8SZJ
Human glutaminase C (Y466W) with L-Gln and Pi, filamentous form
Summary for 8SZJ
Entry DOI | 10.2210/pdb8szj/pdb |
EMDB information | 40918 |
Descriptor | Glutaminase kidney isoform, mitochondrial, PHOSPHATE ION, GLUTAMINE (3 entities in total) |
Functional Keywords | cancer, filament, metabolism, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 12 |
Total formula weight | 789660.82 |
Authors | Feng, S.,Aplin, C.,Nguyen, T.-T.T.,Milano, S.K.,Cerione, R.A. (deposition date: 2023-05-29, release date: 2024-03-13) |
Primary citation | Feng, S.,Aplin, C.,Nguyen, T.T.,Milano, S.K.,Cerione, R.A. Filament formation drives catalysis by glutaminase enzymes important in cancer progression. Nat Commun, 15:1971-1971, 2024 Cited by PubMed: 38438397DOI: 10.1038/s41467-024-46351-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.35 Å) |
Structure validation
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