4LSP

Crystal structure of broadly and potently neutralizing antibody VRC-CH31 in complex with HIV-1 clade A/E gp120 93TH057

Summary for 4LSP

• Entry DOI: 10.2210/pdb4lsp/pdb
• Related: 3NGB 3SE8 3SE9 4J6R 4JB9 4JPV 4JPW
• Descriptor: HIV-1 CLADE A/E STRAIN 93TH057 GP120, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31, ... (10 entities in total)
• Functional Keywords: neutralizing antibody vrc-ch31, hiv envelope glycoprotein gp120, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 3
• Total formula weight: 92129.59

Authors

Zhou, T.,Moquin, S.,Kwong, P.D. (deposition date: 2013-07-23, release date: 2013-09-04, Last modification date: 2023-09-20)

• Primary citation: Zhou, T.,Zhu, J.,Wu, X.,Moquin, S.,Zhang, B.,Acharya, P.,Georgiev, I.S.,Altae-Tran, H.R.,Chuang, G.Y.,Joyce, M.G.,Do Kwon, Y.,Longo, N.S.,Louder, M.K.,Luongo, T.,McKee, K.,Schramm, C.A.,Skinner, J.,Yang, Y.,Yang, Z.,Zhang, Z.,Zheng, A.,Bonsignori, M.,Haynes, B.F.,Scheid, J.F.,Nussenzweig, M.C.,Simek, M.,Burton, D.R.,Koff, W.C.,Mullikin, J.C.,Connors, M.,Shapiro, L.,Nabel, G.J.,Mascola, J.R.,Kwong, P.D.; Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.; Immunity, 39:245-258, 2013; PubMed: 23911655; DOI: 10.1016/j.immuni.2013.04.012

Experimental method

X-RAY DIFFRACTION (2.15 Å)