Crystal structure of 1-hydroxy-4-methylpyridin-2(1H)-one bound to human carbonic anhydrase II

Summary for 4Q8Z

Related4Q7P 4Q7S 4Q7V 4Q7W 4Q81 4Q83 4Q87 4Q8X 4Q8Y 4Q90 4Q99 4Q9Y 3M1K
DescriptorCarbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ... (5 entities in total)
Functional Keywordslyase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm  P00918
Total number of polymer chains1
Total molecular weight29801.3
Martin, D.P.,Cohen, S.M. (deposition date: 2014-04-28, release date: 2015-03-11)
Primary citation
Martin, D.P.,Blachly, P.G.,McCammon, J.A.,Cohen, S.M.
Exploring the influence of the protein environment on metal-binding pharmacophores.
J.Med.Chem., 57:7126-7135, 2014
PubMed: 25116076 (PDB entries with the same primary citation)
DOI: 10.1021/jm500984b
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.176500.5%0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4q8z
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Molmil generated image of 4q8z
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Molmil generated image of 4q8z
rotated about y axis by 90°