5E1A
 
 | | Structure of KcsA with L24C/R117C mutations | | Descriptor: | POTASSIUM ION, antibody Fab fragment heavy chain, antibody Fab fragment light chain, ... | | Authors: | Upadhyay, V, Kim, D.M, Nimigean, C.M. | | Deposit date: | 2015-09-29 | | Release date: | 2016-07-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.
J.Gen.Physiol., 148, 2016
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4HZ3
 | | MthK pore crystallized in presence of TBSb | | Descriptor: | Calcium-gated potassium channel mthK, HEXANE-1,6-DIOL, POTASSIUM ION | | Authors: | Posson, D.J, McCoy, J.G, Nimigean, C.M. | | Deposit date: | 2012-11-14 | | Release date: | 2012-12-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.
Nat.Struct.Mol.Biol., 20, 2013
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4HYO
 | | Crystal Structure of MthK Pore | | Descriptor: | Calcium-gated potassium channel mthK, HEXANE-1,6-DIOL, POTASSIUM ION | | Authors: | Posson, D.J, McCoy, J.G, Nimigean, C.M. | | Deposit date: | 2012-11-13 | | Release date: | 2012-12-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The voltage-dependent gate in MthK potassium channels is located at the selectivity filter.
Nat.Struct.Mol.Biol., 20, 2013
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4CHW
 | | The electron crystallography structure of the cAMP-free potassium channel MloK1 | | Descriptor: | CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION | | Authors: | Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H. | | Deposit date: | 2013-12-04 | | Release date: | 2014-01-15 | | Last modified: | 2024-05-08 | | Method: | ELECTRON CRYSTALLOGRAPHY (7 Å) | | Cite: | Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.
Nat Commun, 5, 2014
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4CHV
 | | The electron crystallography structure of the cAMP-bound potassium channel MloK1 | | Descriptor: | CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION | | Authors: | Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H. | | Deposit date: | 2013-12-04 | | Release date: | 2014-01-15 | | Last modified: | 2024-05-08 | | Method: | ELECTRON CRYSTALLOGRAPHY (7 Å) | | Cite: | Ligand-Induced Structural Changes in the Cyclic Nucleotide-Modulated Potassium Channel Mlok1
Nat.Commun., 5, 2014
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5BKI
 | | Blocker-free closed MthK channel in nanodisc | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CADMIUM ION, Calcium-gated potassium channel MthK, ... | | Authors: | Fan, C, Nimigean, C.M. | | Deposit date: | 2021-03-19 | | Release date: | 2022-09-21 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Calcium-gated potassium channel blockade via membrane-facing fenestrations.
Nat.Chem.Biol., 2023
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5BKK
 | | bbTBA-bound closed MthK channel in nanodisc | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, (~{R})-phenyl-[4-[(tributyl-$l^{4}-azanyl)methyl]phenyl]methanol, Calcium-gated potassium channel MthK, ... | | Authors: | Fan, C, Nimigean, C.M. | | Deposit date: | 2021-03-19 | | Release date: | 2022-09-21 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Calcium-gated potassium channel blockade via membrane-facing fenestrations.
Nat.Chem.Biol., 2023
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5BKJ
 | | TPeA-bound closed MthK channel in nanodisc | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1-(tripentyl-$l^{4}-azanyl)pentane, Calcium-gated potassium channel MthK, ... | | Authors: | Fan, C, Nimigean, C.M. | | Deposit date: | 2021-03-19 | | Release date: | 2022-09-21 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Calcium-gated potassium channel blockade via membrane-facing fenestrations.
Nat.Chem.Biol., 2023
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8UC8
 | | HCN1 nanodisc | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | Authors: | Kim, E.D, Nimigean, C.M. | | Deposit date: | 2023-09-25 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
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8UC7
 | | HCN1 complex with propofol | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | Authors: | Kim, E.D, Nimigean, C.M. | | Deposit date: | 2023-09-25 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.
Nature, 632, 2024
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8VT9
 | | WT SthK in the presence of PIP2 and cAMP | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | | Authors: | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | | Deposit date: | 2024-01-26 | | Release date: | 2024-09-25 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.
Nat Commun, 15, 2024
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8VTA
 | | SthK R120A in the presence of PIP2 and cAMP | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | | Authors: | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | | Deposit date: | 2024-01-26 | | Release date: | 2024-09-25 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.
Nat Commun, 15, 2024
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8VTB
 | | SthK R120A R124A in the presence of PIP2 and cAMP | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | | Authors: | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | | Deposit date: | 2024-01-26 | | Release date: | 2024-09-25 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.
Nat Commun, 15, 2024
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6U5N
 | | Calcium-bound MthK gating ring state 2 | | Descriptor: | CALCIUM ION, Calcium-gated potassium channel MthK | | Authors: | Fan, C, Nimigean, C.M. | | Deposit date: | 2019-08-28 | | Release date: | 2020-03-25 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Ball-and-chain inactivation in a calcium-gated potassium channel.
Nature, 580, 2020
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6U9P
 | | Wild-type MthK pore in ~150 mM K+ | | Descriptor: | Calcium-gated potassium channel MthK, HEXANE-1,6-DIOL, POTASSIUM ION | | Authors: | Posson, D.J, Nimigean, C.M. | | Deposit date: | 2019-09-09 | | Release date: | 2020-11-04 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Selectivity filter ion binding affinity determines inactivation in a potassium channel.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6U6E
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6VY0
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6VXZ
 | | SthK P300A cyclic nucleotide-gated potassium channel in the closed state, in complex with cAMP | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | | Authors: | Schmidpeter, P.A.M, Rheinberger, J, Nimigean, C.M. | | Deposit date: | 2020-02-25 | | Release date: | 2020-11-11 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel.
Nat Commun, 11, 2020
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