4GL9
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![BU of 4gl9 by Molmil](/molmil-images/mine/4gl9) | Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain | Descriptor: | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Interleukin-6 receptor subunit beta, PHOSPHATE ION, ... | Authors: | Kershaw, N.J, Murphy, J.M, Laktyushin, A, Nicola, N.A, Babon, J.J. | Deposit date: | 2012-08-14 | Release date: | 2013-03-06 | Last modified: | 2018-06-13 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat.Struct.Mol.Biol., 20, 2013
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6C7Y
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![BU of 6c7y by Molmil](/molmil-images/mine/6c7y) | Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Liau, N.P.D, Laktyushin, A, Lucet, I.S, Murphy, J.M, Yao, S, Callaghan, K, Nicola, N.A, Kershaw, N.J, Babon, J.J. | Deposit date: | 2018-01-23 | Release date: | 2018-05-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | The molecular basis of JAK/STAT inhibition by SOCS1. Nat Commun, 9, 2018
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1A7M
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![BU of 1a7m by Molmil](/molmil-images/mine/1a7m) | LEUKAEMIA INHIBITORY FACTOR CHIMERA (MH35-LIF), NMR, 20 STRUCTURES | Descriptor: | LEUKEMIA INHIBITORY FACTOR | Authors: | Hinds, M.G, Maurer, T, Zhang, J.-G, Nicola, N.A, Norton, R.S. | Deposit date: | 1998-03-16 | Release date: | 1999-04-20 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution structure of leukemia inhibitory factor. J.Biol.Chem., 273, 1998
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4B8E
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![BU of 4b8e by Molmil](/molmil-images/mine/4b8e) | PRY-SPRY domain of Trim25 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, E3 UBIQUITIN/ISG15 LIGASE TRIM25 | Authors: | Kershaw, N.J, D'Cruz, A.A, Nicola, N.A, Nicholson, S.E, Babon, J.J. | Deposit date: | 2012-08-27 | Release date: | 2013-09-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.779 Å) | Cite: | Crystal Structure of the Trim25 B30.2 (Pryspry) Domain: A Key Component of Antiviral Signaling. Biochem.J., 456, 2013
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2JZ3
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![BU of 2jz3 by Molmil](/molmil-images/mine/2jz3) | SOCS box elonginBC ternary complex | Descriptor: | Suppressor of cytokine signaling 3, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2 | Authors: | Babon, J.J, Sabo, J, Soetopo, A, Yao, S, Bailey, M.F, Zhang, J, Nicola, N.A, Norton, R.S. | Deposit date: | 2007-12-27 | Release date: | 2008-09-23 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase J.Mol.Biol., 381, 2008
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2Q7N
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![BU of 2q7n by Molmil](/molmil-images/mine/2q7n) | Crystal structure of Leukemia inhibitory factor in complex with LIF receptor (domains 1-5) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Huyton, T, Zhang, J.G, Nicola, N.A, Garrett, T.P.J. | Deposit date: | 2007-06-07 | Release date: | 2007-07-31 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. Proc.Natl.Acad.Sci.USA, 104, 2007
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2AFJ
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![BU of 2afj by Molmil](/molmil-images/mine/2afj) | SPRY domain-containing SOCS box protein 2 (SSB-2) | Descriptor: | gene rich cluster, C9 gene | Authors: | Masters, S.L, Yao, S, Willson, T.A, Zhang, J.G, Palmer, K.R, Smith, B.J, Babon, J.J, Nicola, N.A, Norton, R.S, Nicholson, S.E. | Deposit date: | 2005-07-26 | Release date: | 2006-01-03 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues Nat.Struct.Mol.Biol., 13, 2006
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