5YFM
 
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5YFN
 | | Human isocitrate dehydrogenase 1 bound with isocitrate | | 分子名称: | ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, MAGNESIUM ION, ... | | 著者 | Nordlund, P, Chen, D, Jansson, A, Larsson, A. | | 登録日 | 2017-09-21 | | 公開日 | 2017-10-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Human isocitrate dehydrogenase 1 bound with isocitrate
To Be Published
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5WRN
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1HS6
 | | STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN. | | 分子名称: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ... | | 著者 | Thunnissen, M.M.G.M, Nordlund, P.N, Haeggstrom, J.Z. | | 登録日 | 2000-12-24 | | 公開日 | 2001-06-24 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.
Nat.Struct.Biol., 8, 2001
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2A98
 | | Crystal structure of the catalytic domain of human inositol 1,4,5-trisphosphate 3-kinase C | | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate 3-kinase C | | 著者 | Hallberg, B.M, Ogg, D, Ehn, M, Graslund, S, Hammarstrom, M, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Persson, C, Sagemark, J, Schuler, H, Stenmark, P, Thorsell, A.-G, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Structural Genomics Consortium (SGC) | | 登録日 | 2005-07-11 | | 公開日 | 2005-07-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The crystal structure of the catalytic domain of human inositol 1,4,5-trisphosphate 3-kinase C
To be Published
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2ACY
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1H78
 | | STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DCTP. | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE LARGE CHAIN, MAGNESIUM ION | | 著者 | Larsson, K.-M, Andersson, J, Sjoeberg, B.-M, Nordlund, P, Logan, D.T. | | 登録日 | 2001-07-04 | | 公開日 | 2002-07-04 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Basis for Allosteric Substrate Specificty Regulation in Anaerobic Ribonucleotide Reductase
Structure, 9, 2001
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1H7A
 | | Structural basis for allosteric substrate specificity regulation in class III ribonucleotide reductases: NRDD in complex with dATP | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE LARGE CHAIN, FE (II) ION, ... | | 著者 | Larsson, K.-M, Andersson, J, Sjoeberg, B.-M, Nordlund, P, Logan, D.T. | | 登録日 | 2001-07-04 | | 公開日 | 2002-03-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural Basis for Allosteric Substrate Specificty Regulation in Anaerobic Ribonucleotide Reductase
Structure, 9, 2001
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1H79
 | | STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DTTP | | 分子名称: | ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE LARGE CHAIN, FE (II) ION, MAGNESIUM ION, ... | | 著者 | Larsson, K.-M, Andersson, J, Sjoeberg, B.-M, Nordlund, P, Logan, D.T. | | 登録日 | 2001-07-04 | | 公開日 | 2002-03-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural Basis for Allosteric Substrate Specificty Regulation in Anaerobic Ribonucleotide Reductase
Structure, 9, 2001
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4XAL
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3B6E
 | | Crystal structure of human DECH-box RNA Helicase MDA5 (Melanoma differentiation-associated protein 5), DECH-domain | | 分子名称: | Interferon-induced helicase C domain-containing protein 1, SODIUM ION | | 著者 | Karlberg, T, Welin, M, Arrowsmith, C.H, Berglund, H, Busam, R.D, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Kotenyova, T, Lehtio, L, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC) | | 登録日 | 2007-10-29 | | 公開日 | 2007-11-13 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Human DECH-box RNA Helicase MDA5 (Melanoma differentiation-associated protein 5), DECH-domain.
To be Published
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3B7K
 | | Human Acyl-coenzyme A thioesterase 12 | | 分子名称: | Acyl-coenzyme A thioesterase 12, COENZYME A | | 著者 | Lehtio, L, Busam, R.D, Arrowsmith, C.H, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Herman, M.D, Johansson, A, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Sundstrom, M, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Berglund, H, Structural Genomics Consortium (SGC) | | 登録日 | 2007-10-31 | | 公開日 | 2007-11-13 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Human Acyl-coenzyme A thioesterase 12.
To be Published
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5HS3
 | | Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol, Thymidylate synthase | | 著者 | Chen, D, Almqvist, H, Axelsson, H, Jafari, R, Mateus, A, Haraldsson, M, Larsson, A, Artursson, P, Molina, D.M, Lundback, T, Nordlund, P. | | 登録日 | 2016-01-25 | | 公開日 | 2016-02-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.103 Å) | | 主引用文献 | CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Nat Commun, 7, 2016
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5EBE
 | | Structure of human sphingomyelinase phosphodiesterase like 3A (SMPDL3A) with 5' CMP | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-O-phosphono-beta-D-ribofuranose, ... | | 著者 | Lim, S.M, Yeung, K, Tresaugues, L, Teo, H.L, Nordlund, P. | | 登録日 | 2015-10-19 | | 公開日 | 2016-01-20 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a - an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
Febs J., 283, 2016
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1H7B
 | | Structural basis for allosteric substrate specificity regulation in class III ribonucleotide reductases, native NRDD | | 分子名称: | ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE LARGE CHAIN, PHOSPHATE ION | | 著者 | Larsson, K.-M, Andersson, J, Sjoeberg, B.-M, Nordlund, P, Logan, D.T. | | 登録日 | 2001-07-04 | | 公開日 | 2002-03-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structural Basis for Allosteric Substrate Specificty Regulation in Anaerobic Ribonucleotide Reductase
Structure, 9, 2001
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4TPJ
 | | Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2 | | 分子名称: | ALA-ALA-ALA, DODECYL-BETA-D-MALTOSIDE, Proton:oligopeptide symporter POT family, ... | | 著者 | Guettou, F, Quistgaard, E, Raba, M, Moberg, P, Low, C, Nordlund, P. | | 登録日 | 2014-06-07 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.201 Å) | | 主引用文献 | Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Nat.Struct.Mol.Biol., 21, 2014
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4TPH
 | | Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2 | | 分子名称: | 3,5 DIBROMOTYROSINE, ALANINE, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Guettou, F, Quistgaard, E, Raba, M, Moberg, P, Low, C, Nordlund, P. | | 登録日 | 2014-06-07 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.155 Å) | | 主引用文献 | Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Nat.Struct.Mol.Biol., 21, 2014
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4TPG
 | | Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2 | | 分子名称: | Ala-L-3-Br-Tyr-Ala, DODECYL-BETA-D-MALTOSIDE, Proton:oligopeptide symporter POT family, ... | | 著者 | Guettou, F, Quistgaard, E.M, Raba, M, Moberg, P, Low, C, Nordlund, P. | | 登録日 | 2014-06-07 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.91 Å) | | 主引用文献 | Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Nat.Struct.Mol.Biol., 21, 2014
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5EBB
 | | Structure of human sphingomyelinase phosphodiesterase like 3A (SMPDL3A) with Zn2+ | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, GLYCEROL, ... | | 著者 | Lim, S.M, Yeung, K, Tresaugues, L, Teo, H.L, Nordlund, P. | | 登録日 | 2015-10-19 | | 公開日 | 2016-01-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a - an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
Febs J., 283, 2016
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1BIQ
 | | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN MUTANT E238A | | 分子名称: | FE (II) ION, FE (III) ION, HYDROXIDE ION, ... | | 著者 | Logan, D.T, Demare, F, Persson, B.O, Slaby, A, Sjoberg, B.M, Nordlund, P. | | 登録日 | 1998-06-18 | | 公開日 | 1999-01-13 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal structures of two self-hydroxylating ribonucleotide reductase protein R2 mutants: structural basis for the oxygen-insertion step of hydroxylation reactions catalyzed by diiron proteins.
Biochemistry, 37, 1998
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5IPX
 | | Structure of ORF49 from KSHV | | 分子名称: | ORF49 protein, SULFATE ION | | 著者 | Hew, K, Nordlund, P. | | 登録日 | 2016-03-10 | | 公開日 | 2016-11-16 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of the Open Reading Frame 49 Protein Encoded by Kaposi's Sarcoma-Associated Herpesvirus.
J. Virol., 91, 2017
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3W51
 | | Tankyrase in complex with 2-hydroxy-4-methylquinoline | | 分子名称: | 4-methylquinolin-2-ol, SULFATE ION, Tankyrase-2, ... | | 著者 | Jansson, A.E, Larsson, E.A, Nordlund, P.L. | | 登録日 | 2013-01-18 | | 公開日 | 2013-07-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Fragment-based ligand design of novel potent inhibitors of tankyrases.
J.Med.Chem., 56, 2013
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5A7J
 | | Crystal structure of INPP5B in complex with benzene 1,2,4,5- tetrakisphosphate | | 分子名称: | (2,4,5-triphosphonooxyphenyl) dihydrogen phosphate, GLYCEROL, SULFATE ION, ... | | 著者 | Tresaugues, L, Mills, S.J, Silvander, C, Cozier, G, Potter, B.V.L, Nordlund, P. | | 登録日 | 2015-07-06 | | 公開日 | 2016-04-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Biochemistry, 55, 2016
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5BQK
 | | CRYSTAL STRUCTURE OF C-TERMINAL DOMAIN OF ICP27 PROTEIN FROM HSV-1 | | 分子名称: | ICP27, ZINC ION | | 著者 | Patel, V, Rajakannan, V, Dahlroth, S, Nordlund, P. | | 登録日 | 2015-05-29 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1.
J.Virol., 89, 2015
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4DT4
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