4J0S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4j0s by Molmil](/molmil-images/mine/4j0s) | Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand | 分子名称: | 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(S)-hydroxy(phenyl)methyl]phenol, Bromodomain-containing protein 4 | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, Hewings, D.S, von Delft, F, Conway, S.J, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2013-01-31 | 公開日 | 2013-02-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem., 56, 2013
|
|
6NJ3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nj3 by Molmil](/molmil-images/mine/6nj3) | |
4J4Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4j4q by Molmil](/molmil-images/mine/4j4q) | Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside | 分子名称: | ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ... | 著者 | Park, J.H, Morizumi, T, Li, Y, Hong, J.E, Pai, E.F, Hofmann, K.P, Choe, H.W, Ernst, O.P. | 登録日 | 2013-02-07 | 公開日 | 2013-10-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Opsin, a structural model for olfactory receptors? Angew.Chem.Int.Ed.Engl., 52, 2013
|
|
6GCJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gcj by Molmil](/molmil-images/mine/6gcj) | Solution structure of the RodA hydrophobin from Aspergillus fumigatus | 分子名称: | Hydrophobin | 著者 | Pille, A, Kwan, A, Aimanianda, V, Latge, J.-P, Sunde, M, Guijarro, J.I. | 登録日 | 2018-04-18 | 公開日 | 2019-03-27 | 最終更新日 | 2019-09-04 | 実験手法 | SOLUTION NMR | 主引用文献 | Assembly and disassembly of Aspergillus fumigatus conidial rodlets Cell Surf, 2019
|
|
3DPG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dpg by Molmil](/molmil-images/mine/3dpg) | SgrAI with noncognate DNA bound | 分子名称: | CALCIUM ION, DNA (5'-D(*DAP*DAP*DGP*DTP*DCP*DGP*DAP*DCP*DCP*DGP*DGP*DTP*DGP*DGP*DAP*DCP*DT)-3'), SgraIR restriction enzyme | 著者 | Dunten, P.W, Horton, N.C, Little, E.J. | 登録日 | 2008-07-08 | 公開日 | 2008-08-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | The structure of SgrAI bound to DNA; recognition of an 8 base pair target. Nucleic Acids Res., 36, 2008
|
|
3MW0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mw0 by Molmil](/molmil-images/mine/3mw0) | X-ray structure of the doubly hydroxylated iron complex-NikA species, NikA1/O2 | 分子名称: | 2-[2-[carboxymethyl-[(2-hydroxyphenyl)methyl]amino]ethyl-[(2,3-dihydroxyphenyl)methyl]amino]ethanoic acid, DITHIANE DIOL, FE (III) ION, ... | 著者 | Cavazza, C, Bochot, C, Rousselot-Pailley, P, Carpentier, P, Cherrier, M.V, Martin, L, Marchi-Delapierre, C, Fontecilla-Camps, J.C, Menage, S. | 登録日 | 2010-05-05 | 公開日 | 2011-02-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystallographic snapshots of the reaction of aromatic C-H with O(2) catalysed by a protein-bound iron complex NAT.CHEM., 2, 2010
|
|
5EKW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ekw by Molmil](/molmil-images/mine/5ekw) | A. thaliana IGPD2 in complex with the racemate of the triazole-phosphonate inhibitor, C348 | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Bisson, C, Britton, K.L, Sedelnikova, S.E, Rodgers, H.F, Eadsforth, T.C, Viner, R.C, Hawkes, T.R, Baker, P.J, Rice, D.W. | 登録日 | 2015-11-04 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Mirror-Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide. Angew.Chem.Int.Ed.Engl., 55, 2016
|
|
8V2O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v2o by Molmil](/molmil-images/mine/8v2o) | Cryo-EM Structure of Wildtype Smooth Muscle Gamma Actin (ACTG2) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, gamma-enteric smooth muscle, ... | 著者 | Palmer, N.J, Carman, P.J, Ceron, R.H, Dominguez, R. | 登録日 | 2023-11-23 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | 主引用文献 | Molecular mechanisms linking missense ACTG2 mutations to visceral myopathy. Sci Adv, 10, 2024
|
|
6NWG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nwg by Molmil](/molmil-images/mine/6nwg) | |
8V2Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v2z by Molmil](/molmil-images/mine/8v2z) | Cryo-EM Structure of Smooth Muscle Gamma Actin (ACTG2) Mutant R257C | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, gamma-enteric smooth muscle, ... | 著者 | Palmer, N.J, Carman, P.J, Ceron, R.H, Dominguez, R. | 登録日 | 2023-11-25 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | Smooth Muscle Gamma Actin (ACTG2) Filament Mutant R257C To Be Published
|
|
6NWU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nwu by Molmil](/molmil-images/mine/6nwu) | RORgamma Ligand Binding Domain | 分子名称: | 6-[(3,5-dichloropyridin-4-yl)methoxy]-1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2,3-dihydro-1H-indole, Nuclear receptor ROR-gamma | 著者 | Strutzenberg, T.S, Park, H, Griffin, P.R. | 登録日 | 2019-02-07 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | HDX-MS reveals structural determinants for ROR gamma hyperactivation by synthetic agonists. Elife, 8, 2019
|
|
4KRZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4krz by Molmil](/molmil-images/mine/4krz) | Apo crystal structure of pyruvate kinase (PYK) from Trypanosoma cruzi | 分子名称: | GLYCEROL, POTASSIUM ION, Pyruvate kinase | 著者 | Zhong, W, Morgan, H.P, McNae, I.W, Michels, P.A.M, Fothergill-Gilmore, L.A, Walkinshaw, M.D. | 登録日 | 2013-05-17 | 公開日 | 2014-11-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structures of pyruvate kinases display evolutionarily divergent allosteric strategies. R Soc Open Sci, 1, 2014
|
|
6VXN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vxn by Molmil](/molmil-images/mine/6vxn) | |
6FD5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6fd5 by Molmil](/molmil-images/mine/6fd5) | Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days post crystallization (with AMP and PPi products partially generated) | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, Adenine phosphoribosyltransferase, ... | 著者 | Nioche, P, Huyet, J, Ozeir, M. | 登録日 | 2017-12-21 | 公開日 | 2018-08-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase. Cell Chem Biol, 25, 2018
|
|
4BZT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bzt by Molmil](/molmil-images/mine/4bzt) | The Solution Structure of the MLN 944-d(ATGCAT)2 Complex | 分子名称: | 1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)-12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]PHENAZIN-10-IUM, DNA | 著者 | Serobian, A, Thomas, D.S, Ball, G.E, Denny, W.A, Wakelin, L.P.G. | 登録日 | 2013-07-30 | 公開日 | 2013-08-21 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The Solution Structure of Bis(Phenazine-1-Carboxamide)-DNA Complexes: Mln 944 Binding Corrected and Extended. Biopolymers, 101, 2014
|
|
6CCB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ccb by Molmil](/molmil-images/mine/6ccb) | Crystal structure of 253-11 SOSIP trimer in complex with 10-1074 Fab | 分子名称: | 10-1074 FAB heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Moyo, T, Ereno-Orbea, J, Dorfman, J, Julien, J.P. | 登録日 | 2018-02-06 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (6.5 Å) | 主引用文献 | Molecular Basis of Unusually High Neutralization Resistance in Tier 3 HIV-1 Strain 253-11. J. Virol., 92, 2018
|
|
6HEF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hef by Molmil](/molmil-images/mine/6hef) | Room temperature structure of the (SR)Ca2+-ATPase Ca2-E1-CaAMPPCP form | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | 著者 | Hjorth-Jensen, S, Sorensen, T.L.M, Oksanen, E, Andersen, J.L, Olesen, C, Moller, J.V, Nissen, P. | 登録日 | 2018-08-20 | 公開日 | 2018-08-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.538 Å) | 主引用文献 | Membrane-protein crystals for neutron diffraction. Acta Crystallogr D Struct Biol, 74, 2018
|
|
1U2A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1u2a by Molmil](/molmil-images/mine/1u2a) | |
3FQ5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fq5 by Molmil](/molmil-images/mine/3fq5) | |
5NB0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nb0 by Molmil](/molmil-images/mine/5nb0) | |
6FHC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6fhc by Molmil](/molmil-images/mine/6fhc) | |
8V4N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v4n by Molmil](/molmil-images/mine/8v4n) | Myxococcus xanthus EncA 3xHis pore mutant with T=1 icosahedral symmetry | 分子名称: | Type 1 encapsulin shell protein EncA | 著者 | Szyszka, T.N, Andreas, M.P, Lie, F, Miller, L.M, Adamson, L.S.R, Fatehi, F, Twarock, R, Draper, B.E, Jarrold, M.F, Giessen, T.W, Lau, Y.H. | 登録日 | 2023-11-29 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | Point mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
6MFH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mfh by Molmil](/molmil-images/mine/6mfh) | Mutated Uronate Dehydrogenase | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Mutated Uronate Dehydrogenase, PHOSPHATE ION | 著者 | Sankaran, B, Pereira, J.H, Chan, V, Zwart, P.H, Wagschal, K. | 登録日 | 2018-09-11 | 公開日 | 2019-09-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Chromohalobacter salixigens uronate dehydrogenase: Directed evolution for improved thermal stability and mutant CsUDH-inc X-ray crystal structure Process Biochem, 2020
|
|
3N7B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3n7b by Molmil](/molmil-images/mine/3n7b) | SgrAI bound to secondary site DNA and Ca(II) | 分子名称: | CALCIUM ION, DNA (5'-D(*AP*GP*TP*CP*CP*AP*CP*CP*GP*GP*GP*GP*GP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*CP*CP*CP*CP*CP*GP*GP*TP*GP*GP*AP*CP*T)-3'), ... | 著者 | Horton, N.C, Little, E.J, Dunten, P.W. | 登録日 | 2010-05-26 | 公開日 | 2010-11-24 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA. Acta Crystallogr.,Sect.D, 67, 2011
|
|
5EDT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5edt by Molmil](/molmil-images/mine/5edt) | Crystal structure of Mycobacterium tuberculosis CYP121 in complex with LIG9 | 分子名称: | 2-azanyl-5-chloranyl-benzamide, Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Kavanagh, M.E, Coyne, A.G, McLean, K.J, James, G.G, Levy, C, Marino, L.B, Carvalho, L.P.D, Chan, D.S.H, Hudson, S.A, Surade, S, Munro, A.W, Abell, C. | 登録日 | 2015-10-22 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
|
|