5EBB

Structure of human sphingomyelinase phosphodiesterase like 3A (SMPDL3A) with Zn2+

Summary for 5EBB

• Entry DOI: 10.2210/pdb5ebb/pdb
• Descriptor: Acid sphingomyelinase-like phosphodiesterase 3a, ZINC ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: calcineurin like phosphodiesterase, binuclear metallophosphodiesterase, acid sphingomyelinase like, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : Q92484
• Total number of polymer chains: 3
• Total formula weight: 142707.87

Authors

Lim, S.M.,Yeung, K.,Tresaugues, L.,Teo, H.L.,Nordlund, P. (deposition date: 2015-10-19, release date: 2016-01-20, Last modification date: 2020-07-29)

• Primary citation: Lim, S.M.,Yeung, K.,Tresaugues, L.,Ling, T.H.,Nordlund, P.; The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a - an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.; Febs J., 283:1107-1123, 2016; PubMed: 26783088; DOI: 10.1111/febs.13655

Experimental method

X-RAY DIFFRACTION (2.6 Å)