6WTF

Structure of radical S-adenosylmethionine methyltransferase, TsrM, from Kitasatospora setae with tryptophan substrate and SAM analog (aza-SAM) bound

Summary for 6WTF

Entry DOI	10.2210/pdb6wtf/pdb
Related	6WTE
Descriptor	Tryptophan-C2-methyltransferase containing B12-binding domain, IRON/SULFUR CLUSTER, COBALAMIN, ... (6 entities in total)
Functional Keywords	radical sam, cobalamin, fes cluster, methyltransferase, transferase
Biological source	Kitasatospora setae
Total number of polymer chains	2
Total formula weight	132808.52
Authors	Knox, H.L.,Chen, P.Y.-T.,Drennan, C.L.,Booker, S.J. (deposition date: 2020-05-02, release date: 2020-12-23, Last modification date: 2023-10-18)
Primary citation	Knox, H.L.,Chen, P.Y.,Blaszczyk, A.J.,Mukherjee, A.,Grove, T.L.,Schwalm, E.L.,Wang, B.,Drennan, C.L.,Booker, S.J. Structural basis for non-radical catalysis by TsrM, a radical SAM methylase. Nat.Chem.Biol., 17:485-491, 2021 Cited by PubMed: 33462497 DOI: 10.1038/s41589-020-00717-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation