5HS3

Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol

Summary for 5HS3

• Entry DOI: 10.2210/pdb5hs3/pdb
• Descriptor: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol, ... (4 entities in total)
• Functional Keywords: nhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 201704.37

Authors

Chen, D.,Almqvist, H.,Axelsson, H.,Jafari, R.,Mateus, A.,Haraldsson, M.,Larsson, A.,Artursson, P.,Molina, D.M.,Lundback, T.,Nordlund, P. (deposition date: 2016-01-25, release date: 2016-02-24, Last modification date: 2023-11-08)

• Primary citation: Almqvist, H.,Axelsson, H.,Jafari, R.,Chen, D.,Mateus, A.,Haraldsson, M.,Larsson, A.,Molina, D.M.,Artursson, P.,Lundback, T.,Nordlund, P.; CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil; Nat Commun, 7:11040-11040, 2016; PubMed: 27010513; DOI: 10.1038/ncomms11040

Experimental method

X-RAY DIFFRACTION (3.103 Å)