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PDB: 45955 件
4BIT
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BU of 4bit by Molmil
solution structure of cerebral dopamine neurotrophic factor (CDNF)
分子名称: CEREBRAL DOPAMINE NEUROTROPHIC FACTOR
著者Latge, C, Cabral, K.M.S, Raymundo, D.P, Foguel, D, Herrmann, T, Almeida, M.S.
登録日2013-04-13
公開日2014-04-23
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献The Solution Structure and Dynamics of Full-Length Human Cerebral Dopamine Neurotrophic Factor and its Neuroprotective Role Against Alpha-Synuclein Oligomers.
J.Biol.Chem., 290, 2015
7VAB
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BU of 7vab by Molmil
Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex
分子名称: CHOLESTEROL, Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W.
登録日2021-08-28
公開日2022-03-02
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
3PWB
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BU of 3pwb by Molmil
Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor
分子名称: BENZAMIDINE, CALCIUM ION, Cationic trypsin, ...
著者Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T.
登録日2010-12-08
公開日2011-12-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues.
Biol.Chem., 395, 2014
2BDI
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BU of 2bdi by Molmil
Human Kallikrein 4 complex with cobalt and p-aminobenzamidine
分子名称: COBALT (II) ION, Kallikrein-4, P-AMINO BENZAMIDINE
著者Debela, M, Bode, W, Goettig, P, Structural Proteomics in Europe (SPINE)
登録日2005-10-20
公開日2006-10-03
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.
J.Mol.Biol., 362, 2006
8BXU
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BU of 8bxu by Molmil
Crystal structure of Odorant Binding Protein 5 from Anopheles gambiae (AgamOBP5) with MPD (2-Methyl-2,4-pentanediol)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-ETHOXYETHANOL, Odorant binding protein, ...
著者Liggri, P.G.V, Tsitsanou, K.E, Zographos, S.E.
登録日2022-12-09
公開日2023-03-22
最終更新日2023-04-12
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献The structure of AgamOBP5 in complex with the natural insect repellents Carvacrol and Thymol: Crystallographic, fluorescence and thermodynamic binding studies.
Int.J.Biol.Macromol., 237, 2023
8BXV
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BU of 8bxv by Molmil
Crystal structure of Odorant Binding Protein 5 from Anopheles gambiae (AgamOBP5) with Thymol
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-METHYL-2-(1-METHYLETHYL)PHENOL, DI(HYDROXYETHYL)ETHER, ...
著者Liggri, P.G.V, Tsitsanou, K.E, Zographos, S.E.
登録日2022-12-10
公開日2023-03-22
最終更新日2023-04-12
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The structure of AgamOBP5 in complex with the natural insect repellents Carvacrol and Thymol: Crystallographic, fluorescence and thermodynamic binding studies.
Int.J.Biol.Macromol., 237, 2023
8BXW
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BU of 8bxw by Molmil
Crystal structure of Odorant Binding Protein 5 from Anopheles gambiae (AgamOBP5) with Carvacrol
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-BUTANOL, 2-methyl-5-propan-2-yl-phenol, ...
著者Liggri, P.G.V, Tsitsanou, K.E, Zographos, S.E.
登録日2022-12-10
公開日2023-03-22
最終更新日2023-04-12
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The structure of AgamOBP5 in complex with the natural insect repellents Carvacrol and Thymol: Crystallographic, fluorescence and thermodynamic binding studies.
Int.J.Biol.Macromol., 237, 2023
7VBI
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BU of 7vbi by Molmil
Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GLP-1R-Gs complex
分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W.
登録日2021-08-31
公開日2022-03-02
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
3HVT
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BU of 3hvt by Molmil
STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER
分子名称: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P51), HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66)
著者Steitz, T.A, Smerdon, S.J, Jaeger, J, Wang, J, Kohlstaedt, L.A, Chirino, A.J, Friedman, J.M, Rice, P.A.
登録日1994-07-25
公開日1994-10-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.
Proc.Natl.Acad.Sci.Usa, 91, 1994
6EEY
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BU of 6eey by Molmil
Crystal structure of human Scribble PDZ4 R1110G Mutant
分子名称: Protein scribble homolog
著者Janezic, E.M, Hsu, P, Hague, C.
登録日2018-08-15
公開日2019-10-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.145 Å)
主引用文献Scribble co-operatively binds multiple alpha1D-adrenergic receptor C-terminal PDZ ligands.
Sci Rep, 9, 2019
6UMV
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BU of 6umv by Molmil
Human apo PD-1 double mutant
分子名称: CHLORIDE ION, Programmed cell death protein 1
著者Tang, S, Kim, P.S.
登録日2019-10-10
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.424 Å)
主引用文献A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Proc.Natl.Acad.Sci.USA, 116, 2019
6EF5
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BU of 6ef5 by Molmil
14-3-3 with peptide
分子名称: 14-3-3 protein zeta/delta, ARG-SER-LEU-SEP-ALA-PRO-GLY, LYS-LEU-SEP-LEU-GLN
著者Dhagat, U, Langendorf, C.G, Parker, M.W.P, Oakhill, J.S, Scott, J.W.
登録日2018-08-16
公開日2019-10-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献14-3-3 with peptide
To Be Published
4PML
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BU of 4pml by Molmil
Crystal Structure of human Tankyrase 2 in complex with 3-amino-benzamide.
分子名称: 1,2-ETHANEDIOL, 3-aminobenzamide, DIMETHYL SULFOXIDE, ...
著者Qiu, W, Lam, R, Romanov, V, Gordon, R, Gebremeskel, S, Vodsedalek, J, Thompson, C, Beletskaya, I, Battaile, K.P, Pai, E.F, Chirgadze, N.Y.
登録日2014-05-22
公開日2014-10-15
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
Acta Crystallogr.,Sect.D, 70, 2014
6EDS
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BU of 6eds by Molmil
Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Glucagon and Substrate-selective Macrocyclic Inhibitor 63
分子名称: 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ...
著者Tan, G.A, Seeliger, M.A, Maianti, J.P, Liu, D.R, Welsh, A.J.
登録日2018-08-10
公開日2019-04-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.18071723 Å)
主引用文献Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Nat.Chem.Biol., 15, 2019
6LPW
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BU of 6lpw by Molmil
Structure of Spermidine disinapoyl transferases(SDT) from Arabidopsis thaliana
分子名称: SPERMIDINE, Spermidine sinapoyl-CoA acyltransferase
著者Wang, C.Y, Zhang, P.
登録日2020-01-12
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Structural and Biochemical Insights Into Two BAHD Acyltransferases ( At SHT and At SDT) Involved in Phenolamide Biosynthesis.
Front Plant Sci, 11, 2020
4PNL
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BU of 4pnl by Molmil
Crystal structure of TNKS-2 in complex with DR2313.
分子名称: 1,2-ETHANEDIOL, 2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ...
著者Qiu, W, Lam, R, Romanov, V, Gordon, R, Gebremeskel, S, Vodsedalek, J, Thompson, C, Beletskaya, I, Battaile, K.P, Pai, E.F, Chirgadze, N.Y.
登録日2014-05-23
公開日2014-10-15
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
Acta Crystallogr.,Sect.D, 70, 2014
5DYE
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BU of 5dye by Molmil
CRYSTAL STRUCTURE OF THE FULL LENGTH S156E MUTANT OF HUMAN AQUAPORIN 5
分子名称: Aquaporin-5, O-[(S)-{[(2S)-2-(hexanoyloxy)-3-(tetradecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-D-serine
著者Kitchen, P, Oeberg, F, Sjoehamn, J, Hedfalk, K, Bill, R.M, Conner, A.C, Conner, M.T, Toernroth-Horsefield, S.
登録日2015-09-24
公開日2015-12-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways.
Plos One, 10, 2015
2J1N
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BU of 2j1n by Molmil
osmoporin OmpC
分子名称: CHLORIDE ION, DODECANE, MAGNESIUM ION, ...
著者Basle, A, Storici, P, Rummel, G, Rosenbusch, J.P, Schirmer, T.
登録日2006-08-15
公開日2006-09-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Osmoporin Ompc from E. Coli at 2.0 A.
J.Mol.Biol., 362, 2006
8CEI
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BU of 8cei by Molmil
Succinyl-CoA Reductase from Clostridium kluyveri (SucD)
分子名称: Succinate-semialdehyde dehydrogenase (acetylating)
著者Pfister, P, Diehl, C, Erb, T.J.
登録日2023-02-02
公開日2023-05-31
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Enhancing the Substrate Specificity of Clostridium Succinyl-CoA Reductase for Synthetic Biology and Biocatalysis.
Biochemistry, 62, 2023
6AKZ
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BU of 6akz by Molmil
Crystal structure of GlcNAc Inducible Gene 2, GIG2 (DUF1479) from Candida albicans
分子名称: FE (III) ION, GlcNAc Inducible Gene 2, GIG2
著者Gautam, G, Rani, P, Dutta, A, Gourinath, S.
登録日2018-09-05
公開日2019-09-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Crystal structure of Gig2 protein from Candida albicans provides a structural insight into DUF1479 family oxygenases.
Int.J.Biol.Macromol., 150, 2020
6U4R
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BU of 6u4r by Molmil
Crystal structure of Equine Serum Albumin complex with ketoprofen
分子名称: (2S)-2-[3-(benzenecarbonyl)phenyl]propanoic acid, SULFATE ION, Serum albumin, ...
著者Czub, M.P, Handing, K.B, Shabalin, I.G, Satchell, K.J, Joachimiak, A, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2019-08-26
公開日2019-09-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Albumin-Based Transport of Nonsteroidal Anti-Inflammatory Drugs in Mammalian Blood Plasma.
J.Med.Chem., 63, 2020
6UAK
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LahSb - C-terminal methyltransferase involved in RiPP biosynthesis
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SAM dependent methyltransferase LahSB
著者Nair, S.K, Estrada, P.
登録日2019-09-10
公開日2019-12-04
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae.
Chembiochem, 21, 2020
5E7P
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BU of 5e7p by Molmil
Crystal Structure of MSMEG_0858 (Uniprot A0QQS4), a AAA ATPase.
分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein Cdc48, GLYCEROL, ...
著者Unciulac-Carp, M, Smith, P, Shuman, S.
登録日2015-10-12
公開日2016-08-24
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.507 Å)
主引用文献Crystal Structure and Biochemical Characterization of a Mycobacterium smegmatis AAA-Type Nucleoside Triphosphatase Phosphohydrolase (Msm0858).
J.Bacteriol., 198, 2016
8CFA
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BU of 8cfa by Molmil
HK97 Prohead II as part of a DNA packaging complex
分子名称: Major capsid subunit
著者Hawkins, D.E.D.P, Antson, A.A.
登録日2023-02-03
公開日2023-05-24
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.06 Å)
主引用文献Insights into a viral motor: the structure of the HK97 packaging termination assembly.
Nucleic Acids Res., 51, 2023
6U58
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BU of 6u58 by Molmil
Toho1 Beta Lactamase Glu166Gln Mutant
分子名称: Beta-lactamase, SULFATE ION
著者Langan, P.S, Sullivan, B, Weiss, K.L.
登録日2019-08-27
公開日2020-02-19
最終更新日2024-04-03
実験手法NEUTRON DIFFRACTION (1.9 Å), X-RAY DIFFRACTION
主引用文献Probing the Role of the Conserved Residue Glu166 in a Class A Beta-Lactamase Using Neutron and X-ray Protein Crystallography
Acta Crystallogr.,Sect.D, 76, 2020

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