6T7U

Carborane inhibitor of Carbonic Anhydrase IX

Summary for 6T7U

Entry DOI	10.2210/pdb6t7u/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, Carborane inhibitor, ... (4 entities in total)
Functional Keywords	carbonic anhydrase ix, ca inhibitor, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29518.62
Authors	Brynda, J.,Rezacova, P.,Kugler, M.,Gruner, B. (deposition date: 2019-10-23, release date: 2020-06-17, Last modification date: 2024-01-24)
Primary citation	Dvoranova, J.,Kugler, M.,Holub, J.,Sicha, V.,Das, V.,Nekvinda, J.,El Anwar, S.,Havranek, M.,Pospisilova, K.,Fabry, M.,Kral, V.,Medvedikova, M.,Matejkova, S.,Liskova, B.,Gurska, S.,Dzubak, P.,Brynda, J.,Hajduch, M.,Gruner, B.,Rezacova, P. Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX. Eur.J.Med.Chem., 200:112460-112460, 2020 Cited by PubMed: 32505851 DOI: 10.1016/j.ejmech.2020.112460 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation