6DWE
Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and BRD0059-bound form
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, G, E, C | Tryptophan synthase alpha chain | polymer | 276 | 28579.4 | 4 | UniProt (P9WFY1) Pfam (PF00290) In PDB | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
2 | B, H, F, D | Tryptophan synthase beta chain | polymer | 410 | 43334.6 | 4 | UniProt (P9WFX9) Pfam (PF00291) In PDB | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
3 | C, A, E, G | MALONATE ION | non-polymer | 102.0 | 4 | Chemie (MLI) | |||
4 | G, H, C, D, A... | FORMIC ACID | non-polymer | 46.0 | 33 | Chemie (FMT) | |||
5 | H, D, B, F | 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID | non-polymer | 318.2 | 4 | Chemie (P1T) | |||
6 | H, D, B, F | CESIUM ION | non-polymer | 132.9 | 9 | Chemie (CS) | |||
7 | F, H, D, B | (2R,3S,4R)-3-(2',6'-difluoro-4'-methyl[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile | non-polymer | 316.3 | 4 | Chemie (HDJ) | |||
8 | H, B | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
9 | F, H | MALONIC ACID | non-polymer | 104.1 | 2 | Chemie (MLA) | |||
10 | F | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
11 | D | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
12 | water | water | 18.0 | 761 | Chemie (HOH) |
Sequence modifications
A, G, E, C: 1 - 270 (UniProt: P9WFY1)
PDB | External Database | Details |
---|---|---|
His 271 | - | expression tag |
His 272 | - | expression tag |
His 273 | - | expression tag |
His 274 | - | expression tag |
His 275 | - | expression tag |
His 276 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 287656.2 | |
Non-Polymers* | Number of molecules | 61 |
Total formula weight | 6258.8 | |
All* | Total formula weight | 293915.0 |