6TQT
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![BU of 6tqt by Molmil](/molmil-images/mine/6tqt) | The crystal structure of the MSP domain of human MOSPD2. | Descriptor: | 1,2-ETHANEDIOL, Motile sperm domain-containing protein 2, PHOSPHATE ION | Authors: | McEwen, A.G, Poussin-Courmontagne, P, Di Mattia, T, Wendling, C, Cavarelli, J, Tomasetto, C, Alpy, F. | Deposit date: | 2019-12-17 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts. Embo J., 39, 2020
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7MG8
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![BU of 7mg8 by Molmil](/molmil-images/mine/7mg8) | Concanavalin A bound to a DNA glycoconjugate, Man-CGCG | Descriptor: | 3-{[2-(2-hydroxyethoxy)ethyl]amino}-4-[(6-hydroxyhexyl)amino]cyclobut-3-ene-1,2-dione, CALCIUM ION, Concanavalin-A, ... | Authors: | Partridge, B.E, Winegar, P.H, Mirkin, C.A. | Deposit date: | 2021-04-12 | Release date: | 2021-06-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Redefining Protein Interfaces within Protein Single Crystals with DNA. J.Am.Chem.Soc., 143, 2021
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6R0C
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![BU of 6r0c by Molmil](/molmil-images/mine/6r0c) | Human-D02 Nucleosome Core Particle with biotin-streptavidin label | Descriptor: | DNA (142-MER), Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, ... | Authors: | Pye, V.E, Wilson, M.D, Cherepanov, P, Costa, A. | Deposit date: | 2019-03-12 | Release date: | 2019-09-25 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer. Nat Commun, 10, 2019
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6DWE
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![BU of 6dwe by Molmil](/molmil-images/mine/6dwe) | Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD0059-bound form | Descriptor: | (2R,3S,4R)-3-(2',6'-difluoro-4'-methyl[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile, 1,2-ETHANEDIOL, 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, ... | Authors: | Chang, C, Michalska, K, Maltseva, N.I, Jedrzejczak, R, McCarren, P, Nag, P.P, Joachimiak, A, Satchell, K, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-06-26 | Release date: | 2018-07-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.691 Å) | Cite: | Crystal structure of tryptophan synthase from M. tuberculosis - closed form with BRD6309 bound To be Published
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6NE8
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![BU of 6ne8 by Molmil](/molmil-images/mine/6ne8) | |
6U5B
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![BU of 6u5b by Molmil](/molmil-images/mine/6u5b) | CryoEM Structure of Pyocin R2 - precontracted - baseplate | Descriptor: | Glue PA0627, Ripcord PA0626, Sheath Initiator PA0617, ... | Authors: | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | Deposit date: | 2019-08-27 | Release date: | 2020-04-15 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
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6DN1
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![BU of 6dn1 by Molmil](/molmil-images/mine/6dn1) | CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1151 SPLIT RNA | Descriptor: | 10-(6-carboxyhexyl)-8-(cyclopentylamino)-2,4-dihydroxy-7-methylbenzo[g]pteridin-10-ium, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Vicens, Q, Mondragon, E, Reyes, F.E, Berman, J, Kaur, H, Kells, K, Wickens, P, Wilson, J, Gadwood, R, Schostarez, H, Suto, R.K, Coish, P, Blount, K.F, Batey, R.T. | Deposit date: | 2018-06-05 | Release date: | 2018-09-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch. ACS Chem. Biol., 13, 2018
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5HS3
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![BU of 5hs3 by Molmil](/molmil-images/mine/5hs3) | Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol, Thymidylate synthase | Authors: | Chen, D, Almqvist, H, Axelsson, H, Jafari, R, Mateus, A, Haraldsson, M, Larsson, A, Artursson, P, Molina, D.M, Lundback, T, Nordlund, P. | Deposit date: | 2016-01-25 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.103 Å) | Cite: | CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil Nat Commun, 7, 2016
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7MF7
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![BU of 7mf7 by Molmil](/molmil-images/mine/7mf7) | Crystal structure of antibody 10E8v4-P100gA Fab | Descriptor: | Antibody 10E8v4 Fab heavy chain, Antibody 10E8v4 Fab light chain | Authors: | Kwon, Y.D, Kwong, P.D. | Deposit date: | 2021-04-08 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography. Antibodies, 10, 2021
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6OP9
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![BU of 6op9 by Molmil](/molmil-images/mine/6op9) | HER3 pseudokinase domain bound to bosutinib | Descriptor: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Receptor tyrosine-protein kinase erbB-3 | Authors: | Littlefield, P, Agnew, C, Jura, N. | Deposit date: | 2019-04-24 | Release date: | 2019-08-21 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers. Cell Rep, 38, 2022
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6L9M
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![BU of 6l9m by Molmil](/molmil-images/mine/6l9m) | H2-Ld complexed with AH1 peptide | Descriptor: | H2-Ld, SER-PRO-SER-TYR-VAL-TYR-HIS-GLN-PHE, b2m | Authors: | Wei, P.C, Yin, L. | Deposit date: | 2019-11-10 | Release date: | 2020-11-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer. Proc.Natl.Acad.Sci.USA, 118, 2021
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6U4A
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![BU of 6u4a by Molmil](/molmil-images/mine/6u4a) | BRD3-BD1 in complex with the cyclic peptide 3.1_3 | Descriptor: | Bromodomain-containing protein 3, GLYCEROL, SULFATE ION, ... | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-24 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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4W9W
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![BU of 4w9w by Molmil](/molmil-images/mine/4w9w) | Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762 | Descriptor: | 1,2-ETHANEDIOL, 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide, BMP-2-inducible protein kinase | Authors: | Sorrell, F.J, Elkins, J.M, Krojer, T, Savitsky, P, Williams, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2014-08-28 | Release date: | 2014-09-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Family-wide Structural Analysis of Human Numb-Associated Protein Kinases. Structure, 24, 2016
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6R1J
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![BU of 6r1j by Molmil](/molmil-images/mine/6r1j) | Structure of the soluble AhlC triple head mutant of the tripartite alpha-pore forming toxin, AHL, from Aeromonas hydrophila. | Descriptor: | SODIUM ION, Uncharacterized protein | Authors: | Churchill-Angus, A.M, Wilson, J.S, Baker, P.J. | Deposit date: | 2019-03-14 | Release date: | 2019-07-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Identification and structural analysis of the tripartite alpha-pore forming toxin of Aeromonas hydrophila. Nat Commun, 10, 2019
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4WML
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![BU of 4wml by Molmil](/molmil-images/mine/4wml) | Crystal structure of Saccharomyces cerevisiae OMP synthase in complex with PRP(CH2)P | Descriptor: | 1-O-[(R)-hydroxy(phosphonomethyl)phosphoryl]-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, Orotate phosphoribosyltransferase 1 | Authors: | Bang, M.B, Molich, U, Hansen, M.R, Grubmeyer, C, Harris, P. | Deposit date: | 2014-10-09 | Release date: | 2015-12-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Crystal structure of Saccharomyces cerevisia OMP synthase in complex with PRP(CH2)P To Be Published
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8K65
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![BU of 8k65 by Molmil](/molmil-images/mine/8k65) | Serial femtosecond crystallography structure of CO bound ba3- type cytochrome c oxidase without pump laser irradiation | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CARBON MONOXIDE, COPPER (II) ION, ... | Authors: | Safari, C, Ghosh, S, Andersson, R, Johannesson, J, Donoso, A.V, Bath, P, Zoric, D, Sandelin, E, Nango, E, Tanaka, R, Iwata, S, Neutze, R, Branden, G. | Deposit date: | 2023-07-25 | Release date: | 2023-11-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase. Sci Adv, 9, 2023
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7MTG
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![BU of 7mtg by Molmil](/molmil-images/mine/7mtg) | Structure of the adeno-associated virus 9 capsid at pH 6.0 | Descriptor: | Capsid protein VP1 | Authors: | Penzes, J.J, Chipman, P, Bhattacharya, N, Zeher, A, Huang, R, McKenna, R, Agbandje-McKenna, M. | Deposit date: | 2021-05-13 | Release date: | 2021-07-21 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment. J.Virol., 95, 2021
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7MTP
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![BU of 7mtp by Molmil](/molmil-images/mine/7mtp) | Structure of the adeno-associated virus 9 capsid at pH 5.5 | Descriptor: | Capsid protein VP1 | Authors: | Penzes, J.J, Chipman, P, Bhattacharya, N, Zeher, A, Huang, R, McKenna, R, Agbandje-McKenna, M. | Deposit date: | 2021-05-13 | Release date: | 2021-07-21 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment. J.Virol., 95, 2021
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7R1V
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![BU of 7r1v by Molmil](/molmil-images/mine/7r1v) | |
7MTW
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![BU of 7mtw by Molmil](/molmil-images/mine/7mtw) | Structure of the adeno-associated virus 9 capsid at pH 4.0 | Descriptor: | Capsid protein VP1 | Authors: | Penzes, J.J, Chipman, P, Bhattacharya, N, Zeher, A, Huang, R, McKenna, R, Agbandje-McKenna, M. | Deposit date: | 2021-05-13 | Release date: | 2021-07-21 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment. J.Virol., 95, 2021
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5HP3
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![BU of 5hp3 by Molmil](/molmil-images/mine/5hp3) | Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AC mismatch at reaction site | Descriptor: | Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3'), ... | Authors: | Matthews, M.M, Fisher, A.J, Beal, P.A. | Deposit date: | 2016-01-20 | Release date: | 2016-04-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.091 Å) | Cite: | Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat.Struct.Mol.Biol., 23, 2016
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6R1Q
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![BU of 6r1q by Molmil](/molmil-images/mine/6r1q) | murine Neuroglobin under 2 kBar of argon | Descriptor: | ARGON, CHLORIDE ION, Neuroglobin, ... | Authors: | Prange, T, Colloc'h, N, Carpentier, P, Vallone, B. | Deposit date: | 2019-03-14 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Argon-labelling protein crystals by high pressure cooling at 2000 Bar To Be Published
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7R1W
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![BU of 7r1w by Molmil](/molmil-images/mine/7r1w) | E. coli BAM complex (BamABCDE) bound to dynobactin A | Descriptor: | Dynobactin A, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ... | Authors: | Jakob, R.P, Hiller, S, Maier, T. | Deposit date: | 2022-02-03 | Release date: | 2022-09-28 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Computational identification of a systemic antibiotic for gram-negative bacteria. Nat Microbiol, 7, 2022
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6U71
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![BU of 6u71 by Molmil](/molmil-images/mine/6u71) | BRD2-BD2 in complex with the cyclic peptide 3.1_3 | Descriptor: | Bromodomain-containing protein 2, cyclic peptide 3.1_3 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-31 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U8G
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![BU of 6u8g by Molmil](/molmil-images/mine/6u8g) | BRD4-BD2 in complex with the cyclic peptide 3.1_2_AcK7toA | Descriptor: | Bromodomain-containing protein 4, cyclic peptide 3.1_2_AcK7toA | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P, Mouradian, K.S. | Deposit date: | 2019-09-05 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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