1N1V
 
 | | Trypanosoma rangeli sialidase in complex with DANA | | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, SULFATE ION, Sialidase | | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | | Deposit date: | 2002-10-21 | | Release date: | 2003-01-07 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The high resolution structures of free and
inhibitor-bound Trypanosoma rangeli
sialidase and its comparison with T.
cruzi trans-sialidase
J.Mol.Biol., 325, 2003
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6LD8
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6LGO
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6LD9
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6LD7
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5K5T
 | | Crystal structure of the inactive form of human calcium-sensing receptor extracellular domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Extracellular calcium-sensing receptor, ... | | Authors: | Geng, Y, Mosyak, L, Kurinov, I, Zuo, H, Sturchler, E, Cheng, T.C, Subramanyam, P, Brown, A.P, Brennan, S.C, Mun, H.-C, Bush, M, Chen, Y, Nguyen, T, Cao, B, Chang, D, Quick, M, Conigrave, A, Colecraft, H.M, McDonald, P, Fan, Q.R. | | Deposit date: | 2016-05-23 | | Release date: | 2016-08-03 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural mechanism of ligand activation in human calcium-sensing receptor.
Elife, 5, 2016
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5K5S
 | | Crystal structure of the active form of human calcium-sensing receptor extracellular domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Extracellular calcium-sensing receptor, ... | | Authors: | Geng, Y, Mosyak, L, Kurinov, I, Zuo, H, Sturchler, E, Cheng, T.C, Subramanyam, P, Brown, A.P, Brennan, S.C, Mun, H.-C, Bush, M, Chen, Y, Nguyen, T, Cao, B, Chang, D, Quick, M, Conigrave, A, Colecraft, H.M, McDonald, P, Fan, Q.R. | | Deposit date: | 2016-05-23 | | Release date: | 2016-08-03 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural mechanism of ligand activation in human calcium-sensing receptor.
Elife, 5, 2016
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8JCD
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8JBX
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8OX0
 | | Structure of apo telomeric nucleosome | | Descriptor: | Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, Histone H3.1, ... | | Authors: | Hu, H, van Roon, A.M.M, Ghanim, G.E, Ahsan, B, Oluwole, A, Peak-Chew, S, Robinson, C.V, Nguyen, T.H.D. | | Deposit date: | 2023-04-28 | | Release date: | 2023-08-30 | | Last modified: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (2.52 Å) | | Cite: | Structural basis of telomeric nucleosome recognition by shelterin factor TRF1.
Sci Adv, 9, 2023
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8OX1
 | | Structure of TRF1core in complex with telomeric nucleosome | | Descriptor: | Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, Histone H3.1, ... | | Authors: | Hu, H, van Roon, A.M.M, Ghanim, G.E, Ahsan, B, Oluwole, A, Peak-Chew, S, Robinson, C.V, Nguyen, T.H.D. | | Deposit date: | 2023-04-28 | | Release date: | 2023-08-30 | | Last modified: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis of telomeric nucleosome recognition by shelterin factor TRF1.
Sci Adv, 9, 2023
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8PK0
 | | human mitoribosomal large subunit assembly intermediate 1 with GTPBP10-GTPBP7 | | Descriptor: | 16S rRNA + pre-H68-71 segment, 39S ribosomal protein L10, mitochondrial, ... | | Authors: | Kummer, E, Nguyen, T.G, Ritter, C. | | Deposit date: | 2023-06-23 | | Release date: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
Nat Commun, 14, 2023
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8OUE
 | | The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in a semi-closed conformation | | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | | Authors: | Ghanim, G.E, Sekne, Z, van Roon, A.M.M, Balch, S, Nguyen, T.H.D. | | Deposit date: | 2023-04-22 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | 2.7 angstrom cryo-EM structure of human telomerase H/ACA ribonucleoprotein.
Nat Commun, 15, 2024
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8OUF
 | | The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in an open conformation | | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | | Authors: | Ghanim, G.E, Sekne, Z, van Roon, A.M.M, Balch, S, Nguyen, T.H.D. | | Deposit date: | 2023-04-22 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | 2.7 angstrom cryo-EM structure of human telomerase H/ACA ribonucleoprotein.
Nat Commun, 15, 2024
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7A4X
 | | tRNA-guanine transglycosylase C158S/C281S/Y330C/H333A mutant in complex with dimethyl sulfoxide | | Descriptor: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, GLYCEROL, ... | | Authors: | Nguyen, D, Nguyen, T.X.P, Heine, A, Klebe, G. | | Deposit date: | 2020-08-20 | | Release date: | 2021-06-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
Acs Chem.Biol., 16, 2021
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8JCE
 | | Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with m7GpppAmU | | Descriptor: | MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | | Authors: | Zhang, K, Law, M.C.Y, Nguyen, T.M, Tan, Y.B, Wirawan, M, Law, Y.S, Luo, D.H. | | Deposit date: | 2023-05-11 | | Release date: | 2023-11-15 | | Last modified: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (2.41 Å) | | Cite: | Chikungunya virus nonstructural protein 1 is a versatile RNA capping and decapping enzyme.
J.Biol.Chem., 299, 2023
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6JDK
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7X3N
 | | Crystal structure of anti-mPEG h15-2b Fab | | Descriptor: | 15-2b-H, 15-2b-L, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL | | Authors: | Chang, C.Y, Nguyen, T.M.T, Toh, S.I, Su, Y.C. | | Deposit date: | 2022-03-01 | | Release date: | 2023-03-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group
Commun Chem, 5, 2022
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7Y0G
 | | Crystal structure of anti-mPEG h15-2b Fab | | Descriptor: | 15-2b heavy chain, 15-2b light chain, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL | | Authors: | Chang, C.Y, Nguyen, T.M.T, Lin, E.C, Su, Y.C. | | Deposit date: | 2022-06-05 | | Release date: | 2022-08-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group.
Commun Chem, 5, 2022
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7COK
 | | Crystal structure of ligand-free form of 5-ketofructose reductase of Gluconobacter sp. strain CHM43 | | Descriptor: | 5-ketofructose reductase | | Authors: | Noda, S, Hodoya, Y, Nguyen, T.M, Kataoka, N, Adachi, O, Matsutani, M, Matsushita, K, Yakushi, T, Goto, M. | | Deposit date: | 2020-08-04 | | Release date: | 2021-08-04 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The 5-Ketofructose Reductase of Gluconobacter sp. Strain CHM43 Is a Novel Class in the Shikimate Dehydrogenase Family.
J.Bacteriol., 203, 2021
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7COL
 | | Crystal structure of 5-ketofructose reductase complexed with NADPH | | Descriptor: | 5-ketofructose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Hodoya, Y, Noda, S, Nguyen, T.M, Kataoka, N, Adachi, O, Matsutani, M, Matsushita, K, Yakushi, T, Goto, M. | | Deposit date: | 2020-08-04 | | Release date: | 2021-08-04 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The 5-Ketofructose Reductase of Gluconobacter sp. Strain CHM43 Is a Novel Class in the Shikimate Dehydrogenase Family.
J.Bacteriol., 203, 2021
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1C4R
 | | THE STRUCTURE OF THE LIGAND-BINDING DOMAIN OF NEUREXIN 1BETA: REGULATION OF LNS DOMAIN FUNCTION BY ALTERNATIVE SPLICING | | Descriptor: | NEUREXIN-I BETA | | Authors: | Rudenko, G, Nguyen, T, Chelliah, Y, Sudhof, T.C, Deisenhofer, J. | | Deposit date: | 1999-09-28 | | Release date: | 2000-10-04 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing.
Cell(Cambridge,Mass.), 99, 1999
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8SZJ
 | | Human glutaminase C (Y466W) with L-Gln and Pi, filamentous form | | Descriptor: | GLUTAMINE, Glutaminase kidney isoform, mitochondrial, ... | | Authors: | Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A. | | Deposit date: | 2023-05-29 | | Release date: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Filament formation drives catalysis by glutaminase enzymes important in cancer progression.
Nat Commun, 15, 2024
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8T0Z
 | | Human liver-type glutaminase (K253A) with L-Gln, filamentous form | | Descriptor: | GLUTAMINE, Glutaminase liver isoform, mitochondrial | | Authors: | Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A. | | Deposit date: | 2023-06-01 | | Release date: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Filament formation drives catalysis by glutaminase enzymes important in cancer progression.
Nat Commun, 15, 2024
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8SZL
 | | Human liver-type glutaminase (Apo form) | | Descriptor: | Glutaminase liver isoform, mitochondrial | | Authors: | Feng, S, Aplin, C, Nguyen, T.-T.T, Milano, S.K, Cerione, R.A. | | Deposit date: | 2023-05-30 | | Release date: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Filament formation drives catalysis by glutaminase enzymes important in cancer progression.
Nat Commun, 15, 2024
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