*GP*CP*GP*AP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), DNA (5'-D(*CP*AP*CP*GP*AP*GP*CP*CP*TP*GP*AP*TP*CP*GP*GP*AP*CP*AP*AP*GP*A)-3'), ... | Authors: | Woloszyn, K, Vecchioni, S, Seeman, N.C, Sha, R, Ohayon, Y.P. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (4.46 Å) | Cite: | Augmented DNA Nanoarchitectures: A Structural Library of 3D Self-Assembling Tensegrity Triangle Variants. Adv Mater, 34, 2022
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7U44
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![BU of 7u44 by Molmil](/molmil-images/mine/7u44) | [F344] Self-assembling tensegrity triangle with three turns, four turns and four turns of DNA per axis by extension with P1 symmetry | Descriptor: | DNA (31-MER), DNA (35-MER), DNA (42-MER), ... | Authors: | Woloszyn, K, Vecchioni, S, Seeman, N.C, Sha, R, Ohayon, Y.P. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (8.46 Å) | Cite: | Augmented DNA Nanoarchitectures: A Structural Library of 3D Self-Assembling Tensegrity Triangle Variants. Adv Mater, 34, 2022
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6V3J
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![BU of 6v3j by Molmil](/molmil-images/mine/6v3j) | KIR3DL1 in complex with HLA-B*57:03 presenting the peptide LSSPVTKSF | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, HLA-B alpha chain (B*5703GB), ... | Authors: | Maclachlan, B, Rossjohn, J, Vivian, J.P. | Deposit date: | 2019-11-25 | Release date: | 2020-05-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function. Proc.Natl.Acad.Sci.USA, 117, 2020
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8AXA
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![BU of 8axa by Molmil](/molmil-images/mine/8axa) | Cryo-EM structure of shCas12k-sgRNA-dsDNA ternary complex (type V-K CRISPR-associated transposon) | Descriptor: | Cas12k, DNA non-target strand, DNA target strand, ... | Authors: | Tenjo-Castano, F, Sofos, N, Stella, S, Fuglsang, A, Pape, T, Mesa, P, Stutzke, L.S, Temperini, P, Montoya, G. | Deposit date: | 2022-08-31 | Release date: | 2024-04-10 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Conformational landscape of the type V-K CRISPR-associated transposon integration assembly. Mol.Cell, 84, 2024
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6TK2
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![BU of 6tk2 by Molmil](/molmil-images/mine/6tk2) | Femtosecond to millisecond structural changes in a light-driven sodium pump: 1ms structure of KR2 with extrapolated, light and dark datasets | Descriptor: | EICOSANE, RETINAL, SODIUM ION, ... | Authors: | Skopintsev, P, Ehrenberg, D, Weinert, T, James, D, Kar, R, Johnson, P, Ozerov, D, Furrer, A, Martiel, I, Dworkowski, F, Nass, K, Knopp, G, Cirelli, C, Gashi, D, Mous, S, Wranik, M, Gruhl, T, Kekilli, D, Bruenle, S, Deupi, X, Schertler, G.F.X, Benoit, R, Panneels, V, Nogly, P, Schapiro, I, Milne, C, Heberle, J, Standfuss, J. | Deposit date: | 2019-11-28 | Release date: | 2020-05-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Femtosecond-to-millisecond structural changes in a light-driven sodium pump. Nature, 583, 2020
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6WOJ
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![BU of 6woj by Molmil](/molmil-images/mine/6woj) | Structure of the SARS-CoV-2 macrodomain (NSP3) in complex with ADP-ribose | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Non-structural protein 3 | Authors: | Lovell, S, Kashipathy, M.M, Battaile, K.P, Gao, F.P, Fehr, A.R. | Deposit date: | 2020-04-24 | Release date: | 2020-05-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase. J.Virol., 95, 2021
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8MSI
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![BU of 8msi by Molmil](/molmil-images/mine/8msi) | TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 N14SQ44T | Descriptor: | PROTEIN (ANTIFREEZE PROTEIN TYPE III) | Authors: | Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z. | Deposit date: | 1999-01-24 | Release date: | 1999-04-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Quantitative and qualitative analysis of type III antifreeze protein structure and function. J.Biol.Chem., 274, 1999
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5H0T
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![BU of 5h0t by Molmil](/molmil-images/mine/5h0t) | Crystal structure of proliferating cell nuclear antigen from Leishmania donovani at 2.73 Angstrom resolution | Descriptor: | DI(HYDROXYETHYL)ETHER, Proliferating cell nuclear antigen | Authors: | Singh, P.K, Yadav, S.P, Sharma, P.S, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2016-10-06 | Release date: | 2016-11-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Structure and binding studies of proliferating cell nuclear antigen from Leishmania donovani. Biochim. Biophys. Acta, 1865, 2017
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6CHY
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![BU of 6chy by Molmil](/molmil-images/mine/6chy) | STRUCTURE OF CHEMOTAXIS PROTEIN CHEY | Descriptor: | CHEY, SULFATE ION | Authors: | Zhu, X, Rebello, J, Matsumura, P, Volz, K. | Deposit date: | 1996-08-29 | Release date: | 1996-12-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Crystal structures of CheY mutants Y106W and T87I/Y106W. CheY activation correlates with movement of residue 106. J.Biol.Chem., 272, 1997
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4V9L
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![BU of 4v9l by Molmil](/molmil-images/mine/4v9l) | 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state. | Descriptor: | 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Zhou, J, Lancaster, L, Donohue, J.P, Noller, H.F. | Deposit date: | 2013-04-24 | Release date: | 2014-07-09 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation. Science, 340, 2013
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8BBY
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![BU of 8bby by Molmil](/molmil-images/mine/8bby) | |
7OPG
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![BU of 7opg by Molmil](/molmil-images/mine/7opg) | Crystal structure of CLK1 in complex with compound 2 (CC513) | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[2-(propylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenol, Dual specificity protein kinase CLK1, ... | Authors: | Chaikuad, A, Routier, S, Bonnet, P, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2021-05-31 | Release date: | 2021-07-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structure of CLK1 in complex with compound 2 (CC513) To Be Published
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7R6L
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![BU of 7r6l by Molmil](/molmil-images/mine/7r6l) | 5 prime exon-free pre-2S intermediate of the Tetrahymena group I intron, symmetry-expanded monomer from a synthetic dimeric construct | Descriptor: | Group I intron, 3 prime fragment plus 3 prime exon, 5 prime fragment, ... | Authors: | Thelot, F, Liu, D, Liao, M, Yin, P. | Deposit date: | 2021-06-22 | Release date: | 2022-05-04 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Sub-3- angstrom cryo-EM structure of RNA enabled by engineered homomeric self-assembly. Nat.Methods, 19, 2022
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6WTE
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![BU of 6wte by Molmil](/molmil-images/mine/6wte) | Structure of radical S-adenosylmethionine methyltransferase, TsrM, from Kitasatospora setae with cobalamin and [4Fe-4S] cluster bound | Descriptor: | 1,2-ETHANEDIOL, B12-binding domain-containing protein, COBALAMIN, ... | Authors: | Knox, H.L, Chen, P.Y.-T, Drennan, C.L, Booker, S.J. | Deposit date: | 2020-05-02 | Release date: | 2020-12-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Structural basis for non-radical catalysis by TsrM, a radical SAM methylase. Nat.Chem.Biol., 17, 2021
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7P3D
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![BU of 7p3d by Molmil](/molmil-images/mine/7p3d) | MHC I A02 Allele presenting YLQPRTFLL | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Beta-2-microglobulin, ... | Authors: | Rizkallah, P.J, Sewell, A.K, Wall, A, Fuller, A. | Deposit date: | 2021-07-07 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell, 185, 2022
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7MKY
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![BU of 7mky by Molmil](/molmil-images/mine/7mky) | SARS-CoV-2 frameshifting pseudoknot RNA | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, COBALT HEXAMMINE(III), MAGNESIUM ION, ... | Authors: | Jones, C.P, Ferre-D'Amare, A.R. | Deposit date: | 2021-04-27 | Release date: | 2021-05-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot. Rna, 28, 2022
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7MTL
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![BU of 7mtl by Molmil](/molmil-images/mine/7mtl) | |
6ZEK
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![BU of 6zek by Molmil](/molmil-images/mine/6zek) | Crystal structure of mouse CSAD | Descriptor: | CHLORIDE ION, COBALT (II) ION, Cysteine sulfinic acid decarboxylase, ... | Authors: | Mahootchi, E, Raasakka, A, Haavik, J, Kursula, P. | Deposit date: | 2020-06-16 | Release date: | 2021-04-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase. J.Struct.Biol., 213, 2021
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7YI2
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![BU of 7yi2 by Molmil](/molmil-images/mine/7yi2) | Cryo-EM structure of Rpd3S in loose-state Rpd3S-NCP complex | Descriptor: | Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... | Authors: | Li, H.T, Yan, C.Y, Guan, H.P, Wang, P. | Deposit date: | 2022-07-14 | Release date: | 2023-06-14 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature, 620, 2023
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7YI1
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![BU of 7yi1 by Molmil](/molmil-images/mine/7yi1) | Cryo-EM structure of Eaf3 CHD bound to H3K36me3 nucleosome | Descriptor: | Chromatin modification-related protein EAF3, Histone H2A, Histone H2B 1.1, ... | Authors: | Li, H.T, Yan, C.Y, Guan, H.P, Wang, P. | Deposit date: | 2022-07-14 | Release date: | 2023-06-14 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature, 620, 2023
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7M59
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![BU of 7m59 by Molmil](/molmil-images/mine/7m59) | |
5KMO
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![BU of 5kmo by Molmil](/molmil-images/mine/5kmo) | TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(2-pyridyl)urea | Descriptor: | 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-pyridin-2-yl-urea, High affinity nerve growth factor receptor | Authors: | Su, H.P. | Deposit date: | 2016-06-27 | Release date: | 2016-12-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Structural characterization of nonactive site, TrkA-selective kinase inhibitors. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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