7B9B
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![BU of 7b9b by Molmil](/molmil-images/mine/7b9b) | Crystal structure of human 5' exonuclease Appollo APO form | Descriptor: | 5' exonuclease Apollo, NICKEL (II) ION | Authors: | Newman, J.A, Baddock, H.T, Mukhopadhyay, S.M.M, Burgess-Brown, N.A, von Delft, F, Arrowshmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | Deposit date: | 2020-12-14 | Release date: | 2021-01-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family. Nucleic Acids Res., 49, 2021
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7BTW
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![BU of 7btw by Molmil](/molmil-images/mine/7btw) | The mitochondrial SAM complex from S.cere | Descriptor: | Mitochondrial outer membrane beta-barrel protein, SAM37 isoform 1, Sorting assembly machinery 35 kDa subunit | Authors: | Takeda, H, Tsutsumi, A, Nishizawa, T, Nureki, O, Kikkawa, M, Endo, T. | Deposit date: | 2020-04-03 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mitochondrial sorting and assembly machinery operates by beta-barrel switching. Nature, 590, 2021
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7BJI
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![BU of 7bji by Molmil](/molmil-images/mine/7bji) | Crystal structure of the Danio rerio centrosomal protein Cep135 coiled-coil fragment 64-190 | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Centrosomal protein of 135 kDa, ... | Authors: | Li, Q, Hatzopoulos, G, Iller, O, Vakonakis, I. | Deposit date: | 2021-01-14 | Release date: | 2021-01-27 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Crystal structure of the Danio rerio centrosomal protein Cep135 coiled-coil fragment 64-190 To Be Published
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7BIO
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![BU of 7bio by Molmil](/molmil-images/mine/7bio) | Crystal structure of monooxygenase RslO4 from Streptomyces bottropensis | Descriptor: | ACETATE ION, ETHANOL, Monooxygenase/putative anthronoxygenase, ... | Authors: | Zhang, L, Zuo, C, Alali, A, Bechthold, A, Einsle, O. | Deposit date: | 2021-01-12 | Release date: | 2021-01-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.795 Å) | Cite: | Biosynthesis of the Tricyclic Aromatic Type II Polyketide Rishirilide: New Potential Third Ring Oxygenation after Three Cyclization Steps. Mol Biotechnol., 63, 2021
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7BTX
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![BU of 7btx by Molmil](/molmil-images/mine/7btx) | The mitochondrial SAM-Mdm10 supercomplex in GDN micelle from S.cere | Descriptor: | MDM10 isoform 1, Mitochondrial outer membrane beta-barrel protein, Sorting assembly machinery 35 kDa subunit, ... | Authors: | Takeda, H, Tsutsumi, A, Nishizawa, T, Nureki, O, Kikkawa, M, Endo, T. | Deposit date: | 2020-04-03 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mitochondrial sorting and assembly machinery operates by beta-barrel switching. Nature, 590, 2021
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7BTY
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![BU of 7bty by Molmil](/molmil-images/mine/7bty) | The mitochondrial SAM-Mdm10 supercomplex in Nanodisc from S.cere | Descriptor: | MDM10 isoform 1, Mitochondrial outer membrane beta-barrel protein, Sorting assembly machinery 35 kDa subunit, ... | Authors: | Takeda, H, Tsutsumi, A, Nishizawa, T, Nureki, O, Kikkawa, M, Endo, T. | Deposit date: | 2020-04-03 | Release date: | 2021-01-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mitochondrial sorting and assembly machinery operates by beta-barrel switching. Nature, 590, 2021
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7AQW
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![BU of 7aqw by Molmil](/molmil-images/mine/7aqw) | Cryo-EM structure of Arabidopsis thaliana Complex-I (membrane tip) | Descriptor: | (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Acyl carrier protein 1, mitochondrial, ... | Authors: | Klusch, N, Kuehlbrandt, W, Yildiz, O. | Deposit date: | 2020-10-23 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | A ferredoxin bridge connects the two arms of plant mitochondrial complex I. Plant Cell, 33, 2021
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7AQQ
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![BU of 7aqq by Molmil](/molmil-images/mine/7aqq) | Cryo-EM structure of Arabidopsis thaliana Complex-I (membrane core) | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, ... | Authors: | Klusch, N, Kuehlbrandt, W, Yildiz, O. | Deposit date: | 2020-10-22 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | A ferredoxin bridge connects the two arms of plant mitochondrial complex I. Plant Cell, 33, 2021
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7B4D
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![BU of 7b4d by Molmil](/molmil-images/mine/7b4d) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | Authors: | Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7AQR
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![BU of 7aqr by Molmil](/molmil-images/mine/7aqr) | Cryo-EM structure of Arabidopsis thaliana Complex-I (peripheral arm) | Descriptor: | Acyl carrier protein 2, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | Authors: | Klusch, N, Kuehlbrandt, W, Yildiz, O. | Deposit date: | 2020-10-22 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | A ferredoxin bridge connects the two arms of plant mitochondrial complex I. Plant Cell, 33, 2021
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7ARC
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![BU of 7arc by Molmil](/molmil-images/mine/7arc) | Cryo-EM structure of Polytomella Complex-I (peripheral arm) | Descriptor: | 13 kDa, 18 kDa, 24 kDa, ... | Authors: | Klusch, N, Kuehlbrandt, W, Yildiz, O. | Deposit date: | 2020-10-23 | Release date: | 2021-12-08 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | A ferredoxin bridge connects the two arms of plant mitochondrial complex I. Plant Cell, 33, 2021
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7B4N
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![BU of 7b4n by Molmil](/molmil-images/mine/7b4n) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (II) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | Authors: | Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7AR9
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![BU of 7ar9 by Molmil](/molmil-images/mine/7ar9) | Cryo-EM structure of Polytomella Complex-I (membrane arm) | Descriptor: | (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 15 kDa, AGGG, ... | Authors: | Klusch, N, Kuehlbrandt, W, Yildiz, O. | Deposit date: | 2020-10-23 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | A ferredoxin bridge connects the two arms of plant mitochondrial complex I. Plant Cell, 33, 2021
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7ARD
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![BU of 7ard by Molmil](/molmil-images/mine/7ard) | Cryo-EM structure of Polytomella Complex-I (complete composition) | Descriptor: | (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 13 kDa, 15 kDa, ... | Authors: | Klusch, N, Kuehlbrandt, W, Yildiz, O. | Deposit date: | 2020-10-23 | Release date: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | A ferredoxin bridge connects the two arms of plant mitochondrial complex I. Plant Cell, 33, 2021
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7B49
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![BU of 7b49 by Molmil](/molmil-images/mine/7b49) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | Authors: | Rozenberg, H, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B0W
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![BU of 7b0w by Molmil](/molmil-images/mine/7b0w) | Crystal structure of the E. coli type 1 pilus assembly inhibitor FimI bound to FimC | Descriptor: | 1,2-ETHANEDIOL, Chaperone protein FimC, FORMIC ACID, ... | Authors: | Scharer, M.A, Zigova, Z, Giese, C, Puorger, C, Ignatov, O, Capitani, G, Glockshuber, R. | Deposit date: | 2020-11-23 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Comprehensive kinetic characterization of bacterial pilus rod assembly and assembly termination To Be Published
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7B0X
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![BU of 7b0x by Molmil](/molmil-images/mine/7b0x) | Crystal structure of the ternary complex of the E. coli type 1 pilus proteins FimC, FimI and the N-terminal domain of FimD | Descriptor: | 1,2-ETHANEDIOL, Chaperone protein FimC, Fimbrin-like protein FimI, ... | Authors: | Scharer, M.A, Zigova, Z, Giese, C, Puorger, C, Ignatov, O, Capitani, G, Glockshuber, R. | Deposit date: | 2020-11-23 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Comprehensive kinetic characterization of bacterial pilus rod assembly and assembly termination To Be Published
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7B48
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![BU of 7b48 by Molmil](/molmil-images/mine/7b48) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (II) | Descriptor: | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B1N
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![BU of 7b1n by Molmil](/molmil-images/mine/7b1n) | |
7B1K
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![BU of 7b1k by Molmil](/molmil-images/mine/7b1k) | Crystal structure of phosphatidyl serine synthase (PSS) in the closed conformation with bound citrate. | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5'-O-[(R)-{[(S)-{(2R)-2,3-bis[(9E)-octadec-9-enoyloxy]propoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]cytidine, CALCIUM ION, ... | Authors: | Yildiz, O, Centola, M. | Deposit date: | 2020-11-25 | Release date: | 2021-12-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases Nat Commun, 12, 2021
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7B1L
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![BU of 7b1l by Molmil](/molmil-images/mine/7b1l) | Crystal structure of phosphatidyl serine synthase (PSS) in the closed conformation with bound citrate. | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5'-O-[(R)-{[(S)-{(2R)-2,3-bis[(9E)-octadec-9-enoyloxy]propoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]cytidine, CALCIUM ION, ... | Authors: | Yildiz, O, Centola, M. | Deposit date: | 2020-11-25 | Release date: | 2021-12-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases Nat Commun, 12, 2021
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7B4B
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![BU of 7b4b by Molmil](/molmil-images/mine/7b4b) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4G
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![BU of 7b4g by Molmil](/molmil-images/mine/7b4g) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (II) | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4F
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![BU of 7b4f by Molmil](/molmil-images/mine/7b4f) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I) | Descriptor: | Cellular tumor antigen p53, DNA target, FORMIC ACID, ... | Authors: | Rozenberg, H, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4H
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![BU of 7b4h by Molmil](/molmil-images/mine/7b4h) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (III) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | Authors: | Degtjarik, O, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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