5EBB

Structure of human sphingomyelinase phosphodiesterase like 3A (SMPDL3A) with Zn2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004767	molecular_function	sphingomyelin phosphodiesterase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006685	biological_process	sphingomyelin catabolic process
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0008270	molecular_function	zinc ion binding
A	0009143	biological_process	nucleoside triphosphate catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
B	0004767	molecular_function	sphingomyelin phosphodiesterase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006685	biological_process	sphingomyelin catabolic process
B	0008081	molecular_function	phosphoric diester hydrolase activity
B	0008270	molecular_function	zinc ion binding
B	0009143	biological_process	nucleoside triphosphate catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
C	0004767	molecular_function	sphingomyelin phosphodiesterase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006685	biological_process	sphingomyelin catabolic process
C	0008081	molecular_function	phosphoric diester hydrolase activity
C	0008270	molecular_function	zinc ion binding
C	0009143	biological_process	nucleoside triphosphate catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0160049	biological_process	negative regulation of cGAS/STING signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26783088","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26783088","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26783088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28104755","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26783088","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28104755","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26783088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28104755","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---