1AMU
 
 | | PHENYLALANINE ACTIVATING DOMAIN OF GRAMICIDIN SYNTHETASE 1 IN A COMPLEX WITH AMP AND PHENYLALANINE | | 分子名称: | ADENOSINE MONOPHOSPHATE, GRAMICIDIN SYNTHETASE 1, MAGNESIUM ION, ... | | 著者 | Conti, E, Stachelhaus, T, Marahiel, M.A, Brick, P. | | 登録日 | 1997-06-18 | | 公開日 | 1998-07-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S.
EMBO J., 16, 1997
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7WP9
 | | SARS-CoV-2 Omicron Variant SPIKE trimer, all RBDs down | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Yin, W, Xu, Y, Xu, P, Cao, X, Wu, C, Gu, C, He, X, Wang, X, Huang, S, Yuan, Q, Wu, K, Hu, W, Huang, Z, Liu, J, Wang, Z, Jia, F, Xia, K, Liu, P, Wang, X, Song, B, Zheng, J, Jiang, H, Cheng, X, Jiang, Y, Deng, S, Xu, E. | | 登録日 | 2022-01-23 | | 公開日 | 2022-03-09 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | | 主引用文献 | Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody.
Science, 375, 2022
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8CPQ
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7TBK
 | | Composite structure of the dilated human nuclear pore complex (NPC) symmetric core generated with a 37A in situ cryo-ET map of CD4+ T cell NPC | | 分子名称: | NUP107 CTD, NUP107 NTD, NUP133, ... | | 著者 | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | | 登録日 | 2021-12-22 | | 公開日 | 2022-06-15 | | 最終更新日 | 2022-06-22 | | 実験手法 | ELECTRON MICROSCOPY (37 Å) | | 主引用文献 | Architecture of the linker-scaffold in the nuclear pore.
Science, 376, 2022
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1A3P
 | | ROLE OF THE 6-20 DISULFIDE BRIDGE IN THE STRUCTURE AND ACTIVITY OF EPIDERMAL GROWTH FACTOR, NMR, 20 STRUCTURES | | 分子名称: | EPIDERMAL GROWTH FACTOR | | 著者 | Barnham, K, Torres, A, Alewood, D, Alewood, P, Domagala, T, Nice, E, Norton, R. | | 登録日 | 1998-01-22 | | 公開日 | 1998-07-29 | | 最終更新日 | 2018-03-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor.
Protein Sci., 7, 1998
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2R59
 | | Leukotriene A4 hydrolase complexed with inhibitor RB3041 | | 分子名称: | ACETIC ACID, Leukotriene A-4 hydrolase, N-{(2S)-3-[(R)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine, ... | | 著者 | Tholander, F, Haeggstrom, J.Z, Thunnissen, M, Muroya, A, Roques, B.P, Fournie-Zaluski, M.C. | | 登録日 | 2007-09-03 | | 公開日 | 2008-08-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
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5UFM
 | | Crystal structure of Burkholderia thailandensis 1,6-didemethyltoxoflavin-N1-methyltransferase with bound 1,6-didemethyltoxoflavin and S-adenosylhomocysteine | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Methyltransferase domain protein, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Fenwick, M.K, Ealick, S.E, Almabruk, K.H, Begley, T.P, Philmus, B. | | 登録日 | 2017-01-05 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Biochemistry, 56, 2017
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1A5D
 | | GAMMAE CRYSTALLIN FROM RAT LENS | | 分子名称: | GAMMAE CRYSTALLIN | | 著者 | Norledge, B.V, Hay, R, Bateman, O.A, Slingsby, C, Driessen, H.P.C. | | 登録日 | 1998-02-12 | | 公開日 | 1998-05-27 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Towards a molecular understanding of phase separation in the lens: a comparison of the X-ray structures of two high Tc gamma-crystallins, gammaE and gammaF, with two low Tc gamma-crystallins, gammaB and gammaD.
Exp.Eye Res., 65, 1997
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7TBJ
 | | Composite structure of the human nuclear pore complex (NPC) symmetric core generated with a 12A cryo-ET map of the purified HeLa cell NPC | | 分子名称: | NUP107 CTD, NUP107 NTD, NUP133, ... | | 著者 | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | | 登録日 | 2021-12-22 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-06-29 | | 実験手法 | ELECTRON MICROSCOPY (23 Å) | | 主引用文献 | Architecture of the linker-scaffold in the nuclear pore.
Science, 376, 2022
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8CPZ
 | | Photorhabdus luminescens TcdA1 prepore-to-pore intermediate, K1179W mutant | | 分子名称: | TcdA1 | | 著者 | Nganga, P.N, Roderer, D, Belyy, A, Prumbaum, D, Raunser, S. | | 登録日 | 2023-03-03 | | 公開日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Kinetics of the syringe-like injection mechanism of Tc toxins
to be published
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1EJZ
 | | SOLUTION STRUCTURE OF A HNA-RNA HYBRID | | 分子名称: | DNA (5'-H(*(6HG)P*(6HC)P*(6HG)P*(6HT)P*(6HA)P*(6HG)P*(6HC)P*(6HG))-3'), PHOSPHORIC ACID MONO-(3-HYDROXY-PROPYL) ESTER, RNA (5'-R(*CP*GP*CP*UP*AP*CP*GP*C)-3') | | 著者 | Lescrnier, E, Esnouf, R, Heus, H.A, Hilbers, C.W, Herdewijn, P. | | 登録日 | 2000-03-06 | | 公開日 | 2000-10-23 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a HNA-RNA hybrid.
Chem.Biol., 7, 2000
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5K7N
 | | MicroED structure of tau VQIVYK peptide at 1.1 A resolution | | 分子名称: | VQIVYK | | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | | 登録日 | 2016-05-26 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.1 Å) | | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
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3TUA
 | | Crystal Structure of the Burkholderia Lethal Factor 1 (BLF1) C94S mutant | | 分子名称: | Burkholderia Lethal Factor 1 (BLF1) | | 著者 | Cruz, A, Hautbergue, G.M, Artymiuk, P.J, Baker, P.J, Chang, C.T, Mahadi, N.M, Mobbs, G.W, Mohamed, R, Nathan, S, Partridge, L.J, Raih, M.F, Ruzheinikov, S.N, Sedelnikova, S.E, Wilson, S.A, Rice, D.W. | | 登録日 | 2011-09-16 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | | 主引用文献 | A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.
Science, 334, 2011
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1NM5
 | | R. rubrum transhydrogenase (dI.Q132N)2(dIII)1 asymmetric complex | | 分子名称: | GLYCEROL, NAD(P) transhydrogenase subunit alpha part 1, NAD(P) transhydrogenase subunit beta, ... | | 著者 | Van Boxel, G.I, Quirk, P.G, Cotton, N.P, White, S.A, Jackson, J.B. | | 登録日 | 2003-01-09 | | 公開日 | 2004-01-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Glutamine 132 in the NAD(H)-binding component of proton-translocating transhydrogenase tethers the nucleotides before hydride transfer.
Biochemistry, 42, 2003
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5KID
 | | Tightening the Recognition of Tetravalent Zr and Th Complexes by the Siderophore-Binding Mammalian Protein Siderocalin for Theranostic Applications | | 分子名称: | CHLORIDE ION, GLYCEROL, N,N'-(butane-1,4-diyl)bis(N-{3-[(2,3-dihydroxybenzene-1-carbonyl)amino]propyl}-2,3-dihydroxybenzamide), ... | | 著者 | Rupert, P.B, Strong, R.K. | | 登録日 | 2016-06-16 | | 公開日 | 2017-04-26 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator-Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms.
Inorg Chem, 55, 2016
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5UFN
 | | Crystal structure of Burkholderia thailandensis 1,6-didemethyltoxoflavin-N1-methyltransferase with bound S-adenosylhomocysteine | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Methyltransferase domain protein, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Fenwick, M.K, Ealick, S.E, Almabruk, K.H, Begley, T.P, Philmus, B. | | 登録日 | 2017-01-05 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Biochemistry, 56, 2017
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6J75
 | | Structure of 3,6-anhydro-L-galactose Dehydrogenase | | 分子名称: | Aldehyde dehydrogenase A | | 著者 | Li, P.Y, Wang, Y, Chen, X.L, Zhang, Y.Z. | | 登録日 | 2019-01-17 | | 公開日 | 2020-01-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.695 Å) | | 主引用文献 | 3,6-Anhydro-L-Galactose Dehydrogenase VvAHGD is a Member of a New Aldehyde Dehydrogenase Family and Catalyzes by a Novel Mechanism with Conformational Switch of Two Catalytic Residues Cysteine 282 and Glutamate 248.
J.Mol.Biol., 432, 2020
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4Q7S
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4Q81
 | | Crystal structure of 1-hydroxy-4,6-dimethylpyridine-2(1H)-thione bound to human carbonic anhydrase II | | 分子名称: | 1-hydroxy-4,6-dimethylpyridine-2(1H)-thione, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... | | 著者 | Martin, D.P, Cohen, S.M. | | 登録日 | 2014-04-25 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Exploring the influence of the protein environment on metal-binding pharmacophores.
J.Med.Chem., 57, 2014
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1E72
 | | Myrosinase from Sinapis alba with bound gluco-hydroximolactam and sulfate or ascorbate | | 分子名称: | (2S,3S,4R,5R)-6-(HYDROXYAMINO)-2-(HYDROXYMETHYL)-2,3,4,5-TETRAHYDROPYRIDINE-3,4,5-TRIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Burmeister, W.P. | | 登録日 | 2000-08-23 | | 公開日 | 2001-01-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | High resolution X-ray crystallography shows that ascorbate is a cofactor for myrosinase and substitutes for the function of the catalytic base.
J. Biol. Chem., 275, 2000
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4Q8Z
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1ANK
 | | THE CLOSED CONFORMATION OF A HIGHLY FLEXIBLE PROTEIN: THE STRUCTURE OF E. COLI ADENYLATE KINASE WITH BOUND AMP AND AMPPNP | | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENYLATE KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Berry, M.B, Meador, B, Bilderback, T, Liang, P, Glaser, M, Phillips Jr, G.N. | | 登録日 | 1994-02-28 | | 公開日 | 1994-05-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The closed conformation of a highly flexible protein: the structure of E. coli adenylate kinase with bound AMP and AMPPNP.
Proteins, 19, 1994
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6T7U
 | | Carborane inhibitor of Carbonic Anhydrase IX | | 分子名称: | Carbonic anhydrase 2, Carborane inhibitor, ZINC ION | | 著者 | Brynda, J, Rezacova, P, Kugler, M, Gruner, B. | | 登録日 | 2019-10-23 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX.
Eur.J.Med.Chem., 200, 2020
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5KH9
 | | Crystal structure of a low occupancy fragment candidate (5-[(4-Isopropylphenyl)amino]-6-methyl-1,2,4-triazin-3(2H)-one) bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain | | 分子名称: | 6-methyl-5-[(4-propan-2-ylphenyl)amino]-2~{H}-1,2,4-triazin-3-one, FORMIC ACID, Histone deacetylase 6, ... | | 著者 | Harding, R.J, Tempel, W, Ravichandran, M, Collins, P, Pearce, N, Brandao-Neto, J, Douangamath, A, Schapira, M, Bountra, C, Edwards, A.M, von Delft, F, Santhakumar, V, Arrowsmith, C.M, Structural Genomics Consortium (SGC) | | 登録日 | 2016-06-14 | | 公開日 | 2016-07-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | | 主引用文献 | Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.
J. Med. Chem., 60, 2017
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5KHP
 | | Tightening the Recognition of Tetravalent Zr and Th Complexes by the Siderophore-Binding Mammalian Protein Siderocalin for Theranostic Applications | | 分子名称: | GLYCEROL, N,N'-(butane-1,4-diyl)bis(N-{3-[(2,3-dihydroxybenzene-1-carbonyl)amino]propyl}-2,3-dihydroxybenzamide), Neutrophil gelatinase-associated lipocalin, ... | | 著者 | Rupert, P.B, Strong, R.K. | | 登録日 | 2016-06-15 | | 公開日 | 2017-04-26 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator-Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms.
Inorg Chem, 55, 2016
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