1B39
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![BU of 1b39 by Molmil](/molmil-images/mine/1b39) | HUMAN CYCLIN-DEPENDENT KINASE 2 PHOSPHORYLATED ON THR 160 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PROTEIN (CELL DIVISION PROTEIN KINASE 2) | 著者 | Brown, N.R, Noble, M.E.M, Lawrie, A.M, Morris, M.C, Tunnah, P, Divita, G, Johnson, L.N, Endicott, J.A. | 登録日 | 1998-12-17 | 公開日 | 1998-12-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity. J.Biol.Chem., 274, 1999
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1HEL
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6YZL
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![BU of 6yzl by Molmil](/molmil-images/mine/6yzl) | Closo-carborane methyl-sulfonamide in complex with CA IX mimic | 分子名称: | Carbonic anhydrase 2, Carborane methyl-sulfonamide, ZINC ION | 著者 | Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. | 登録日 | 2020-05-07 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
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4LSP
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![BU of 4lsp by Molmil](/molmil-images/mine/4lsp) | Crystal structure of broadly and potently neutralizing antibody VRC-CH31 in complex with HIV-1 clade A/E gp120 93TH057 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | 著者 | Zhou, T, Moquin, S, Kwong, P.D. | 登録日 | 2013-07-23 | 公開日 | 2013-09-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies. Immunity, 39, 2013
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6YZP
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![BU of 6yzp by Molmil](/molmil-images/mine/6yzp) | Carborane nido-hexyl-sulfonamide in complex with CA IX mimic | 分子名称: | Carbonic anhydrase 2, Carborane nido-hexyl-sulfonamide, ZINC ION | 著者 | Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. | 登録日 | 2020-05-07 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
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6YZV
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![BU of 6yzv by Molmil](/molmil-images/mine/6yzv) | Closo-carborane ethyl-sulfonamide in complex with CA II | 分子名称: | Carbonic anhydrase 2, Carborane ethyl-sulfonamide, ZINC ION | 著者 | Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. | 登録日 | 2020-05-07 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem, 35, 2020
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1GW6
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![BU of 1gw6 by Molmil](/molmil-images/mine/1gw6) | STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT | 分子名称: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ... | 著者 | Rudberg, P.C, Tholander, F, Thunnissen, M.M.G.M, Samuelsson, B, Haeggstrom, J.Z. | 登録日 | 2002-03-07 | 公開日 | 2003-03-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Leukotriene A4 Hydrolase: Selective Abrogation of Leukotriene B4 Formation by Mutation of Aspartic Acid 375 Proc.Natl.Acad.Sci.USA, 99, 2002
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4RIB
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1TK1
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![BU of 1tk1 by Molmil](/molmil-images/mine/1tk1) | YEAST OXYGEN-DEPENDENT COPROPORPHYRINOGEN OXIDASE | 分子名称: | Coproporphyrinogen III oxidase | 著者 | Phillips, J.D, Whitby, F.G, Warby, C.A, Labbe, P, Yang, C, Pflugrath, J.W, Ferrara, J.D, Robinson, H, Kushner, J.P, Hill, C.P. | 登録日 | 2004-06-08 | 公開日 | 2004-07-20 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structure of the Oxygen-dependant Coproporphyrinogen Oxidase (Hem13p) of Saccharomyces cerevisiae J.Biol.Chem., 279, 2004
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1KOC
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![BU of 1koc by Molmil](/molmil-images/mine/1koc) | RNA APTAMER COMPLEXED WITH ARGININE, NMR | 分子名称: | ARGININE, RNA (5'-R(P*AP*CP*AP*GP*GP*UP*AP*GP*GP*UP*CP*GP*CP*U)-3'), RNA (5'-R(P*AP*GP*AP*AP*GP*GP*AP*GP*CP*GP*U)-3') | 著者 | Yang, Y.S, Kochoyan, M, Burgstaller, P, Westhof, E, Famulok, M. | 登録日 | 1996-03-28 | 公開日 | 1996-08-17 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis of ligand discrimination by two related RNA aptamers resolved by NMR spectroscopy. Science, 272, 1996
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7RKE
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![BU of 7rke by Molmil](/molmil-images/mine/7rke) | Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with 4-(((2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methyl)phenol and GRIP Peptide | 分子名称: | 4-{[(2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)amino]methyl}phenol, Estrogen receptor, Nuclear receptor coactivator 2 | 著者 | Joiner, C, Sammeta, V.K.R, Norris, J.D, McDonnell, D.P, Willson, T.M, Fanning, S.W. | 登録日 | 2021-07-22 | 公開日 | 2022-06-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3- d ]pyrimidine Core. Acs Med.Chem.Lett., 13, 2022
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8DVD
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1UYN
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![BU of 1uyn by Molmil](/molmil-images/mine/1uyn) | Translocator domain of autotransporter NalP from Neisseria meningitidis | 分子名称: | NALP, PENTAETHYLENE GLYCOL MONODECYL ETHER, SULFATE ION | 著者 | Oomen, C.J, Van Ulsen, P, Van Gelder, P, Feijen, M, Tommassen, J, Gros, P. | 登録日 | 2004-03-02 | 公開日 | 2004-03-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of the Translocator Domain of a Bacterial Autotransporter Embo J., 23, 2004
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6Z32
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![BU of 6z32 by Molmil](/molmil-images/mine/6z32) | Human cation-independent mannose 6-phosphate/IGF2 receptor domains 7-11 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, SULFATE ION, ... | 著者 | Bochel, A.J, Williams, C, McCoy, A.J, Hoppe, H, Winter, A.J, Nicholls, R.D, Harlos, K, Jones, Y.E, Berger, I, Hassan, B, Crump, M.P. | 登録日 | 2020-05-19 | 公開日 | 2020-08-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.47 Å) | 主引用文献 | Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9. Structure, 28, 2020
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400D
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1B20
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![BU of 1b20 by Molmil](/molmil-images/mine/1b20) | DELETION OF A BURIED SALT-BRIDGE IN BARNASE | 分子名称: | PROTEIN (BARNASE), ZINC ION | 著者 | Vaughan, C.K, Harryson, P, Buckle, A.M, Oliveberg, M, Fersht, A.R. | 登録日 | 1998-12-03 | 公開日 | 1998-12-09 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase. Acta Crystallogr.,Sect.D, 58, 2002
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6Z4Y
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![BU of 6z4y by Molmil](/molmil-images/mine/6z4y) | Crystal structure of Aurora A (STK6) in complex with macrocycle ODS2003208 | 分子名称: | 1,2-ETHANEDIOL, 6-(2-methoxyethoxy)-11-methyl-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one, Aurora kinase A, ... | 著者 | Chaikuad, A, Benderitter, P, Hoflack, J, Denis, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-05-26 | 公開日 | 2020-06-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal structure of Aurora A (STK6) in complex with macrocycle ODS2003208 To Be Published
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4X8D
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![BU of 4x8d by Molmil](/molmil-images/mine/4x8d) | Ergothioneine-biosynthetic sulfoxide synthase EgtB in complex with N,N-dimethyl-histidine and gamma-glutamyl-cysteine | 分子名称: | CALCIUM ION, CHLORIDE ION, GAMMA-GLUTAMYLCYSTEINE, ... | 著者 | Vit, A, Goncharenko, K.V, Blankenfeldt, W, Seebeck, F.P. | 登録日 | 2014-12-10 | 公開日 | 2015-01-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway. Angew.Chem.Int.Ed.Engl., 54, 2015
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6Z56
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![BU of 6z56 by Molmil](/molmil-images/mine/6z56) | Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003208 | 分子名称: | 6-(2-methoxyethoxy)-11-methyl-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one, DIMETHYL SULFOXIDE, Serine/threonine-protein kinase haspin | 著者 | Chaikuad, A, Benderitter, P, Hoflack, J, Denis, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-05-26 | 公開日 | 2020-06-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003208 To Be Published
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6Z59
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![BU of 6z59 by Molmil](/molmil-images/mine/6z59) | Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003816 | 分子名称: | 11-oxa-8,14,18,19,22-pentazatetracyclo[13.5.2.12,6.018,21]tricosa-1(21),2,4,6(23),15(22),16,19-heptaen-7-one, SODIUM ION, Serine/threonine-protein kinase haspin | 著者 | Chaikuad, A, Benderitter, P, Hoflack, J, Denis, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-05-26 | 公開日 | 2020-06-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of haspin (GSG2) in complex with macrocycle ODS2003816 To Be Published
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1V1K
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![BU of 1v1k by Molmil](/molmil-images/mine/1v1k) | CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR | 分子名称: | (2R)-1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OL, CELL DIVISION PROTEIN KINASE 2 | 著者 | Beattie, J.F, Breault, G.A, Ellston, R.P.A, Green, S, Jewsbury, P.J, Midgley, C.J, Naven, R.T, Minshull, C.A, Pauptit, R.A, Tucker, J.A, Pease, J.E. | 登録日 | 2004-04-16 | 公開日 | 2004-05-04 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Cyclin-Dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 1: Identification and Optimisation of Substituted 4,6-Bis Anilino Pyrimidines Bioorg.Med.Chem.Lett., 13, 2003
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1B2V
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![BU of 1b2v by Molmil](/molmil-images/mine/1b2v) | HEME-BINDING PROTEIN A | 分子名称: | CALCIUM ION, PROTEIN (HEME-BINDING PROTEIN A), PROTOPORPHYRIN IX CONTAINING FE | 著者 | Arnoux, P, Haser, R, Izadi, N, Lecroisey, A, Wandersma, N.C, Czjzek, M. | 登録日 | 1998-12-01 | 公開日 | 1999-06-24 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The crystal structure of HasA, a hemophore secreted by Serratia marcescens. Nat.Struct.Biol., 6, 1999
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8ECD
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![BU of 8ecd by Molmil](/molmil-images/mine/8ecd) | E. coli L-asparaginase II mutant (V27T) in complex with L-Asp | 分子名称: | 1,2-ETHANEDIOL, ASPARTIC ACID, CITRIC ACID, ... | 著者 | Strzelczyk, P, Wlodawer, A, Lubkowski, J. | 登録日 | 2022-09-01 | 公開日 | 2022-11-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | The E. coli L-asparaginase V27T mutant: structural and functional characterization and comparison with theoretical predictions. Febs Lett., 596, 2022
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6BLM
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3M2R
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![BU of 3m2r by Molmil](/molmil-images/mine/3m2r) | Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues | 分子名称: | 1,2-ETHANEDIOL, 1-THIOETHANESULFONIC ACID, Coenzyme B, ... | 著者 | Cedervall, P.E, Dey, M, Ragsdale, S.W, Wilmot, C.M. | 登録日 | 2010-03-08 | 公開日 | 2010-09-15 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues. Biochemistry, 49, 2010
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