6WTE

Structure of radical S-adenosylmethionine methyltransferase, TsrM, from Kitasatospora setae with cobalamin and [4Fe-4S] cluster bound

Summary for 6WTE

• Entry DOI: 10.2210/pdb6wte/pdb
• Related: 6WTF
• Descriptor: B12-binding domain-containing protein, IRON/SULFUR CLUSTER, COBALAMIN, ... (5 entities in total)
• Functional Keywords: radical sam, cobalamin, fes cluster, methyltransferase, transferase
• Biological source: Kitasatospora setae
• Total number of polymer chains: 2
• Total formula weight: 132754.52

Authors

Knox, H.L.,Chen, P.Y.-T.,Drennan, C.L.,Booker, S.J. (deposition date: 2020-05-02, release date: 2020-12-23, Last modification date: 2024-03-06)

• Primary citation: Knox, H.L.,Chen, P.Y.,Blaszczyk, A.J.,Mukherjee, A.,Grove, T.L.,Schwalm, E.L.,Wang, B.,Drennan, C.L.,Booker, S.J.; Structural basis for non-radical catalysis by TsrM, a radical SAM methylase.; Nat.Chem.Biol., 17:485-491, 2021; PubMed: 33462497; DOI: 10.1038/s41589-020-00717-y

Experimental method

X-RAY DIFFRACTION (1.67 Å)