4PNL

Crystal structure of TNKS-2 in complex with DR2313.

Summary for 4PNL

Entry DOI	10.2210/pdb4pnl/pdb
Related	4PML 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI
Descriptor	Tankyrase-2, ZINC ION, 2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one, ... (6 entities in total)
Functional Keywords	parp, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q9H2K2
Total number of polymer chains	4
Total formula weight	105510.45
Authors	Qiu, W.,Lam, R.,Romanov, V.,Gordon, R.,Gebremeskel, S.,Vodsedalek, J.,Thompson, C.,Beletskaya, I.,Battaile, K.P.,Pai, E.F.,Chirgadze, N.Y. (deposition date: 2014-05-23, release date: 2014-10-15, Last modification date: 2023-12-27)
Primary citation	Qiu, W.,Lam, R.,Voytyuk, O.,Romanov, V.,Gordon, R.,Gebremeskel, S.,Vodsedalek, J.,Thompson, C.,Beletskaya, I.,Battaile, K.P.,Pai, E.F.,Rottapel, R.,Chirgadze, N.Y. Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2. Acta Crystallogr.,Sect.D, 70:2740-2753, 2014 Cited by PubMed: 25286857 DOI: 10.1107/S1399004714017660 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation