6DWE

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD0059-bound form

Summary for 6DWE

• Entry DOI: 10.2210/pdb6dwe/pdb
• Descriptor: Tryptophan synthase alpha chain, 1,2-ETHANEDIOL, TRIETHYLENE GLYCOL, ... (12 entities in total)
• Functional Keywords: plp, heterotetramer, amino acid biosynthesis, substrate channeling, allostery, structural genomics, center for structural genomics of infectious diseases, csgid, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Total number of polymer chains: 8
• Total formula weight: 293915.00

Authors

Chang, C.,Michalska, K.,Maltseva, N.I.,Jedrzejczak, R.,McCarren, P.,Nag, P.P.,Joachimiak, A.,Satchell, K.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2018-06-26, release date: 2018-07-11, Last modification date: 2023-10-11)

• Primary citation: Chang, C.,Michalska, K.,Maltseva, N.I.,Jedrzejczak, R.,McCarren, P.,Nag, P.P.,Joachimiak, A.,Satchell, K.; Crystal structure of tryptophan synthase from M. tuberculosis - closed form with BRD6309 bound; To be Published,

Experimental method

X-RAY DIFFRACTION (2.691 Å)